VPS52

Homolog vakuolskog sortiranjem pridruženog proteina 52 jest protein koji je kod ljudi kodiran genom VPS5VEGF2.

VPS52
Identifikatori
Aliasi	VPS52
Vanjski ID-jevi	OMIM: 603443 MGI: 1330304 HomoloGene: 5756 GeneCards: VPS52
Lokacija gena (čovjek) Hrom. Hromosom 6 (čovjek) Bend 6p21.32 Početak 33,250,272 bp Kraj 33,272,047 bp
Lokacija gena (miš) Hrom. Hromosom 17 (miš) Bend 17|17 B1 Početak 34,174,786 bp Kraj 34,186,009 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • syntaxin binding • GO:0001948, GO:0016582 vezivanje za proteine Ćelijska komponenta • perinuklearno područje citoplazme • reciklirajući endosom • EARP complex • endozom • Golđijev aparat • endosome membrane • membrana • trans-Golgi network membrane • GARP complex • citosol Biološki proces • protein transport • ectodermal cell differentiation • embryonic ectodermal digestive tract development • endocytic recycling • lysosomal transport • Golgi to vacuole transport • retrograde transport, endosome to Golgi Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	6293	224705
Ensembl	ENSG00000236014 ENSG00000206286 ENSG00000223501 ENSG00000224455 ENSG00000225590 ENSG00000223618 ENSG00000228425	ENSMUSG00000024319
UniProt	Q8N1B4	Q8C754
RefSeq (mRNK)	NM_001289174 NM_001289175 NM_001289176 NM_022553	NM_172620 NM_001357329 NM_001357330 NM_001379410 NM_001379411
RefSeq (bjelančevina)	NP_001276103 NP_001276104 NP_001276105 NP_072047	NP_766208 NP_001344258 NP_001344259 NP_001366339 NP_001366340
Lokacija (UCSC)	Chr 6: 33.25 – 33.27 Mb	Chr 17: 34.17 – 34.19 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 723 aminokiseline, а molekulska težina 82.221 Da.

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MAAAATMAAA		ARELVLRAGT		SDMEEEEGPL		AGGPGLQEPL		QLGELDITSD
EFILDEVDVH		IQANLEDELV		KEALKTGVDL		RHYSKQVELE		LQQIEQKSIR
DYIQESENIA		SLHNQITACD		AVLERMEQML		GAFQSDLSSI		SSEIRTLQEQ
SGAMNIRLRN		RQAVRGKLGE		LVDGLVVPSA		LVTAILEAPV		TEPRFLEQLQ
ELDAKAAAVR		EQEARGTAAC		ADVRGVLDRL		RVKAVTKIRE		FILQKIYSFR
KPMTNYQIPQ		TALLKYRFFY		QFLLGNERAT		AKEIRDEYVE		TLSKIYLSYY
RSYLGRLMKV		QYEEVAEKDD		LMGVEDTAKK		GFFSKPSLRS		RNTIFTLGTR
GSVISPTELE		APILVPHTAQ		RGEQRYPFEA		LFRSQHYALL		DNSCREYLFI
CEFFVVSGPA		AHDLFHAVMG		RTLSMTLKHL		DSYLADCYDA		IAVFLCIHIV
LRFRNIAAKR		DVPALDRYWE		QVLALLWPRF		ELILEMNVQS		VRSTDPQRLG
GLDTRPHYIT		RRYAEFSSAL		VSINQTIPNE		RTMQLLGQLQ		VEVENFVLRV
AAEFSSRKEQ		LVFLINNYDM		MLGVLMERAA		DDSKEVESFQ		QLLNARTQEF
IEELLSPPFG		GLVAFVKEAE		ALIERGQAER		LRGEEARVTQ		LIRGFGSSWK
SSVESLSQDV		MRSFTNFRNG		TSIIQGALTQ		LIQLYHRFHR		VLSQPQLRAL
PARAELINIH		HLMVELKKHK		PNF

Funkcija

Ovaj gen kodira protein sličan supresoru kvaščevog gena za aktinske mutacije 2. Kvašćev protein čini podjedinicu tetramernog Golgijevog asocijativnog retrogradnog proteinskog kompleksa koji je uključen u peromet vezikula) iz ranog i kasnog endosoma, natrag na trans-Golgijevu mrežu. Ovaj gen se nalazi na hromosomu 6 u orijentaciji licem u glavu sa genom koji kodira ribosomni protein S18.

Dopunska literatura

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Stephens R, Horton R, Humphray S, et al. (1999). "Gene organisation, sequence variation and isochore structure at the centromeric boundary of the human MHC". J. Mol. Biol. 291 (4): 789–99. doi:10.1006/jmbi.1999.3004. PMID 10452889.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Liewen H, Meinhold-Heerlein I, Oliveira V, et al. (2005). "Characterization of the human GARP (Golgi associated retrograde protein) complex". Exp. Cell Res. 306 (1): 24–34. doi:10.1016/j.yexcr.2005.01.022. PMID 15878329.