VPS45

Vakuolski protein 45 pridružen sortiranju jest protein koji je kod ljudi kodiran genom VPS45 sa hromosoma 1.

VPS45
Identifikatori
Aliasi	VPS45
Vanjski ID-jevi	OMIM: 610035 MGI: 891965 HomoloGene: 5250 GeneCards: VPS45
Lokacija gena (čovjek) Hrom. Hromosom 1 (čovjek) Bend 1q21.2 Početak 150,067,279 bp Kraj 150,145,329 bp
Lokacija gena (miš) Hrom. Hromosom 3 (miš) Bend 3 F2.1|3 41.65 cM Početak 95,907,144 bp Kraj 95,965,778 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • GO:0001948, GO:0016582 vezivanje za proteine • molekularna funkcija Ćelijska komponenta • integral component of membrane • endozom • Golđijev aparat • endosome membrane • membrana • Golđijeva membrana • ćelijska komponenta • Sinapsna vezikula Biološki proces • protein transport • intracellular protein transport • Koagulacija (krv) • vesicle-mediated transport • vesicle docking involved in exocytosis Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	11311	22365
Ensembl	ENSG00000136631	ENSMUSG00000015747
UniProt	Q9NRW7	P97390
RefSeq (mRNK)	NM_001279353 NM_001279354 NM_001279355 NM_007259	NM_013841
RefSeq (bjelančevina)	NP_001266282 NP_001266283 NP_009190	NP_038869
Lokacija (UCSC)	Chr 1: 150.07 – 150.15 Mb	Chr 3: 95.91 – 95.97 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 570 aminokiselina, a molekulska težina 65.077 Da.

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MNVVFAVKQY		ISKMIEDSGP		GMKVLLMDKE		TTGIVSMVYT		QSEILQKEVY
LFERIDSQNR		EIMKHLKAIC		FLRPTKENVD		YIIQELRRPK		YTIYFIYFSN
VISKSDVKSL		AEADEQEVVA		EVQEFYGDYI		AVNPHLFSLN		ILGCCQGRNW
DPAQLSRTTQ		GLTALLLSLK		KCPMIRYQLS		SEAAKRLAEC		VKQVITKEYE
LFEFRRTEVP		PLLLILDRCD		DAITPLLNQW		TYQAMVHELL		GINNNRIDLS
RVPGISKDLR		EVVLSAENDE		FYANNMYLNF		AEIGSNIKNL		MEDFQKKKPK
EQQKLESIAD		MKAFVENYPQ		FKKMSGTVSK		HVTVVGELSR		LVSERNLLEV
SEVEQELACQ		NDHSSALQNI		KRLLQNPKVT		EFDAARLVML		YALHYERHSS
NSLPGLMMDL		RNKGVSEKYR		KLVSAVVEYG		GKRVRGSDLF		SPKDAVAITK
QFLKGLKGVE		NVYTQHQPFL		HETLDHLIKG		RLKENLYPYL		GPSTLRDRPQ
DIIVFVIGGA		TYEEALTVYN		LNRTTPGVRI		VLGGTTVHNT		KSFLEEVLAS
GLHSRSKESS		QVTSRSASRR

Funkcija

Vezikulski posredovano sortiranje proteina ima važnu ulogu u segregaciji unutarćelijskihih molekula u različite organela. Genetičke studije kvasca identifikovale su više od 40 vakuokskih sortiranja proteina (VPS) gena uključenih u transport vezikula do vakuola. Ovaj gen je član porodice Sec1 domena i pokazuje visok stepen sličnosti sekvence sa mišjim, pacovskim i kvaščevim Vps45. Tačna funkcija ovog gena nije poznata, ali njegova visoka ekspresija u monjedarnim ćelijamama periferne krvi ukazuje na ulogu u prometu proteina, uključujući upalnene medijatore.

Dopunska literatura

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