UDP-N-acetilheksozamin pirofosforilaza je enzim koji je kod ljudi kodiran genom UAP1 sa hromosoma 1.[5][6][7]

UAP1
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

1JV1, 1JV3, 1JVD, 1JVG

Identifikatori
AliasiUAP1
Vanjski ID-jeviOMIM: 602862 MGI: 1334459 HomoloGene: 2342 GeneCards: UAP1
Lokacija gena (čovjek)
Hromosom 1 (čovjek)
Hrom.Hromosom 1 (čovjek)[1]
Hromosom 1 (čovjek)
Genomska lokacija za UAP1
Genomska lokacija za UAP1
Bend1q23.3Početak162,561,722 bp[1]
Kraj162,601,240 bp[1]
Lokacija gena (miš)
Hromosom 1 (miš)
Hrom.Hromosom 1 (miš)[2]
Hromosom 1 (miš)
Genomska lokacija za UAP1
Genomska lokacija za UAP1
Bend1|1 H3Početak169,969,507 bp[2]
Kraj170,002,526 bp[2]
Obrazac RNK ekspresije
Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija aktivnost sa transferazom
uridylyltransferase activity
nucleotidyltransferase activity
carbohydrate binding
vezivanje identičnih proteina
UDP-N-acetylglucosamine diphosphorylase activity
Ćelijska komponenta ćelijska membrana
nukleoplazma
citoplazma
citosol
Biološki proces UDP-N-acetylglucosamine metabolic process
metabolizam
UDP-N-acetylglucosamine biosynthetic process
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)
NM_003115
NM_001324113
NM_001324114
NM_001324115
NM_001324116

NM_001324117
NM_001388401
NM_001388402
NM_001399790
NM_001399791
NM_001399792
NM_001399793

NM_133806
NM_001305045
NM_001305046

RefSeq (bjelančevina)
NP_001311042
NP_001311043
NP_001311044
NP_001311045
NP_001311046

NP_003106

NP_001291974
NP_001291975
NP_598567

Lokacija (UCSC)Chr 1: 162.56 – 162.6 MbChr 1: 169.97 – 170 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

uredi

Dužina polipeptidnog lanca je 522 aminokiseline, a molekulska težina 58.769 Da.[8]

1020304050
MNINDLKLTLSKAGQEHLLRFWNELEEAQQVELYAELQAMNFEELNFFFQ
KAIEGFNQSSHQKNVDARMEPVPREVLGSATRDQDQLQAWESEGLFQISQ
NKVAVLLLAGGQGTRLGVAYPKGMYDVGLPSRKTLFQIQAERILKLQQVA
EKYYGNKCIIPWYIMTSGRTMESTKEFFTKHKYFGLKKENVIFFQQGMLP
AMSFDGKIILEEKNKVSMAPDGNGGLYRALAAQNIVEDMEQRGIWSIHVY
CVDNILVKVADPRFIGFCIQKGADCGAKVVEKTNPTEPVGVVCRVDGVYQ
VVEYSEISLATAQKRSSDGRLLFNAGNIANHFFTVPFLRDVVNVYEPQLQ
HHVAQKKIPYVDTQGQLIKPDKPNGIKMEKFVFDIFQFAKKFVVYEVLRE
DEFSPLKNADSQNGKDNPTTARHALMSLHHCWVLNAGGHFIDENGSRLPA
IPRSATNGKSETITADVNHNLKDANDVPIQCEISPLISYAGEGLESYVAD
KEFHAPLIIDENGVHELVKNGI

Reference

uredi
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000117143 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026670 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Mio T, Yabe T, Arisawa M, Yamada-Okabe H (Jul 1998). "The eukaryotic UDP-N-acetylglucosamine pyrophosphorylases. Gene cloning, protein expression, and catalytic mechanism". J Biol Chem. 273 (23): 14392–7. doi:10.1074/jbc.273.23.14392. PMID 9603950.
  6. ^ Diekman AB, Goldberg E (Aug 1994). "Characterization of a human antigen with sera from infertile patients". Biol Reprod. 50 (5): 1087–93. doi:10.1095/biolreprod50.5.1087. PMID 8025165.
  7. ^ "Entrez Gene: UAP1 UDP-N-acteylglucosamine pyrophosphorylase 1".
  8. ^ "UniProt, Q16222" (jezik: en.). Pristupljeno 13. 12. 2021.CS1 održavanje: nepoznati jezik (link)

Dopunska literatura

uredi

Vanjski linkovi

uredi