TP53I3

TP53I3
Dostupne strukture
PDB	Pretraga Human UniProta: PDBe RCSB
Spisak PDB ID kodova
	2J8Z, 2OBY
Identifikatori
Aliasi	TP53I3
Vanjski ID-jevi	OMIM: 605171 HomoloGene: 36617 GeneCards: TP53I3
Lokacija gena (čovjek)
Hrom.	Hromosom 2 (čovjek)
Kraj	24,085,861 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• oxidoreductase activity; • protein homodimerization activity; • NADPH binding; • quinone binding; • NADPH:quinone reductase activity;
Ćelijska komponenta	• citosol;
Biološki proces	• NADP metabolic process; • regulation of apoptotic process;
	Izvori:Amigo / QuickGO
Ortolozi
	9540
	n/a
	ENSG00000115129
	n/a
	Q53FA7
	n/a
	NM_001206802; NM_004881; NM_147184
	n/a
	NP_001193731; NP_004872; NP_671713
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek

Navodna kinon-oksidoreduktaza jest enzim koji je kod ljudi kodiran genom TP53I3 sa hromosoma 2.^[3]^[4]^[5]^[6]

Amiokiselininska sekvenca

Dužina polipeptidnog lanca je 332 aminokiseline, a molekulska težina 35.536 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MLAVHFDKPG	GPENLYVKEV	AKPSPGEGEV	LLKVAASALN	RADLMQRQGQ
YDPPPGASNI	LGLEASGHVA	ELGPGCQGHW	KIGDTAMALL	PGGGQAQYVT
VPEGLLMPIP	EGLTLTQAAA	IPEAWLTAFQ	LLHLVGNVQA	GDYVLIHAGL
SGVGTAAIQL	TRMAGAIPLV	TAGSQKKLQM	AEKLGAAAGF	NYKKEDFSEA
TLKFTKGAGV	NLILDCIGGS	YWEKNVNCLA	LDGRWVLYGL	MGGGDINGPL
FSKLLFKRGS	LITSLLRSRD	NKYKQMLVNA	FTEQILPHFS	TEGPQRLLPV
LDRIYPVTEI	QEAHKYMEAN	KNIGKIVLEL	PQ

Funkcija

Protein koji je kodiran ovim genom sličan je oksidoreduktazama, enzimima uključenim u ćelijske odgovore na oksidativni stres i zračenje. Ovaj gen inducira tumorski supresor p53 i smatra se da je uključen u p53 posredovanu ćelijsku smrt. Sadrži konsenzusno vezujuće mjesto p53 u svom promotorskom području i nizvodnu pentanukleotidnu mikrosatelitsku sekvencu. Pokazalo se da P53 transkripcijski aktivira ovaj gen interakcijom sa nizvodnom pentanukleotidnom mikrosatelitskom sekvencom. Mikrosatelit je polimorfan, sa različitim brojem pentanukleotidnih ponavljanja u direktnoj korelaciji sa stepenom aktivacije transkripcije putem p53. Sugerirano je da mikrosatelitski polimorfizam može biti povezan s različitom osjetljivošću na kancer. Za ovaj gen su pronađene najmanje dvije varijante transkripta koje kodiraju isti protein.^[6]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115129 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Contente A, Dittmer A, Koch MC, Roth J, Dobbelstein M (Mar 2002). "A polymorphic microsatellite that mediates induction of PIG3 by p53". Nat Genet. 30 (3): 315–20. doi:10.1038/ng836. PMID 11919562. S2CID 19112465.
^ Flatt PM, Polyak K, Tang LJ, Scatena CD, Westfall MD, Rubinstein LA, Yu J, Kinzler KW, Vogelstein B, Hill DE, Pietenpol JA (Jul 2000). "p53-dependent expression of PIG3 during proliferation, genotoxic stress, and reversible growth arrest". Cancer Lett. 156 (1): 63–72. doi:10.1016/S0304-3835(00)00441-9. PMID 10840161.
^ Porte S, Valencia E, Yakovtseva EA, Borras E, Shafqat N, Debreczeny JE, Pike AC, Oppermann U, Farres J, Fita I, Pares X (Jun 2009). "Three-dimensional structure and enzymatic function of proapoptotic human p53-inducible quinone oxidoreductase PIG3". J Biol Chem. 284 (25): 17194–205. doi:10.1074/jbc.M109.001800. PMC 2719357. PMID 19349281.
^ ^a ^b "Entrez Gene: TP53I3 tumor protein p53 inducible protein 3".
^ "UniProt, Q53FA7" (jezik: engleski). Pristupljeno 15. 11. 2021.

Dopunska literatura

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Polyak K, Xia Y, Zweier JL, et al. (1997). "A model for p53-induced apoptosis". Nature. 389 (6648): 300–5. doi:10.1038/38525. PMID 9305847. S2CID 4429638.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Nicholls CD, Shields MA, Lee PW, et al. (2004). "UV-dependent alternative splicing uncouples p53 activity and PIG3 gene function through rapid proteolytic degradation". J. Biol. Chem. 279 (23): 24171–8. doi:10.1074/jbc.M401049200. PMID 15067011.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
Rohaly G, Chemnitz J, Dehde S, et al. (2005). "A novel human p53 isoform is an essential element of the ATR-intra-S phase checkpoint". Cell. 122 (1): 21–32. doi:10.1016/j.cell.2005.04.032. PMID 16009130. S2CID 2350226.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.

Vanjski linkovi

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115129 - Ensembl, maj 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11919562-3] Contente A, Dittmer A, Koch MC, Roth J, Dobbelstein M (Mar 2002). "A polymorphic microsatellite that mediates induction of PIG3 by p53". Nat Genet. 30 (3): 315–20. doi:10.1038/ng836. PMID 11919562. S2CID 19112465.

[pmid10840161-4] Flatt PM, Polyak K, Tang LJ, Scatena CD, Westfall MD, Rubinstein LA, Yu J, Kinzler KW, Vogelstein B, Hill DE, Pietenpol JA (Jul 2000). "p53-dependent expression of PIG3 during proliferation, genotoxic stress, and reversible growth arrest". Cancer Lett. 156 (1): 63–72. doi:10.1016/S0304-3835(00)00441-9. PMID 10840161.

[pmid19349281-5] Porte S, Valencia E, Yakovtseva EA, Borras E, Shafqat N, Debreczeny JE, Pike AC, Oppermann U, Farres J, Fita I, Pares X (Jun 2009). "Three-dimensional structure and enzymatic function of proapoptotic human p53-inducible quinone oxidoreductase PIG3". J Biol Chem. 284 (25): 17194–205. doi:10.1074/jbc.M109.001800. PMC 2719357. PMID 19349281.

[entrez-6] "Entrez Gene: TP53I3 tumor protein p53 inducible protein 3".

[UniProt-7] "UniProt, Q53FA7" (jezik: engleski). Pristupljeno 15. 11. 2021.

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