TMEM59

TMEM59
Identifikatori
Aliasi	TMEM59
Vanjski ID-jevi	OMIM: 617084 MGI: 1929278 HomoloGene: 3583 GeneCards: TMEM59
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	54,053,504 bp
Lokacija gena (miš)
Hrom.	Hromosom 4 (miš)
Kraj	107,058,193 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• endopeptidase activity; • GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• integral component of membrane; • endozom; • late endosome; • Golđijev aparat; • late endosome membrane; • Golgi medial cisterna; • membrana; • Golđijeva membrana; • ćelijska membrana; • Golgi cis cisterna; • lysosomal membrane; • Golgi trans cisterna; • Lizozom; • Egzosom;
Biološki proces	• positive regulation of autophagy; • Proteoliza; • Autofagija; • negative regulation of protein processing; • negative regulation of protein localization to plasma membrane;
	Izvori:Amigo / QuickGO
Ortolozi
	9528
	56374
	ENSG00000116209
	ENSMUSG00000028618
	Q9BXS4
	Q9QY73
NM_001305043; NM_001305049; NM_001305050; NM_001305051; NM_001305052;
	NM_001305066; NM_004872
	NM_029565
NP_001291972; NP_001291978; NP_001291979; NP_001291980; NP_001291981;
	NP_001291995; NP_004863
	NP_083841
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Transmembranski protein 59 jest protein koji je kod ljudi kodiran genom TMEM59 sa hromosoma 1.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 323 aminokiseline, a molekulska težina 36.223 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MAAPKGSLWV	RTQLGLPPLL	LLTMALAGGS	GTASAEAFDS	VLGDTASCHR
ACQLTYPLHT	YPKEEELYAC	QRGCRLFSIC	QFVDDGIDLN	RTKLECESAC
TEAYSQSDEQ	YACHLGCQNQ	LPFAELRQEQ	LMSLMPKMHL	LFPLTLVRSF
WSDMMDSAQS	FITSSWTFYL	QADDGKIVIF	QSKPEIQYAP	HLEQEPTNLR
ESSLSKMSYL	QMRNSQAHRN	FLEDGESDGF	LRCLSLNSGW	ILTTTLVLSV
MVLLWICCAT	VATAVEQYVP	SEKLSIYGDL	EFMNEQKLNR	YPASSLVVVR
SKTEDHEEAG	PLPTKVNLAH	SEI

Funkcija

TMEM59 je protein vezan za membranu koji je lokaliziran na Golgijev aparat.^[8] Precizna funkcija TMEM59 nije poznata, ali je pokazano da ekspresija TMEM59 proteina inhibira Golgi glikozilaciju prekursora amiloidnog proteina (APP) i blokira cijepanje APP pomoću α- i β-amiloidno prekursorske proteinske sekrecije i stoga inhibira stvaranje beta-amiloidnog peptida koji formira amiloidne plakove kod Alzheimerove bolesti.^[8] Štaviše, TMEM59 je pokazalo se da potencira wnt signalizaciju promicanjem formiranja signalosomskog wnt receptora. Utvrđeno je da transmembranske interakcije između TMEM59 i wnt receptora Frizzled pokreću multimerizaciju receptora, što dovodi do poboljšane potencije i efikasnosti wnt-signalizacije.^[9]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000116209 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028618 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z (juli 1998). "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proceedings of the National Academy of Sciences of the United States of America. 95 (14): 8175–80. Bibcode:1998PNAS...95.8175M. doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160.
^ "Entrez Gene: TMEM59 transmembrane protein 59".
^ "UniProt, Q9BXS4" (jezik: en.). Pristupljeno 6. 12. 2021.CS1 održavanje: nepoznati jezik (link)
^ ^a ^b Ullrich S, Münch A, Neumann S, Kremmer E, Tatzelt J, Lichtenthaler SF (juli 2010). "The novel membrane protein TMEM59 modulates complex glycosylation, cell surface expression, and secretion of the amyloid precursor protein". The Journal of Biological Chemistry. 285 (27): 20664–74. doi:10.1074/jbc.M109.055608. PMC 2898310. PMID 20427278.
^ Gerlach JP, Jordens I, Tauriello DV, van 't Land-Kuper I, Bugter JM, Noordstra I, van der Kooij J, Low TY, Pimentel-Muiños FX, Xanthakis D, Fenderico N, Rabouille C, Heck AJ, Egan DA, Maurice MM (april 2018). "TMEM59 potentiates Wnt signaling by promoting signalosome formation". Proceedings of the National Academy of Sciences of the United States of America. 115 (17): E3996–E4005. doi:10.1073/pnas.1721321115. PMC 5924918. PMID 29632210.

Dopunska literatura

Maruyama K, Sugano S (januar 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (oktobar 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (oktobar 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (oktobar 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000116209 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028618 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9653160-5] Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z (juli 1998). "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proceedings of the National Academy of Sciences of the United States of America. 95 (14): 8175–80. Bibcode:1998PNAS...95.8175M. doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160.

[entrez-6] "Entrez Gene: TMEM59 transmembrane protein 59".

[UniProt-7] "UniProt, Q9BXS4" (jezik: en.). Pristupljeno 6. 12. 2021.CS1 održavanje: nepoznati jezik (link)

[Ullrich_2010-8] Ullrich S, Münch A, Neumann S, Kremmer E, Tatzelt J, Lichtenthaler SF (juli 2010). "The novel membrane protein TMEM59 modulates complex glycosylation, cell surface expression, and secretion of the amyloid precursor protein". The Journal of Biological Chemistry. 285 (27): 20664–74. doi:10.1074/jbc.M109.055608. PMC 2898310. PMID 20427278.

[9] Gerlach JP, Jordens I, Tauriello DV, van 't Land-Kuper I, Bugter JM, Noordstra I, van der Kooij J, Low TY, Pimentel-Muiños FX, Xanthakis D, Fenderico N, Rabouille C, Heck AJ, Egan DA, Maurice MM (april 2018). "TMEM59 potentiates Wnt signaling by promoting signalosome formation". Proceedings of the National Academy of Sciences of the United States of America. 115 (17): E3996–E4005. doi:10.1073/pnas.1721321115. PMC 5924918. PMID 29632210.

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