TNFSF12-TNFSF13
Superporodični faktor tumorske nekroze, ligandni članovi 12 i 13, znan i kao TNFSF12-TNFSF13, je ljudski gen.[5]
Ovaj gen pripada superporodici faktora tumorskih nekroza (TNFSF). Kodira hibridni protein sastavljen od citoplazmatskog i transmembranskog domena člana porodice 12, koji je spojen sa C-terminalnim domenom člana porodice 13. Hibridni protein je membranski protein i predstavlja receptor-vezujući domen člana porodice 13 na ćelijskoj površini. Podstiče cikluse ćelijskih linija T-limfoma i B-limfoma. Transkript iRNK translatiran je i eksprimiran u primarnim T-ćelijama i monocitima.[5]
Dužina polipeptidnog lanca je 249 aminokiselina, a molekulska težina 27.216.[6]
Aminokiselinska sekvenca
- Simboli
C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MAARRSQRRR | GRRGEPGTAL | LVPLALGLGL | ALACLGLLLA | VVSLGSRASL | ||||
| SAQEPAQEEL | VAEEDQDPSE | LNPQTEESQD | PAPFLNRLVR | PRRSAPKGRK | ||||
| TRARRAIAAH | YEVHPRPGQD | GAQAGVDGTV | SGWEEARINS | SSPLRYNRQI | ||||
| GEFIVTRAGL | YYLYCQVHFD | EGKAVYLKLD | LLVDGVLALR | CLEEFSATAA | ||||
| SSLGPQLRLC | QVSGLLALRP | GSSLRIRTLP | WAHLKAAPFL | TYFGLFQVH |
Reference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000248871 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018752 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: TNFSF12-TNFSF13 tumor necrosis factor (ligand) superfamily, member 12-member 13".
- ^ "UniProt, O43508". Pristupljeno 12. 6. 2021.
Dopunska literatura
uredi- Hahne M, Kataoka T, Schröter M, et al. (1998). "APRIL, a New Ligand of the Tumor Necrosis Factor Family, Stimulates Tumor Cell Growth". J. Exp. Med. 188 (6): 1185–90. doi:10.1084/jem.188.6.1185. PMC 2212534. PMID 9743536.
- Kelly K, Manos E, Jensen G, et al. (2000). "APRIL/TRDL-1, a tumor necrosis factor-like ligand, stimulates cell death". Cancer Res. 60 (4): 1021–7. PMID 10706119.
- Wu Y, Bressette D, Carrell JA, et al. (2001). "Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS". J. Biol. Chem. 275 (45): 35478–85. doi:10.1074/jbc.M005224200. PMID 10956646.
- Yu G, Boone T, Delaney J, et al. (2001). "APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity". Nat. Immunol. 1 (3): 252–6. doi:10.1038/79802. PMID 10973284. S2CID 6799584.
- López-Fraga M, Fernández R, Albar JP, Hahne M (2002). "Biologically active APRIL is secreted following intracellular processing in the Golgi apparatus by furin convertase". EMBO Rep. 2 (10): 945–51. doi:10.1093/embo-reports/kve198. PMC 1084076. PMID 11571266.
- Roschke V, Sosnovtseva S, Ward CD, et al. (2002). "BLyS and APRIL form biologically active heterotrimers that are expressed in patients with systemic immune-based rheumatic diseases". J. Immunol. 169 (8): 4314–21. doi:10.4049/jimmunol.169.8.4314. PMID 12370363.
- Pradet-Balade B, Medema JP, López-Fraga M, et al. (2002). "An endogenous hybrid mRNA encodes TWE-PRIL, a functional cell surface TWEAK–APRIL fusion protein". EMBO J. 21 (21): 5711–20. doi:10.1093/emboj/cdf565. PMC 131062. PMID 12411489.
- Hendriks J, Planelles L, de Jong-Odding J, et al. (2005). "Heparan sulfate proteoglycan binding promotes APRIL-induced tumor cell proliferation". Cell Death Differ. 12 (6): 637–48. doi:10.1038/sj.cdd.4401647. PMID 15846369.