UCN3

UCN3
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2RMH, 3N93
Identifikatori
Aliasi	UCN3
Vanjski ID-jevi	OMIM: 605901 MGI: 1932970 HomoloGene: 49959 GeneCards: UCN3
Lokacija gena (čovjek)
Hrom.	Hromosom 10 (čovjek)
Kraj	5,374,692 bp
Lokacija gena (miš)
Hrom.	Hromosom 13 (miš)
Kraj	3,995,349 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• G protein-coupled receptor binding; • corticotropin-releasing hormone receptor 2 binding; • hormone activity; • corticotropin-releasing hormone receptor binding;
Ćelijska komponenta	• neuron projection; • varicosity; • axon terminus; • Akson; • extracellular region; • Vanćelijsko; • intracellular anatomical structure;
Biološki proces	• varenje; • response to stress; • cellular response to nutrient levels; • positive regulation of insulin secretion; • response to immobilization stress; • response to glucose; • response to starvation; • cellular response to hypoxia; • positive regulation of membrane potential; • response to corticosterone; • regulation of signaling receptor activity; • adenylate cyclase-activating G protein-coupled receptor signaling pathway; • hormone-mediated signaling pathway;
	Izvori:Amigo / QuickGO
Ortolozi
	114131
	83428
	ENSG00000178473
	ENSMUSG00000044988
	Q969E3
	Q924A4
	NM_053049
	NM_031250
	NP_444277
	NP_112540
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Urokortin-3 je protein koji je kod ljudi kodiran genom UCN3.^[5]^[6] Pripada porodici kortikotropin-oslobađajućih hormona.^[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 161 aminokiselina, а molekulska težina 17.961 Da.^[8]

10	20	30	40	50
MLMPVHFLLL	LLLLLGGPRT	GLPHKFYKAK	PIFSCLNTAL	SEAEKGQWED
ASLLSKRSFH	YLRSRDASSG	EEEEGKEKKT	FPISGARGGA	RGTRYRYVSQ
AQPRGKPRQD	TAKSPHRTKF	TLSLDVPTNI	MNLLFNIAKA	KNLRAQAAAN
AHLMAQIGRK	K

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

Funkcija

Ovaj gen je član porodice sauvagin/kortikotropin-oslobađajući faktor/porodice urotenzina I. Strukturno je povezan s genom kortikotropin-oslobađajućeg faktora (CRF), a kodirani proizvod je endogeni ligand za receptore tipa 2 CRF.

U mozgu može biti odgovoran za efekte stresa na apetit). Izražava se i u beta-ćelijama u pankreasu i oslobađa se zajedno sa insulinom za podsticanje oslobađanja somatostatina iz susjednih delta-ćelija, što daje negativnu povratnu informaciju na lučenje insulina.^[9] Unatoć sličnosti imena gena, proizvod ovog gena nema sličnosti u sekvenci sa urotenzinom II.^[6]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000178473 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000044988 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lewis K, Li C, Perrin MH, Blount A, Kunitake K, Donaldson C, Vaughan J, Reyes TM, Gulyas J, Fischer W, Bilezikjian L, Rivier J, Sawchenko PE, Vale WW (Jun 2001). "Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor". Proceedings of the National Academy of Sciences of the United States of America. 98 (13): 7570–5. doi:10.1073/pnas.121165198. PMC 34709. PMID 11416224.
^ ^a ^b "Entrez Gene: UCN3 urocortin 3 (stresscopin)".
^ Zhang X, Liu Y, Qi J, Tian Z, Tang N, Chen D, Li Z (2019). "Progress in understanding the roles of Urocortin3 (UCN3) in the control of appetite from studies using animal models". Peptides. 121: 170124. doi:10.1016/j.peptides.2019.170124. PMID 31415798. S2CID 199544428.CS1 održavanje: upotreba parametra authors (link)
^ "UniProt, Q969E3". Pristupljeno 5. 9. 2021.
^ van der Meulen T, Donaldson CJ, Cáceres E, Hunter AE, Cowing-Zitron C, Pound LD, Adams MW, Zembrzycki A, Grove KL, Huising MO (Jul 2015). "Urocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion". Nature Medicine. 21 (7): 769–76. doi:10.1038/nm.3872. PMC 4496282. PMID 26076035.

Dopunska literatura

Hauger RL, Grigoriadis DE, Dallman MF, Plotsky PM, Vale WW, Dautzenberg FM (Mar 2003). "International Union of Pharmacology. XXXVI. Current status of the nomenclature for receptors for corticotropin-releasing factor and their ligands". Pharmacological Reviews. 55 (1): 21–6. doi:10.1124/pr.55.1.3. PMID 12615952. S2CID 1572317.
Florio P, Torres PB, Torricelli M, Toti P, Vale W, Petraglia F (Dec 2006). "Human endometrium expresses urocortin II and III messenger RNA and peptides". Fertility and Sterility. 86 (6): 1766–70. doi:10.1016/j.fertnstert.2006.05.041. PMID 17074339.
Imperatore A, Florio P, Torres PB, Torricelli M, Galleri L, Toti P, Occhini R, Picciolini E, Vale W, Petraglia F (Jul 2006). "Urocortin 2 and urocortin 3 are expressed by the human placenta, deciduas, and fetal membranes". American Journal of Obstetrics and Gynecology. 195 (1): 288–95. doi:10.1016/j.ajog.2005.12.048. PMID 16626608.
Saruta M, Takahashi K, Suzuki T, Fukuda T, Torii A, Sasano H (Jul 2005). "Urocortin 3/stresscopin in human colon: possible modulators of gastrointestinal function during stressful conditions". Peptides. 26 (7): 1196–206. doi:10.1016/j.peptides.2005.01.014. PMID 15949638. S2CID 23604531.
Chang CL, Hsu SY (Oct 2004). "Ancient evolution of stress-regulating peptides in vertebrates". Peptides. 25 (10): 1681–8. doi:10.1016/j.peptides.2004.05.022. PMID 15476935. S2CID 25716793.
Takahashi K, Totsune K, Murakami O, Saruta M, Nakabayashi M, Suzuki T, Sasano H, Shibahara S (Apr 2004). "Expression of urocortin III/stresscopin in human heart and kidney". The Journal of Clinical Endocrinology and Metabolism. 89 (4): 1897–903. doi:10.1210/jc.2003-031663. PMID 15070962.
Seres J, Bornstein SR, Seres P, Willenberg HS, Schulte KM, Scherbaum WA, Ehrhart-Bornstein M (Feb 2004). "Corticotropin-releasing hormone system in human adipose tissue". The Journal of Clinical Endocrinology and Metabolism. 89 (2): 965–70. doi:10.1210/jc.2003-031299. PMID 14764822.
Chanalaris A, Lawrence KM, Stephanou A, Knight RD, Hsu SY, Hsueh AJ, Latchman DS (Oct 2003). "Protective effects of the urocortin homologues stresscopin (SCP) and stresscopin-related peptide (SRP) against hypoxia/reoxygenation injury in rat neonatal cardiomyocytes". Journal of Molecular and Cellular Cardiology. 35 (10): 1295–305. doi:10.1016/S0022-2828(03)00244-X. PMID 14519439.
Hsu SY, Hsueh AJ (maj 2001). "Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor". Nature Medicine. 7 (5): 605–11. doi:10.1038/87936. PMID 11329063. S2CID 22916906.

Vanjski linkovi

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000178473 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000044988 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11416224-5] Lewis K, Li C, Perrin MH, Blount A, Kunitake K, Donaldson C, Vaughan J, Reyes TM, Gulyas J, Fischer W, Bilezikjian L, Rivier J, Sawchenko PE, Vale WW (Jun 2001). "Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor". Proceedings of the National Academy of Sciences of the United States of America. 98 (13): 7570–5. doi:10.1073/pnas.121165198. PMC 34709. PMID 11416224.

[entrez-6] "Entrez Gene: UCN3 urocortin 3 (stresscopin)".

[Urocortin3-7] Zhang X, Liu Y, Qi J, Tian Z, Tang N, Chen D, Li Z (2019). "Progress in understanding the roles of Urocortin3 (UCN3) in the control of appetite from studies using animal models". Peptides. 121: 170124. doi:10.1016/j.peptides.2019.170124. PMID 31415798. S2CID 199544428.CS1 održavanje: upotreba parametra authors (link)

[UniProt-8] "UniProt, Q969E3". Pristupljeno 5. 9. 2021.

[pmid26076035-9] van der Meulen T, Donaldson CJ, Cáceres E, Hunter AE, Cowing-Zitron C, Pound LD, Adams MW, Zembrzycki A, Grove KL, Huising MO (Jul 2015). "Urocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion". Nature Medicine. 21 (7): 769–76. doi:10.1038/nm.3872. PMC 4496282. PMID 26076035.

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