UAP1

UAP1
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	1JV1, 1JV3, 1JVD, 1JVG
Identifikatori
Aliasi	UAP1
Vanjski ID-jevi	OMIM: 602862 MGI: 1334459 HomoloGene: 2342 GeneCards: UAP1
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	162,601,240 bp
Lokacija gena (miš)
Hrom.	Hromosom 1 (miš)
Kraj	170,002,526 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• aktivnost sa transferazom; • uridylyltransferase activity; • nucleotidyltransferase activity; • carbohydrate binding; • vezivanje identičnih proteina; • UDP-N-acetylglucosamine diphosphorylase activity;
Ćelijska komponenta	• ćelijska membrana; • nukleoplazma; • citoplazma; • citosol;
Biološki proces	• UDP-N-acetylglucosamine metabolic process; • metabolizam; • UDP-N-acetylglucosamine biosynthetic process;
	Izvori:Amigo / QuickGO
Ortolozi
	6675
	107652
	ENSG00000117143
	ENSMUSG00000026670
	Q16222
	Q91YN5
NM_003115; NM_001324113; NM_001324114; NM_001324115; NM_001324116;
	NM_001324117; NM_001388401; NM_001388402; NM_001399790; NM_001399791; NM_001399792; NM_001399793
	NM_133806; NM_001305045; NM_001305046
NP_001311042; NP_001311043; NP_001311044; NP_001311045; NP_001311046;
	NP_003106
	NP_001291974; NP_001291975; NP_598567
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

UDP-N-acetilheksozamin pirofosforilaza je enzim koji je kod ljudi kodiran genom UAP1 sa hromosoma 1.^[5]^[6]^[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 522 aminokiseline, a molekulska težina 58.769 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MNINDLKLTL	SKAGQEHLLR	FWNELEEAQQ	VELYAELQAM	NFEELNFFFQ
KAIEGFNQSS	HQKNVDARME	PVPREVLGSA	TRDQDQLQAW	ESEGLFQISQ
NKVAVLLLAG	GQGTRLGVAY	PKGMYDVGLP	SRKTLFQIQA	ERILKLQQVA
EKYYGNKCII	PWYIMTSGRT	MESTKEFFTK	HKYFGLKKEN	VIFFQQGMLP
AMSFDGKIIL	EEKNKVSMAP	DGNGGLYRAL	AAQNIVEDME	QRGIWSIHVY
CVDNILVKVA	DPRFIGFCIQ	KGADCGAKVV	EKTNPTEPVG	VVCRVDGVYQ
VVEYSEISLA	TAQKRSSDGR	LLFNAGNIAN	HFFTVPFLRD	VVNVYEPQLQ
HHVAQKKIPY	VDTQGQLIKP	DKPNGIKMEK	FVFDIFQFAK	KFVVYEVLRE
DEFSPLKNAD	SQNGKDNPTT	ARHALMSLHH	CWVLNAGGHF	IDENGSRLPA
IPRSATNGKS	ETITADVNHN	LKDANDVPIQ	CEISPLISYA	GEGLESYVAD
KEFHAPLIID	ENGVHELVKN	GI

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000117143 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026670 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mio T, Yabe T, Arisawa M, Yamada-Okabe H (Jul 1998). "The eukaryotic UDP-N-acetylglucosamine pyrophosphorylases. Gene cloning, protein expression, and catalytic mechanism". J Biol Chem. 273 (23): 14392–7. doi:10.1074/jbc.273.23.14392. PMID 9603950.
^ Diekman AB, Goldberg E (Aug 1994). "Characterization of a human antigen with sera from infertile patients". Biol Reprod. 50 (5): 1087–93. doi:10.1095/biolreprod50.5.1087. PMID 8025165.
^ "Entrez Gene: UAP1 UDP-N-acteylglucosamine pyrophosphorylase 1".
^ "UniProt, Q16222" (jezik: en.). Pristupljeno 13. 12. 2021.CS1 održavanje: nepoznati jezik (link)

Dopunska literatura

Diekman AB, Olson G, Goldberg E (1998). "Expression of the human antigen SPAG2 in the testis and localization to the outer dense fibers in spermatozoa". Mol. Reprod. Dev. 50 (3): 284–93. doi:10.1002/(SICI)1098-2795(199807)50:3<284::AID-MRD4>3.0.CO;2-F. PMID 9621304.
Wang-Gillam A, Pastuszak I, Elbein AD (1998). "A 17-amino acid insert changes UDP-N-acetylhexosamine pyrophosphorylase specificity from UDP-GalNAc to UDP-GlcNAc". J. Biol. Chem. 273 (42): 27055–7. doi:10.1074/jbc.273.42.27055. PMID 9765219.
Peneff C, Ferrari P, Charrier V, et al. (2002). "Crystal structures of two human pyrophosphorylase isoforms in complexes with UDPGlc(Gal)NAc: role of the alternatively spliced insert in the enzyme oligomeric assembly and active site architecture". EMBO J. 20 (22): 6191–202. doi:10.1093/emboj/20.22.6191. PMC 125729. PMID 11707391.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.

Vanjski linkovi

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000117143 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026670 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9603950-5] Mio T, Yabe T, Arisawa M, Yamada-Okabe H (Jul 1998). "The eukaryotic UDP-N-acetylglucosamine pyrophosphorylases. Gene cloning, protein expression, and catalytic mechanism". J Biol Chem. 273 (23): 14392–7. doi:10.1074/jbc.273.23.14392. PMID 9603950.

[pmid8025165-6] Diekman AB, Goldberg E (Aug 1994). "Characterization of a human antigen with sera from infertile patients". Biol Reprod. 50 (5): 1087–93. doi:10.1095/biolreprod50.5.1087. PMID 8025165.

[entrez-7] "Entrez Gene: UAP1 UDP-N-acteylglucosamine pyrophosphorylase 1".

[UniProt-8] "UniProt, Q16222" (jezik: en.). Pristupljeno 13. 12. 2021.CS1 održavanje: nepoznati jezik (link)

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