E3 ubikvitin-protein ligaza UBR4 jest enzim koji je kod ljudi kodiran genom UBR4 sa hromosoma 1.[5][6][7][8]

UBR4
Identifikatori
AliasiUBR4
Vanjski ID-jeviOMIM: 609890 MGI: 1916366 HomoloGene: 10804 GeneCards: UBR4
Lokacija gena (čovjek)
Hromosom 1 (čovjek)
Hrom.Hromosom 1 (čovjek)[1]
Hromosom 1 (čovjek)
Genomska lokacija za UBR4
Genomska lokacija za UBR4
Bend1p36.13Početak19,074,510 bp[1]
Kraj19,210,266 bp[1]
Lokacija gena (miš)
Hromosom 4 (miš)
Hrom.Hromosom 4 (miš)[2]
Hromosom 4 (miš)
Genomska lokacija za UBR4
Genomska lokacija za UBR4
Bend4|4 D3Početak139,079,920 bp[2]
Kraj139,216,899 bp[2]
Obrazac RNK ekspresije


Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija vezivanje iona cinka
GO:0001948, GO:0016582 vezivanje za proteine
vezivanje iona metala
calmodulin binding
GO:0050372 aktivnost sa transferazom ubikvitina
aktivnost sa transferazom
Ćelijska komponenta integral component of membrane
centrosom
citoskelet
membrana
jedro
nukleoplazma
citoplazma
citosol
ćelijska membrana
specific granule membrane
tertiary granule membrane
ficolin-1-rich granule membrane
Biološki proces GO:0022415 viral process
protein ubiquitination
neutrophil degranulation
ubiquitin-dependent protein catabolic process
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_020765

NM_001160319

RefSeq (bjelančevina)

NP_065816

NP_001153791

Lokacija (UCSC)Chr 1: 19.07 – 19.21 MbChr 4: 139.08 – 139.22 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

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Dužina polipeptidnog lanca je 5.183 aminokiselina, a molekulska težina 573.841 Da.[9]

1020304050
MATSGGEEAAAAAPAPGTPATGADTTPGWEVAVRPLLSASYSAFEMKELP
QLVASVIESESEILHHEKQYEPFYSSFVALSTHYITTVCSLIPRNQLQSV
AAACKVLIEFSLLRLENPDEACAVSQKHLILLIKGLCTGCSRLDRTEIIT
FTAMMKSAKLPQTVKTLSDVEDQKELASPVSPELRQKEVQMNFLNQLTSV
FNPRTVASQPISTQTLVEGENDEQSSTDQASAIKTKNVFIAQNVASLQEL
GGSEKLLRVCLNLPYFLRYINRFQDAVLANSFFIMPATVADATAVRNGFH
SLVIDVTMALDTLSLPVLEPLNPSRLQDVTVLSLSCLYAGVSVATCMAIL
HVGSAQQVRTGSTSSKEDDYESDAATIVQKCLEIYDMIGQAISSSRRAGG
EHYQNFQLLGAWCLLNSLFLILNLSPTALADKGKEKDPLAALRVRDILSR
TKEGVGSPKLGPGKGHQGFGVLSVILANHAIKLLTSLFQDLQVEALHKGW
ETDGPPAALSIMAQSTSIQRIQRLIDSVPLMNLLLTLLSTSYRKACVLQR
QRKGSMSSDASASTDSNTYYEDDFSSTEEDSSQDDDSEPILGQWFEETIS
PSKEKAAPPPPPPPPPLESSPRVKSPSKQAPGEKGNILASRKDPELFLGL
ASNILNFITSSMLNSRNNFIRNYLSVSLSEHHMATLASIIKEVDKDGLKG
SSDEEFAAALYHFNHSLVTSDLQSPNLQNTLLQQLGVAPFSEGPWPLYIH
PQSLSVLSRLLLIWQHKASAQGDPDVPECLKVWDRFLSTMKQNALQGVVP
SETEDLNVEHLQMLLLIFHNFTETGRRAILSLFVQIIQELSVNMDAQMRF
VPLILARLLLIFDYLLHQYSKAPVYLFEQVQHNLLSPPFGWASGSQDSNS
RRATTPLYHGFKEVEENWSKHFSSDAVPHPRFYCVLSPEASEDDLNRLDS
VACDVLFSKLVKYDELYAALTALLAAGSQLDTVRRKENKNVTALEACALQ
YYFLILWRILGILPPSKTYINQLSMNSPEMSECDILHTLRWSSRLRISSY
VNWIKDHLIKQGMKAEHASSLLELASTTKCSSVKYDVEIVEEYFARQISS
FCSIDCTTILQLHEIPSLQSIYTLDAAISKVQVSLDEHFSKMAAETDPHK
SSEITKNLLPATLQLIDTYASFTRAYLLQNFNEEGTTEKPSKEKLQGFAA
VLAIGSSRCKANTLGPTLVQNLPSSVQTVCESWNNINTNEFPNIGSWRNA
FANDTIPSESYISAVQAAHLGTLCSQSLPLAASLKHTLLSLVRLTGDLIV
WSDEMNPPQVIRTLLPLLLESSTESVAEISSNSLERILGPAESDEFLARV
YEKLITGCYNILANHADPNSGLDESILEECLQYLEKQLESSQARKAMEEF
FSDSGELVQIMMATANENLSAKFCNRVLKFFTKLFQLTEKSPNPSLLHLC
GSLAQLACVEPVRLQAWLTRMTTSPPKDSDQLDVIQENRQLLQLLTTYIV
RENSQVGEGVCAVLLGTLTPMATEMLANGDGTGFPELMVVMATLASAGQG
AGHLQLHNAAVDWLSRCKKYLSQKNVVEKLNANVMHGKHVMILECTCHIM
SYLADVTNALSQSNGQGPSHLSVDGEERAIEVDSDWVEELAVEEEDSQAE
DSDEDSLCNKLCTFTITQKEFMNQHWYHCHTCKMVDGVGVCTVCAKVCHK
DHEISYAKYGSFFCDCGAKEDGSCLALVKRTPSSGMSSTMKESAFQSEPR
ISESLVRHASTSSPADKAKVTISDGKVADEEKPKKSSLCRTVEGCREELQ
NQANFSFAPLVLDMLNFLMDAIQTNFQQASAVGSSSRAQQALSELHTVEK
AVEMTDQLMVPTLGSQEGAFENVRMNYSGDQGQTIRQLISAHVLRRVAMC
VLSSPHGRRQHLAVSHEKGKITVLQLSALLKQADSSKRKLTLTRLASAPV
PFTVLSLTGNPCKEDYLAVCGLKDCHVLTFSSSGSVSDHLVLHPQLATGN
FIIKAVWLPGSQTELAIVTADFVKIYDLCVDALSPTFYFLLPSSKIRDVT
FLFNEEGKNIIVIMSSAGYIYTQLMEEASSAQQGPFYVTNVLEINHEDLK
DSNSQVAGGGVSVYYSHVLQMLFFSYCQGKSFAATISRTTLEVLQLFPIN
IKSSNGGSKTSPALCQWSEVMNHPGLVCCVQQTTGVPLVVMVKPDTFLIQ
EIKTLPAKAKIQDMVAIRHTACNEQQRTTMILLCEDGSLRIYMANVENTS
YWLQPSLQPSSVISIMKPVRKRKTATITTRTSSQVTFPIDFFEHNQQLTD
VEFGGNDLLQVYNAQQIKHRLNSTGMYVANTKPGGFTIEISNNNSTMVMT
GMRIQIGTQAIERAPSYIEIFGRTMQLNLSRSRWFDFPFTREEALQADKK
LNLFIGASVDPAGVTMIDAVKIYGKTKEQFGWPDEPPEEFPSASVSNICP
SNLNQSNGTGDSDSAAPTTTSGTVLERLVVSSLEALESCFAVGPIIEKER
NKNAAQELATLLLSLPAPASVQQQSKSLLASLHTSRSAYHSHKDQALLSK
AVQCLNTSSKEGKDLDPEVFQRLVITARSIAIMRPNNLVHFTESKLPQME
TEGMDEGKEPQKQLEGDCCSFITQLVNHFWKLHASKPKNAFLAPACLPGL
THIEATVNALVDIIHGYCTCELDCINTASKIYMQMLLCPDPAVSFSCKQA
LIRVLRPRNKRRHVTLPSSPRSNTPMGDKDDDDDDDADEKMQSSGIPNGG
HIRQESQEQSEVDHGDFEMVSESMVLETAENVNNGNPSPLEALLAGAEGF
PPMLDIPPDADDETMVELAIALSLQQDQQGSSSSALGLQSLGLSGQAPSS
SSLDAGTLSDTTASAPASDDEGSTAATDGSTLRTSPADHGGSVGSESGGS
AVDSVAGEHSVSGRSSAYGDATAEGHPAGPGSVSSSTGAISTTTGHQEGD
GSEGEGEGETEGDVHTSNRLHMVRLMLLERLLQTLPQLRNVGGVRAIPYM
QVILMLTTDLDGEDEKDKGALDNLLSQLIAELGMDKKDVSKKNERSALNE
VHLVVMRLLSVFMSRTKSGSKSSICESSSLISSATAAALLSSGAVDYCLH
VLKSLLEYWKSQQNDEEPVATSQLLKPHTTSSPPDMSPFFLRQYVKGHAA
DVFEAYTQLLTEMVLRLPYQIKKITDTNSRIPPPVFDHSWFYFLSEYLMI
QQTPFVRRQVRKLLLFICGSKEKYRQLRDLHTLDSHVRGIKKLLEEQGIF
LRASVVTASSGSALQYDTLISLMEHLKACAEIAAQRTINWQKFCIKDDSV
LYFLLQVSFLVDEGVSPVLLQLLSCALCGSKVLAALAASSGSSSASSSSA
PVAASSGQATTQSKSSTKKSKKEEKEKEKDGETSGSQEDQLCTALVNQLN
KFADKETLIQFLRCFLLESNSSSVRWQAHCLTLHIYRNSSKSQQELLLDL
MWSIWPELPAYGRKAAQFVDLLGYFSLKTPQTEKKLKEYSQKAVEILRTQ
NHILTNHPNSNIYNTLSGLVEFDGYYLESDPCLVCNNPEVPFCYIKLSSI
KVDTRYTTTQQVVKLIGSHTISKVTVKIGDLKRTKMVRTINLYYNNRTVQ
AIVELKNKPARWHKAKKVQLTPGQTEVKIDLPLPIVASNLMIEFADFYEN
YQASTETLQCPRCSASVPANPGVCGNCGENVYQCHKCRSINYDEKDPFLC
NACGFCKYARFDFMLYAKPCCAVDPIENEEDRKKAVSNINTLLDKADRVY
HQLMGHRPQLENLLCKVNEAAPEKPQDDSGTAGGISSTSASVNRYILQLA
QEYCGDCKNSFDELSKIIQKVFASRKELLEYDLQQREAATKSSRTSVQPT
FTASQYRALSVLGCGHTSSTKCYGCASAVTEHCITLLRALATNPALRHIL
VSQGLIRELFDYNLRRGAAAMREEVRQLMCLLTRDNPEATQQMNDLIIGK
VSTALKGHWANPDLASSLQYEMLLLTDSISKEDSCWELRLRCALSLFLMA
VNIKTPVVVENITLMCLRILQKLIKPPAPTSKKNKDVPVEALTTVKPYCN
EIHAQAQLWLKRDPKASYDAWKKCLPIRGIDGNGKAPSKSELRHLYLTEK
YVWRWKQFLSRRGKRTSPLDLKLGHNNWLRQVLFTPATQAARQAACTIVE
ALATIPSRKQQVLDLLTSYLDELSIAGECAAEYLALYQKLITSAHWKVYL
AARGVLPYVGNLITKEIARLLALEEATLSTDLQQGYALKSLTGLLSSFVE
VESIKRHFKSRLVGTVLNGYLCLRKLVVQRTKLIDETQDMLLEMLEDMTT
GTESETKAFMAVCIETAKRYNLDDYRTPVFIFERLCSIIYPEENEVTEFF
VTLEKDPQQEDFLQGRMPGNPYSSNEPGIGPLMRDIKNKICQDCDLVALL
EDDSGMELLVNNKIISLDLPVAEVYKKVWCTTNEGEPMRIVYRMRGLLGD
ATEEFIESLDSTTDEEEDEEEVYKMAGVMAQCGGLECMLNRLAGIRDFKQ
GRHLLTVLLKLFSYCVKVKVNRQQLVKLEMNTLNVMLGTLNLALVAEQES
KDSGGAAVAEQVLSIMEIILDESNAEPLSEDKGNLLLTGDKDQLVMLLDQ
INSTFVRSNPSVLQGLLRIIPYLSFGEVEKMQILVERFKPYCNFDKYDED
HSGDDKVFLDCFCKIAAGIKNNSNGHQLKDLILQKGITQNALDYMKKHIP
SAKNLDADIWKKFLSRPALPFILRLLRGLAIQHPGTQVLIGTDSIPNLHK
LEQVSSDEGIGTLAENLLEALREHPDVNKKIDAARRETRAEKKRMAMAMR
QKALGTLGMTTNEKGQVVTKTALLKQMEELIEEPGLTCCICREGYKFQPT
KVLGIYTFTKRVALEEMENKPRKQQGYSTVSHFNIVHYDCHLAAVRLARG
REEWESAALQNANTKCNGLLPVWGPHVPESAFATCLARHNTYLQECTGQR
EPTYQLNIHDIKLLFLRFAMEQSFSADTGGGGRESNIHLIPYIIHTVLYV
LNTTRATSREEKNLQGFLEQPKEKWVESAFEVDGPYYFTVLALHILPPEQ
WRATRVEILRRLLVTSQARAVAPGGATRLTDKAVKDYSAYRSSLLFWALV
DLIYNMFKKVPTSNTEGGWSCSLAEYIRHNDMPIYEAADKALKTFQEEFM
PVETFSEFLDVAGLLSEITDPESFLKDLLNSVP

Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000127481 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000066036 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
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  6. ^ Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O (Apr 2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
  7. ^ Tasaki T, Mulder LC, Iwamatsu A, Lee MJ, Davydov IV, Varshavsky A, Muesing M, Kwon YT (Aug 2005). "A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons". Mol Cell Biol. 25 (16): 7120–7136. doi:10.1128/MCB.25.16.7120-7136.2005. PMC 1190250. PMID 16055722.
  8. ^ "Entrez Gene: ZUBR1 zinc finger, UBR1 type 1".
  9. ^ "UniProt, Q5T4S7" (jezik: eng.). Pristupljeno 1. 12. 2021.CS1 održavanje: nepoznati jezik (link)

Dopunska literatura

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Vanjski linkovi

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