TM4SF1

TM4SF1
Identifikatori
Aliasi	TM4SF1
Vanjski ID-jevi	OMIM: 191155 MGI: 104678 HomoloGene: 7409 GeneCards: TM4SF1
Lokacija gena (čovjek)
Hrom.	Hromosom 3 (čovjek)
Kraj	149,377,692 bp
Lokacija gena (miš)
Hrom.	Hromosom 3 (miš)
Kraj	57,209,409 bp
Obrazac RNK ekspresije
	; ; ; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • molekularna funkcija;
Ćelijska komponenta	• integral component of plasma membrane; • membrana; • integral component of membrane;
Biološki proces	• GO:0022610 biološki proces; • blastocyst formation;
	Izvori:Amigo / QuickGO
Ortolozi
	4071
	17112
	ENSG00000169908
	ENSMUSG00000027800
	P30408
	Q64302
	NM_014220
	NM_008536; NM_001355130
	NP_055035
	NP_032562; NP_001342059
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Član 1 porodice 4 L6 transmembranskih proteina jest protein koji je kod ljudi kodiran genom TM4SF1 sa hromosoma 3.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 202 aminokiseline, а molekulska težina 21.632 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MCYGKCARCI	GHSLVGLALL	CIAANILLYF	PNGETKYASE	NHLSRFVWFF
SGIVGGGLLM	LLPAFVFIGL	EQDDCCGCCG	HENCGKRCAM	LSSVLAALIG
IAGSGYCVIV	AALGLAEGPL	CLDSLGQWNY	TFASTEGQYL	LDTSTWSECT
EPKHIVEWNV	SLFSILLALG	GIEFILCLIQ	VINGVLGGIC	GFCCSHQQQY
DC

Funkcija

Protein kodiran ovim genom je član natporodice 4 transmembranskih proteina, poznate i kao porodica tetraspanina . Većina ovih članova su proteini na površini ćelije koje karakteriše prisustvo četiri hidrofobna domena. Proteini posreduju u događajima transdukcije signala koji imaju ulogu u regulaciji razvoja, aktivacije, rasta i pokretljivosti ćelija. Ovaj kodirani protein je antigen ćelijske površine i visoko je eksprimiran u različitim karcinomima.^[6]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000169908 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027800 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Marken JS, Schieven GL, Hellström I, Hellström KE, Aruffo A (Apr 1992). "Cloning and expression of the tumor-associated antigen L6". Proceedings of the National Academy of Sciences of the United States of America. 89 (8): 3503–7. doi:10.1073/pnas.89.8.3503. PMC 48896. PMID 1565644.
^ ^a ^b "Entrez Gene: TM4SF1 transmembrane 4 L six family member 1".
^ "UniProt, P30408" (jezik: engleski). Pristupljeno 2. 11. 2021.

Dopunska literatura

Berditchevski F (Dec 2001). "Complexes of tetraspanins with integrins: more than meets the eye". Journal of Cell Science. 114 (Pt 23): 4143–51. doi:10.1242/jcs.114.23.4143. PMID 11739647.
Marken JS, Bajorath J, Edwards CP, Farr AG, Schieven GL, Hellström I, Hellström KE, Aruffo A (Mar 1994). "Membrane topology of the L6 antigen and identification of the protein epitope recognized by the L6 monoclonal antibody". The Journal of Biological Chemistry. 269 (10): 7397–401. doi:10.1016/S0021-9258(17)37298-8. PMID 7510285.
Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, Bieber FR, Morton CC (Sep 1994). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.
Virtaneva KI, Emi N, Marken JS, Aruffo A, Jones C, Spurr NK, Schröder JP (1994). "Chromosomal localization of three human genes coding for A15, L6, and S5.7 (TAPA1): all members of the transmembrane 4 superfamily of proteins". Immunogenetics. 39 (5): 329–34. doi:10.1007/BF00189229. PMID 8168850. S2CID 22971645.
Borrell-Pagès M, Fernández-Larrea J, Borroto A, Rojo F, Baselga J, Arribas J (Dec 2000). "The carboxy-terminal cysteine of the tetraspanin L6 antigen is required for its interaction with SITAC, a novel PDZ protein". Molecular Biology of the Cell. 11 (12): 4217–25. doi:10.1091/mbc.11.12.4217. PMC 15068. PMID 11102519.
Storim J, Friedl P, Schaefer BM, Bechtel M, Wallich R, Kramer MD, Reinartz J (Jul 2001). "Molecular and functional characterization of the four-transmembrane molecule l6 in epidermal keratinocytes". Experimental Cell Research. 267 (2): 233–42. doi:10.1006/excr.2001.5250. PMID 11426942.
Kaneko R, Tsuji N, Kamagata C, Endoh T, Nakamura M, Kobayashi D, Yagihashi A, Watanabe N (Dec 2001). "Amount of expression of the tumor-associated antigen L6 gene and transmembrane 4 superfamily member 5 gene in gastric cancers and gastric mucosa". The American Journal of Gastroenterology. 96 (12): 3457–8. PMID 11774983.
Kao YR, Shih JY, Wen WC, Ko YP, Chen BM, Chan YL, Chu YW, Yang PC, Wu CW, Roffler SR (Jul 2003). "Tumor-associated antigen L6 and the invasion of human lung cancer cells". Clinical Cancer Research. 9 (7): 2807–16. PMID 12855661.
Chang YW, Chen SC, Cheng EC, Ko YP, Lin YC, Kao YR, Tsay YG, Yang PC, Wu CW, Roffler SR (Aug 2005). "CD13 (aminopeptidase N) can associate with tumor-associated antigen L6 and enhance the motility of human lung cancer cells". International Journal of Cancer. 116 (2): 243–52. doi:10.1002/ijc.21089. PMID 15812828. S2CID 26010618.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
Visintin A, Knowlton K, Tyminski E, Lin CI, Zheng X, Marquette K, Jain S, Tchistiakova L, Li D, O'Donnell CJ, Maderna A, Cao X, Dunn R, Snyder W, Abraham AK, Leal M, Shetty S, Barry A, Zawel L, Coyle AJ, Dvorak HF, Jaminet SC (Jun 2015). "Novel Anti-TM4SF1 Antibody Drug Conjugates with Activity against Tumor Cells and Tumor Vasculature". Molecular Cancer Therapeutics. 14 (8): 1868–76. doi:10.1158/1535-7163.MCT-15-0188. PMID 26089370.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000169908 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027800 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Marken JS, Schieven GL, Hellström I, Hellström KE, Aruffo A (Apr 1992). "Cloning and expression of the tumor-associated antigen L6". Proceedings of the National Academy of Sciences of the United States of America. 89 (8): 3503–7. doi:10.1073/pnas.89.8.3503. PMC 48896. PMID 1565644.

[entrez-6] "Entrez Gene: TM4SF1 transmembrane 4 L six family member 1".

[UniProt-7] "UniProt, P30408" (jezik: engleski). Pristupljeno 2. 11. 2021.

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