TTLL1

TTLL1
Identifikatori
Aliasi	TTLL1
Vanjski ID-jevi	OMIM: 608955 MGI: 2443047 HomoloGene: 8174 GeneCards: TTLL1
Lokacija gena (čovjek)
Hrom.	Hromosom 22 (čovjek)
Kraj	43,089,419 bp
Lokacija gena (miš)
Hrom.	Hromosom 15 (miš)
Kraj	83,395,094 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• nucleotide binding; • ligase activity; • ATP binding; • tubulin-glutamic acid ligase activity;
Ćelijska komponenta	• citoplazma; • Mikrotubula; • citoskelet; • extracellular region;
Biološki proces	• epithelial cilium movement involved in extracellular fluid movement; • protein polyglutamylation; • axoneme assembly; • sperm axoneme assembly;
	Izvori:Amigo / QuickGO
Ortolozi
	25809
	319953
	ENSG00000100271
	ENSMUSG00000022442
	O95922
	Q91V51
	NM_001008572; NM_012263
	NM_178869; NM_001357953
	NP_036395
	NP_849200; NP_001344882
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Vjerovatna tubulin-poliglutamilaza TTLL1 jest enzim koji je kod ljudi kodiran genom TTLL1 sa hromosoma 22.^[5]^[6]^[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 423 aminokiseline, a molekulska težina 48.988 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MAGKVKWVTD	IEKSVLINNF	EKRGWVQVTE	NEDWNFYWMS	VQTIRNVFSV
EAGYRLSDDQ	IVNHFPNHYE	LTRKDLMVKN	IKRYRKELEK	EGSPLAEKDE
NGKYLYLDFV	PVTYMLPADY	NLFVEEFRKS	PSSTWIMKPC	GKAQGKGIFL
INKLSQIKKW	SRDSKTSSFV	SQSNKEAYVI	SLYINNPLLI	GGRKFDLRLY
VLVSTYRPLR	CYMYKLGFCR	FCTVKYTPST	SELDNMFVHL	TNVAIQKHGE
DYNHIHGGKW	TVSNLRLYLE	STRGKEVTSK	LFDEIHWIIV	QSLKAVAPVM
NNDKHCFECY	GYDIIIDDKL	KPWLIEVNAS	PSLTSSTAND	RILKYNLIND
TLNIAVPNGE	IPDCKWNKSP	PKEVLGNYEI	LYDEELAQGD	GADRELRSRQ
GQSLGPRAGR	SRDSGRAVLT	TWK

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100271 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022442 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
^ Trichet V, Ruault M, Roizes G, De Sario A (Dec 2000). "Characterization of the human tubulin tyrosine ligase-like 1 gene (TTLL1) mapping to 22q13.1". Gene. 257 (1): 109–17. doi:10.1016/S0378-1119(00)00383-8. PMID 11054573.
^ ^a ^b "Entrez Gene: TTLL1 tubulin tyrosine ligase-like family, member 1".

Dopunska literatura

Nagase T, Seki N, Ishikawa K, et al. (1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Collins JE, Goward ME, Cole CG, et al. (2003). "Reevaluating Human Gene Annotation: A Second-Generation Analysis of Chromosome 22". Genome Res. 13 (1): 27–36. doi:10.1101/gr.695703. PMC 430954. PMID 12529303.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Janke C, Rogowski K, Wloga D, et al. (2005). "Tubulin polyglutamylase enzymes are members of the TTL domain protein family". Science. 308 (5729): 1758–62. doi:10.1126/science.1113010. PMID 15890843. S2CID 25798588.

Vanjski linkovi

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100271 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022442 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10591208-5] Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.

[pmid11054573-6] Trichet V, Ruault M, Roizes G, De Sario A (Dec 2000). "Characterization of the human tubulin tyrosine ligase-like 1 gene (TTLL1) mapping to 22q13.1". Gene. 257 (1): 109–17. doi:10.1016/S0378-1119(00)00383-8. PMID 11054573.

[entrez-7] "Entrez Gene: TTLL1 tubulin tyrosine ligase-like family, member 1".

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