VGLL3
Član 3 porodice rudimentolikih proteina jest protein koji je kod ljudi kodiran genom VGLL3 sa hromosoma 3.[5]
Aminokiselinska sekvenca uredi
Dužina polipeptidnog lanca je 326 aminokiselina, а molekulska težina 36.009 Da.[6]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MSCAEVMYHP | QPYGASQYLP | NPMAATTCPT | AYYQPAPQPG | QQKKLAVFSK | ||||
| MQDSLEVTLP | SKQEEEDEEE | EEEEKDQPAE | MEYLNSRCVL | FTYFQGDIGS | ||||
| VVDEHFSRAL | GQAITLHPES | AISKSKMGLT | PLWRDSSALS | SQRNSFPTSF | ||||
| WTSSYQPPPA | PCLGGVHPDF | QVTGPPGTFS | AADPSPWPGH | NLHQTGPAPP | ||||
| PAVSESWPYP | LTSQVSPSYS | HMHDVYMRHH | HPHAHMHHRH | RHHHHHHHPP | ||||
| AGSALDPSYG | PLLMPSVHAA | RIPAPQCDIT | KTEPTTVTSA | TSAWAGAFHG | ||||
| TVDIVPSVGF | DTGLQHQDKS | KESPWY |
Reference uredi
- ^ a b c GRCh38: Ensembl release 89: ENSG00000206538 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000091243 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Vestigial-like family member 3".
- ^ "UniProt, A8MV65" (jezik: engleski). Pristupljeno 6. 11. 2021.
Dopunska literatura uredi
- Tao S, Wang Z, Feng J, Hsu FC, Jin G, Kim ST, Zhang Z, Gronberg H, Zheng LS, Isaacs WB, Xu J, Sun J (mart 2012). "A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants". Carcinogenesis. 33 (3): 598–603. doi:10.1093/carcin/bgr316. PMC 3291863. PMID 22219177.
- Gambaro K, Quinn MC, Wojnarowicz PM, Arcand SL, de Ladurantaye M, Barrès V, Ripeau JS, Killary AM, Davis EC, Lavoie J, Provencher DM, Mes-Masson AM, Chevrette M, Tonin PN (juni 2013). "VGLL3 expression is associated with a tumor suppressor phenotype in epithelial ovarian cancer". Molecular Oncology. 7 (3): 513–30. doi:10.1016/j.molonc.2012.12.006. PMC 5528482. PMID 23415753.
- Zhou W, Chen H, Zhang L (mart 2009). "The PcG protein hPc2 interacts with the N-terminus of histone demethylase JARID1B and acts as a transcriptional co-repressor". BMB Reports. 42 (3): 154–9. doi:10.5483/bmbrep.2009.42.3.154. PMID 19336002.
- Halperin DS, Pan C, Lusis AJ, Tontonoz P (februar 2013). "Vestigial-like 3 is an inhibitor of adipocyte differentiation". Journal of Lipid Research. 54 (2): 473–81. doi:10.1194/jlr.M032755. PMC 3541706. PMID 23152581.
- Hélias-Rodzewicz Z, Pérot G, Chibon F, Ferreira C, Lagarde P, Terrier P, Coindre JM, Aurias A (decembar 2010). "YAP1 and VGLL3, encoding two cofactors of TEAD transcription factors, are amplified and overexpressed in a subset of soft tissue sarcomas". Genes, Chromosomes & Cancer. 49 (12): 1161–71. doi:10.1002/gcc.20825. PMID 20842732. S2CID 205828045.
- Wang L, Lu W, Chen YG, Zhou XM, Gu JR (decembar 1999). "Comparison of gene expression between normal colon mucosa and colon carcinoma by means of messenger RNA differential display". World Journal of Gastroenterology. 5 (6): 533–534. doi:10.3748/wjg.v5.i6.533. PMC 4688801. PMID 11819507.
- Maeda T, Chapman DL, Stewart AF (decembar 2002). "Mammalian vestigial-like 2, a cofactor of TEF-1 and MEF2 transcription factors that promotes skeletal muscle differentiation". The Journal of Biological Chemistry. 277 (50): 48889–98. doi:10.1074/jbc.M206858200. PMID 12376544.