UBR4
E3 ubikvitin-protein ligaza UBR4 jest enzim koji je kod ljudi kodiran genom UBR4 sa hromosoma 1.[5][6][7][8]
Aminokiselinska sekvenca
urediDužina polipeptidnog lanca je 5.183 aminokiselina, a molekulska težina 573.841 Da.[9]
10 | 20 | 30 | 40 | 50 | ||||
---|---|---|---|---|---|---|---|---|
MATSGGEEAA | AAAPAPGTPA | TGADTTPGWE | VAVRPLLSAS | YSAFEMKELP | ||||
QLVASVIESE | SEILHHEKQY | EPFYSSFVAL | STHYITTVCS | LIPRNQLQSV | ||||
AAACKVLIEF | SLLRLENPDE | ACAVSQKHLI | LLIKGLCTGC | SRLDRTEIIT | ||||
FTAMMKSAKL | PQTVKTLSDV | EDQKELASPV | SPELRQKEVQ | MNFLNQLTSV | ||||
FNPRTVASQP | ISTQTLVEGE | NDEQSSTDQA | SAIKTKNVFI | AQNVASLQEL | ||||
GGSEKLLRVC | LNLPYFLRYI | NRFQDAVLAN | SFFIMPATVA | DATAVRNGFH | ||||
SLVIDVTMAL | DTLSLPVLEP | LNPSRLQDVT | VLSLSCLYAG | VSVATCMAIL | ||||
HVGSAQQVRT | GSTSSKEDDY | ESDAATIVQK | CLEIYDMIGQ | AISSSRRAGG | ||||
EHYQNFQLLG | AWCLLNSLFL | ILNLSPTALA | DKGKEKDPLA | ALRVRDILSR | ||||
TKEGVGSPKL | GPGKGHQGFG | VLSVILANHA | IKLLTSLFQD | LQVEALHKGW | ||||
ETDGPPAALS | IMAQSTSIQR | IQRLIDSVPL | MNLLLTLLST | SYRKACVLQR | ||||
QRKGSMSSDA | SASTDSNTYY | EDDFSSTEED | SSQDDDSEPI | LGQWFEETIS | ||||
PSKEKAAPPP | PPPPPPLESS | PRVKSPSKQA | PGEKGNILAS | RKDPELFLGL | ||||
ASNILNFITS | SMLNSRNNFI | RNYLSVSLSE | HHMATLASII | KEVDKDGLKG | ||||
SSDEEFAAAL | YHFNHSLVTS | DLQSPNLQNT | LLQQLGVAPF | SEGPWPLYIH | ||||
PQSLSVLSRL | LLIWQHKASA | QGDPDVPECL | KVWDRFLSTM | KQNALQGVVP | ||||
SETEDLNVEH | LQMLLLIFHN | FTETGRRAIL | SLFVQIIQEL | SVNMDAQMRF | ||||
VPLILARLLL | IFDYLLHQYS | KAPVYLFEQV | QHNLLSPPFG | WASGSQDSNS | ||||
RRATTPLYHG | FKEVEENWSK | HFSSDAVPHP | RFYCVLSPEA | SEDDLNRLDS | ||||
VACDVLFSKL | VKYDELYAAL | TALLAAGSQL | DTVRRKENKN | VTALEACALQ | ||||
YYFLILWRIL | GILPPSKTYI | NQLSMNSPEM | SECDILHTLR | WSSRLRISSY | ||||
VNWIKDHLIK | QGMKAEHASS | LLELASTTKC | SSVKYDVEIV | EEYFARQISS | ||||
FCSIDCTTIL | QLHEIPSLQS | IYTLDAAISK | VQVSLDEHFS | KMAAETDPHK | ||||
SSEITKNLLP | ATLQLIDTYA | SFTRAYLLQN | FNEEGTTEKP | SKEKLQGFAA | ||||
VLAIGSSRCK | ANTLGPTLVQ | NLPSSVQTVC | ESWNNINTNE | FPNIGSWRNA | ||||
FANDTIPSES | YISAVQAAHL | GTLCSQSLPL | AASLKHTLLS | LVRLTGDLIV | ||||
WSDEMNPPQV | IRTLLPLLLE | SSTESVAEIS | SNSLERILGP | AESDEFLARV | ||||
YEKLITGCYN | ILANHADPNS | GLDESILEEC | LQYLEKQLES | SQARKAMEEF | ||||
FSDSGELVQI | MMATANENLS | AKFCNRVLKF | FTKLFQLTEK | SPNPSLLHLC | ||||
GSLAQLACVE | PVRLQAWLTR | MTTSPPKDSD | QLDVIQENRQ | LLQLLTTYIV | ||||
RENSQVGEGV | CAVLLGTLTP | MATEMLANGD | GTGFPELMVV | MATLASAGQG | ||||
AGHLQLHNAA | VDWLSRCKKY | LSQKNVVEKL | NANVMHGKHV | MILECTCHIM | ||||
SYLADVTNAL | SQSNGQGPSH | LSVDGEERAI | EVDSDWVEEL | AVEEEDSQAE | ||||
DSDEDSLCNK | LCTFTITQKE | FMNQHWYHCH | TCKMVDGVGV | CTVCAKVCHK | ||||
DHEISYAKYG | SFFCDCGAKE | DGSCLALVKR | TPSSGMSSTM | KESAFQSEPR | ||||
ISESLVRHAS | TSSPADKAKV | TISDGKVADE | EKPKKSSLCR | TVEGCREELQ | ||||
NQANFSFAPL | VLDMLNFLMD | AIQTNFQQAS | AVGSSSRAQQ | ALSELHTVEK | ||||
AVEMTDQLMV | PTLGSQEGAF | ENVRMNYSGD | QGQTIRQLIS | AHVLRRVAMC | ||||
VLSSPHGRRQ | HLAVSHEKGK | ITVLQLSALL | KQADSSKRKL | TLTRLASAPV | ||||
PFTVLSLTGN | PCKEDYLAVC | GLKDCHVLTF | SSSGSVSDHL | VLHPQLATGN | ||||
FIIKAVWLPG | SQTELAIVTA | DFVKIYDLCV | DALSPTFYFL | LPSSKIRDVT | ||||
FLFNEEGKNI | IVIMSSAGYI | YTQLMEEASS | AQQGPFYVTN | VLEINHEDLK | ||||
DSNSQVAGGG | VSVYYSHVLQ | MLFFSYCQGK | SFAATISRTT | LEVLQLFPIN | ||||
IKSSNGGSKT | SPALCQWSEV | MNHPGLVCCV | QQTTGVPLVV | MVKPDTFLIQ | ||||
EIKTLPAKAK | IQDMVAIRHT | ACNEQQRTTM | ILLCEDGSLR | IYMANVENTS | ||||
YWLQPSLQPS | SVISIMKPVR | KRKTATITTR | TSSQVTFPID | FFEHNQQLTD | ||||
VEFGGNDLLQ | VYNAQQIKHR | LNSTGMYVAN | TKPGGFTIEI | SNNNSTMVMT | ||||
GMRIQIGTQA | IERAPSYIEI | FGRTMQLNLS | RSRWFDFPFT | REEALQADKK | ||||
LNLFIGASVD | PAGVTMIDAV | KIYGKTKEQF | GWPDEPPEEF | PSASVSNICP | ||||
SNLNQSNGTG | DSDSAAPTTT | SGTVLERLVV | SSLEALESCF | AVGPIIEKER | ||||
NKNAAQELAT | LLLSLPAPAS | VQQQSKSLLA | SLHTSRSAYH | SHKDQALLSK | ||||
AVQCLNTSSK | EGKDLDPEVF | QRLVITARSI | AIMRPNNLVH | FTESKLPQME | ||||
TEGMDEGKEP | QKQLEGDCCS | FITQLVNHFW | KLHASKPKNA | FLAPACLPGL | ||||
THIEATVNAL | VDIIHGYCTC | ELDCINTASK | IYMQMLLCPD | PAVSFSCKQA | ||||
LIRVLRPRNK | RRHVTLPSSP | RSNTPMGDKD | DDDDDDADEK | MQSSGIPNGG | ||||
HIRQESQEQS | EVDHGDFEMV | SESMVLETAE | NVNNGNPSPL | EALLAGAEGF | ||||
PPMLDIPPDA | DDETMVELAI | ALSLQQDQQG | SSSSALGLQS | LGLSGQAPSS | ||||
SSLDAGTLSD | TTASAPASDD | EGSTAATDGS | TLRTSPADHG | GSVGSESGGS | ||||
AVDSVAGEHS | VSGRSSAYGD | ATAEGHPAGP | GSVSSSTGAI | STTTGHQEGD | ||||
GSEGEGEGET | EGDVHTSNRL | HMVRLMLLER | LLQTLPQLRN | VGGVRAIPYM | ||||
QVILMLTTDL | DGEDEKDKGA | LDNLLSQLIA | ELGMDKKDVS | KKNERSALNE | ||||
VHLVVMRLLS | VFMSRTKSGS | KSSICESSSL | ISSATAAALL | SSGAVDYCLH | ||||
VLKSLLEYWK | SQQNDEEPVA | TSQLLKPHTT | SSPPDMSPFF | LRQYVKGHAA | ||||
DVFEAYTQLL | TEMVLRLPYQ | IKKITDTNSR | IPPPVFDHSW | FYFLSEYLMI | ||||
QQTPFVRRQV | RKLLLFICGS | KEKYRQLRDL | HTLDSHVRGI | KKLLEEQGIF | ||||
LRASVVTASS | GSALQYDTLI | SLMEHLKACA | EIAAQRTINW | QKFCIKDDSV | ||||
LYFLLQVSFL | VDEGVSPVLL | QLLSCALCGS | KVLAALAASS | GSSSASSSSA | ||||
PVAASSGQAT | TQSKSSTKKS | KKEEKEKEKD | GETSGSQEDQ | LCTALVNQLN | ||||
KFADKETLIQ | FLRCFLLESN | SSSVRWQAHC | LTLHIYRNSS | KSQQELLLDL | ||||
MWSIWPELPA | YGRKAAQFVD | LLGYFSLKTP | QTEKKLKEYS | QKAVEILRTQ | ||||
NHILTNHPNS | NIYNTLSGLV | EFDGYYLESD | PCLVCNNPEV | PFCYIKLSSI | ||||
KVDTRYTTTQ | QVVKLIGSHT | ISKVTVKIGD | LKRTKMVRTI | NLYYNNRTVQ | ||||
AIVELKNKPA | RWHKAKKVQL | TPGQTEVKID | LPLPIVASNL | MIEFADFYEN | ||||
YQASTETLQC | PRCSASVPAN | PGVCGNCGEN | VYQCHKCRSI | NYDEKDPFLC | ||||
NACGFCKYAR | FDFMLYAKPC | CAVDPIENEE | DRKKAVSNIN | TLLDKADRVY | ||||
HQLMGHRPQL | ENLLCKVNEA | APEKPQDDSG | TAGGISSTSA | SVNRYILQLA | ||||
QEYCGDCKNS | FDELSKIIQK | VFASRKELLE | YDLQQREAAT | KSSRTSVQPT | ||||
FTASQYRALS | VLGCGHTSST | KCYGCASAVT | EHCITLLRAL | ATNPALRHIL | ||||
VSQGLIRELF | DYNLRRGAAA | MREEVRQLMC | LLTRDNPEAT | QQMNDLIIGK | ||||
VSTALKGHWA | NPDLASSLQY | EMLLLTDSIS | KEDSCWELRL | RCALSLFLMA | ||||
VNIKTPVVVE | NITLMCLRIL | QKLIKPPAPT | SKKNKDVPVE | ALTTVKPYCN | ||||
EIHAQAQLWL | KRDPKASYDA | WKKCLPIRGI | DGNGKAPSKS | ELRHLYLTEK | ||||
YVWRWKQFLS | RRGKRTSPLD | LKLGHNNWLR | QVLFTPATQA | ARQAACTIVE | ||||
ALATIPSRKQ | QVLDLLTSYL | DELSIAGECA | AEYLALYQKL | ITSAHWKVYL | ||||
AARGVLPYVG | NLITKEIARL | LALEEATLST | DLQQGYALKS | LTGLLSSFVE | ||||
VESIKRHFKS | RLVGTVLNGY | LCLRKLVVQR | TKLIDETQDM | LLEMLEDMTT | ||||
GTESETKAFM | AVCIETAKRY | NLDDYRTPVF | IFERLCSIIY | PEENEVTEFF | ||||
VTLEKDPQQE | DFLQGRMPGN | PYSSNEPGIG | PLMRDIKNKI | CQDCDLVALL | ||||
EDDSGMELLV | NNKIISLDLP | VAEVYKKVWC | TTNEGEPMRI | VYRMRGLLGD | ||||
ATEEFIESLD | STTDEEEDEE | EVYKMAGVMA | QCGGLECMLN | RLAGIRDFKQ | ||||
GRHLLTVLLK | LFSYCVKVKV | NRQQLVKLEM | NTLNVMLGTL | NLALVAEQES | ||||
KDSGGAAVAE | QVLSIMEIIL | DESNAEPLSE | DKGNLLLTGD | KDQLVMLLDQ | ||||
INSTFVRSNP | SVLQGLLRII | PYLSFGEVEK | MQILVERFKP | YCNFDKYDED | ||||
HSGDDKVFLD | CFCKIAAGIK | NNSNGHQLKD | LILQKGITQN | ALDYMKKHIP | ||||
SAKNLDADIW | KKFLSRPALP | FILRLLRGLA | IQHPGTQVLI | GTDSIPNLHK | ||||
LEQVSSDEGI | GTLAENLLEA | LREHPDVNKK | IDAARRETRA | EKKRMAMAMR | ||||
QKALGTLGMT | TNEKGQVVTK | TALLKQMEEL | IEEPGLTCCI | CREGYKFQPT | ||||
KVLGIYTFTK | RVALEEMENK | PRKQQGYSTV | SHFNIVHYDC | HLAAVRLARG | ||||
REEWESAALQ | NANTKCNGLL | PVWGPHVPES | AFATCLARHN | TYLQECTGQR | ||||
EPTYQLNIHD | IKLLFLRFAM | EQSFSADTGG | GGRESNIHLI | PYIIHTVLYV | ||||
LNTTRATSRE | EKNLQGFLEQ | PKEKWVESAF | EVDGPYYFTV | LALHILPPEQ | ||||
WRATRVEILR | RLLVTSQARA | VAPGGATRLT | DKAVKDYSAY | RSSLLFWALV | ||||
DLIYNMFKKV | PTSNTEGGWS | CSLAEYIRHN | DMPIYEAADK | ALKTFQEEFM | ||||
PVETFSEFLD | VAGLLSEITD | PESFLKDLLN | SVP |
Reference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000127481 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000066036 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S (Dec 2003). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
- ^ Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O (Apr 2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
- ^ Tasaki T, Mulder LC, Iwamatsu A, Lee MJ, Davydov IV, Varshavsky A, Muesing M, Kwon YT (Aug 2005). "A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons". Mol Cell Biol. 25 (16): 7120–7136. doi:10.1128/MCB.25.16.7120-7136.2005. PMC 1190250. PMID 16055722.
- ^ "Entrez Gene: ZUBR1 zinc finger, UBR1 type 1".
- ^ "UniProt, Q5T4S7" (jezik: eng.). Pristupljeno 1. 12. 2021.CS1 održavanje: nepoznati jezik (link)
Dopunska literatura
uredi- Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–113. doi:10.1006/abio.1996.0138. PMID 8619474.
- Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
- Seki N, Ohira M, Nagase T, et al. (1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–349. doi:10.1093/dnares/4.5.345. PMID 9455484.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Huh KW, DeMasi J, Ogawa H, et al. (2005). "Association of the human papillomavirus type 16 E7 oncoprotein with the 600-kDa retinoblastoma protein-associated factor, p600". Proc. Natl. Acad. Sci. U.S.A. 102 (32): 11492–11497. Bibcode:2005PNAS..10211492H. doi:10.1073/pnas.0505337102. PMC 1182135. PMID 16061792.
- Nakatani Y, Konishi H, Vassilev A, et al. (2005). "p600, a unique protein required for membrane morphogenesis and cell survival". Proc. Natl. Acad. Sci. U.S.A. 102 (42): 15093–15098. doi:10.1073/pnas.0507458102. PMC 1247991. PMID 16214886.
- Lennerz V, Fatho M, Gentilini C, et al. (2005). "The response of autologous T cells to a human melanoma is dominated by mutated neoantigens". Proc. Natl. Acad. Sci. U.S.A. 102 (44): 16013–16018. Bibcode:2005PNAS..10216013L. doi:10.1073/pnas.0500090102. PMC 1266037. PMID 16247014.
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.