Ubikvitinska karboksil-terminalna hidrolaza 47 je enzim koji je kod ljudi kodiran genom USP47.[5][6]

USP47
Identifikatori
AliasiUSP47
Vanjski ID-jeviOMIM: 614460 MGI: 1922246 HomoloGene: 9929 GeneCards: USP47
Lokacija gena (čovjek)
Hromosom 11 (čovjek)
Hrom.Hromosom 11 (čovjek)[1]
Hromosom 11 (čovjek)
Genomska lokacija za USP47
Genomska lokacija za USP47
Bend11p15.3Početak11,841,423 bp[1]
Kraj11,959,323 bp[1]
Lokacija gena (miš)
Hromosom 7 (miš)
Hrom.Hromosom 7 (miš)[2]
Hromosom 7 (miš)
Genomska lokacija za USP47
Genomska lokacija za USP47
Bend7|7 F1Početak111,622,711 bp[2]
Kraj111,710,868 bp[2]
Obrazac RNK ekspresije
Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija WD40-repeat domain binding
GO:0070122 peptidase activity
hydrolase activity
cysteine-type peptidase activity
thiol-dependent deubiquitinase
GO:0001948, GO:0016582 protein binding
GO:1904265 deubiquitinase activity
cysteine-type endopeptidase activity
Ćelijska komponenta citoplazma
SCF ubiquitin ligase complex
Nukleoplazma
citosol
Biološki proces ubiquitin-dependent protein catabolic process
Proteoliza
negative regulation of apoptotic process
cellular response to UV
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:0100026 Popravka DNK
positive regulation of cell growth
monoubiquitinated protein deubiquitination
base-excision repair
negative regulation of G2/M transition of mitotic cell cycle
GO:0045996 negative regulation of transcription, DNA-templated
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
cellular response to DNA damage stimulus
protein deubiquitination
positive regulation of canonical Wnt signaling pathway
regulation of protein stability
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_001282659
NM_017944
NM_001330208

NM_133758
NM_177249
NM_001357952

RefSeq (bjelančevina)
NP_001269588
NP_001317137
NP_060414
NP_001359020
NP_001359021

NP_001359022
NP_001359023
NP_001359024
NP_001359025
NP_001359026
NP_001359027
NP_001359028
NP_001359029
NP_001359030
NP_001359031
NP_001359032

NP_598519
NP_796223
NP_001344881
NP_001390423

Lokacija (UCSC)Chr 11: 11.84 – 11.96 MbChr 7: 111.62 – 111.71 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca uredi

Dužina polipeptidnog lanca je 1.375 aminokiselina, а molekulska težina 157.311 Da.[7]

1020304050
MVPGEENQLVPKEDVFWRCRQNIFDEMKKKFLQIENAAEEPRVLCIIQDT
TNSKTVNERITLNLPASTPVRKLFEDVANKVGYINGTFDLVWGNGINTAD
MAPLDHTSDKSLLDANFEPGKKNFLHLTDKDGEQPQILLEDSSAGEDSVH
DRFIGPLPREGSGGSTSDYVSQSYSYSSILNKSETGYVGLVNQAMTCYLN
SLLQTLFMTPEFRNALYKWEFEESEEDPVTSIPYQLQRLFVLLQTSKKRA
IETTDVTRSFGWDSSEAWQQHDVQELCRVMFDALEQKWKQTEQADLINEL
YQGKLKDYVRCLECGYEGWRIDTYLDIPLVIRPYGSSQAFASVEEALHAF
IQPEILDGPNQYFCERCKKKCDARKGLRFLHFPYLLTLQLKRFDFDYTTM
HRIKLNDRMTFPEELDMSTFIDVEDEKSPQTESCTDSGAENEGSCHSDQM
SNDFSNDDGVDEGICLETNSGTEKISKSGLEKNSLIYELFSVMVHSGSAA
GGHYYACIKSFSDEQWYSFNDQHVSRITQEDIKKTHGGSSGSRGYYSSAF
ASSTNAYMLIYRLKDPARNAKFLEVDEYPEHIKNLVQKERELEEQEKRQR
EIERNTCKIKLFCLHPTKQVMMENKLEVHKDKTLKEAVEMAYKMMDLEEV
IPLDCCRLVKYDEFHDYLERSYEGEEDTPMGLLLGGVKSTYMFDLLLETR
KPDQVFQSYKPGEVMVKVHVVDLKAESVAAPITVRAYLNQTVTEFKQLIS
KAIHLPAETMRIVLERCYNDLRLLSVSSKTLKAEGFFRSNKVFVESSETL
DYQMAFADSHLWKLLDRHANTIRLFVLLPEQSPVSYSKRTAYQKAGGDSG
NVDDDCERVKGPVGSLKSVEAILEESTEKLKSLSLQQQQDGDNGDSSKST
ETSDFENIESPLNERDSSASVDNRELEQHIQTSDPENFQSEERSDSDVNN
DRSTSSVDSDILSSSHSSDTLCNADNAQIPLANGLDSHSITSSRRTKANE
GKKETWDTAEEDSGTDSEYDESGKSRGEMQYMYFKAEPYAADEGSGEGHK
WLMVHVDKRITLAAFKQHLEPFVGVLSSHFKVFRVYASNQEFESVRLNET
LSSFSDDNKITIRLGRALKKGEYRVKVYQLLVNEQEPCKFLLDAVFAKGM
TVRQSKEELIPQLREQCGLELSIDRFRLRKKTWKNPGTVFLDYHIYEEDI
NISSNWEVFLEVLDGVEKMKSMSQLAVLSRRWKPSEMKLDPFQEVVLESS
SVDELREKLSEISGIPLDDIEFAKGRGTFPCDISVLDIHQDLDWNPKVST
LNVWPLYICDDGAVIFYRDKTEELMELTDEQRNELMKKESSRLQKTGHRV
TYSPRKEKALKIYLDGAPNKDLTQD

Reference uredi

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000170242 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059263 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346. S2CID 2856065.
  6. ^ "Entrez Gene: USP47 ubiquitin specific peptidase 47".
  7. ^ "UniProt, Q96K76". Pristupljeno 29. 8. 2021.

Dopunska literatura uredi

Vanjski linkovi uredi