UXS1
UDP-glukuronskokiselinska dekarbokslaza 1 jest enzim koji je kod ljudi kodiran genom UXS1 sa hromosoma 2.[5][6]
Amiokiselininska sekvenca
urediDužina polipeptidnog lanca je 420 aminokiselina, a molekulska težina 47.577 Da.[7]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MVSKALLRLV | SAVNRRRMKL | LLGIALLAYV | ASVWGNFVNM | RSIQENGELK | ||||
| IESKIEEMVE | PLREKIRDLE | KSFTQKYPPV | KFLSEKDRKR | ILITGGAGFV | ||||
| GSHLTDKLMM | DGHEVTVVDN | FFTGRKRNVE | HWIGHENFEL | INHDVVEPLY | ||||
| IEVDQIYHLA | SPASPPNYMY | NPIKTLKTNT | IGTLNMLGLA | KRVGARLLLA | ||||
| STSEVYGDPE | VHPQSEDYWG | HVNPIGPRAC | YDEGKRVAET | MCYAYMKQEG | ||||
| VEVRVARIFN | TFGPRMHMND | GRVVSNFILQ | ALQGEPLTVY | GSGSQTRAFQ | ||||
| YVSDLVNGLV | ALMNSNVSSP | VNLGNPEEHT | ILEFAQLIKN | LVGSGSEIQF | ||||
| LSEAQDDPQK | RKPDIKKAKL | MLGWEPVVPL | EEGLNKAIHY | FRKELEYQAN | ||||
| NQYIPKPKPA | RIKKGRTRHS |
Funkcija
urediUDP-glukuronat dekarboksilaza (UGD; EC 4.1.1.35) katalizira stvaranje UDP-ksiloze iz UDP-glukuronata. UDP-ksiloza se zatim koristi za iniciranje biosinteze glikozaminoglikana na jezgri proteinskih proteoglikanaa (prema OMIM-u)[6]
Također pogledajte
urediReference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000115652 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000057363 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (Short-Chain Dehydrogenase/Reductase and Related Enzymes) Nomenclature Initiative". Chem Biol Interact. 178 (1–3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
- ^ a b "Entrez Gene: UXS1 UDP-glucuronate decarboxylase 1".
- ^ "UniProt, Q8NBZ7" (jezik: engleski). Pristupljeno 18. 11. 2021.
Dopunska literatura
uredi- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Moriarity JL, Hurt KJ, Resnick AC, et al. (2002). "UDP-glucuronate decarboxylase, a key enzyme in proteoglycan synthesis: cloning, characterization, and localization". J. Biol. Chem. 277 (19): 16968–75. doi:10.1074/jbc.M109316200. PMID 11877387.
- Hwang HY, Horvitz HR (2002). "The SQV-1 UDP-glucuronic acid decarboxylase and the SQV-7 nucleotide-sugar transporter may act in the Golgi apparatus to affect Caenorhabditis elegans vulval morphogenesis and embryonic development". Proc. Natl. Acad. Sci. U.S.A. 99 (22): 14218–23. Bibcode:2002PNAS...9914218H. doi:10.1073/pnas.172522199. PMC 137864. PMID 12391314.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
- Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.