TDGF1

TDGF1
Identifikatori
Aliasi	TDGF1
Vanjski ID-jevi	MGI: 98658 HomoloGene: 2416 GeneCards: TDGF1
Lokacija gena (čovjek)
Hrom.	Hromosom 3 (čovjek)
Kraj	46,582,457 bp
Lokacija gena (miš)
Hrom.	Hromosom 9 (miš)
Kraj	110,775,226 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • growth factor activity; • signaling receptor binding; • nodal binding; • activin receptor binding;
Ćelijska komponenta	• membrana; • ćelijska membrana; • cell surface; • apical plasma membrane; • Lipidni splav; • anchored component of membrane; • extrinsic component of plasma membrane; • Vanćelijsko; • extracellular region;
Biološki proces	• Ćelijska diferencijacija; • cellular response to interleukin-6; • epidermal growth factor receptor signaling pathway; • somatic stem cell population maintenance; • positive regulation of cell migration; • cellular response to hepatocyte growth factor stimulus; • cellular response to tumor necrosis factor; • negative regulation of apoptotic process; • cellular response to fibroblast growth factor stimulus; • morphogenesis of a branching structure; • cell migration involved in sprouting angiogenesis; • mammary gland development; • positive regulation of endothelial cell migration; • cellular response to epidermal growth factor stimulus; • heart development; • regulation of signal transduction; • GO:0035404 peptidyl-serine phosphorylation; • positive regulation of cell population proliferation; • positive regulation of peptidyl-tyrosine phosphorylation; • cellular response to interferon-gamma; • anterior/posterior axis specification, embryo; • regulation of signaling receptor activity; • embryo development ending in birth or egg hatching; • determination of left/right symmetry; • anterior/posterior pattern specification; • BMP signaling pathway; • nodal signaling pathway; • GO:1903374 anatomical structure development;
	Izvori:Amigo / QuickGO
Ortolozi
	6997
	21667
	ENSG00000241186
	ENSMUSG00000032494
	P13385
	P51865
	NM_003212; NM_001174136
	NM_011562
	NP_001167607; NP_003203
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Transmembranski protein 158 jest protein koji je kod ljudi kodiran genom TMEM158 sa hromosoma 3.^[5]^[6]^[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 300 aminokiselina, а molekulska težina 30.404 Da.^[8].

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MLPLLAALLA	AACPLPPVRG	GAADAPGLLG	VPSNASVNAS	SADEPIAPRL
LASAAPGPPE	RPGPEEAAAA	AAPCNISVQR	QMLSSLLVRW	GRPRGFQCDL
LLFSTNAHGR	AFFAAAFHRV	GPPLLIEHLG	LAAGGAQQDL	RLCVGCGWVR
GRRTGRLRPA	AAPSAAAATA	GAPTALPAYP	AAEPPGPLWL	QGEPLHFCCL
DFSLEELQGE	PGWRLNRKPI	ESTLVACFMT	LVIVVWSVAA	LIWPVPIIAG
FLPNGMEQRR	TTASTTAATP	AAVPAGTTAA	AAAAAAAAAA	AAVTSGVATK

Funkcija

Kodirani protein je sličan pacovskom receptoru ćelijske površine za koji je predloženo da funkcionira u neuronskom putu preživljavanja^[7]

Konstitutivna aktivacija Ras puta pokreće ireverzibilno zaustavljanje proliferacije koje podsjeća na replikativnu senescenciju. Transkripcija ovog gena je pojačana kao odgovor na aktivaciju Ras puta, ali ne pod drugim uvjetima koji induciraju starenje .

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000241186 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032494 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hama T, Maruyama M, Katoh-Semba R, Takizawa M, Iwashima M, Nara K (Aug 2001). "Identification and molecular cloning of a novel brain-specific receptor protein that binds to brain injury-derived neurotrophic peptide. Possible role for neuronal survival". J Biol Chem. 276 (34): 31929–35. doi:10.1074/jbc.M100617200. PMID 11399754.
^ Barradas M, Gonos ES, Zebedee Z, Kolettas E, Petropoulou C, Delgado MD, Leon J, Hara E, Serrano M (Feb 2002). "Identification of a candidate tumor-suppressor gene specifically activated during Ras-induced senescence". Exp Cell Res. 273 (2): 127–37. doi:10.1006/excr.2001.5434. PMID 11822868.
^ ^a ^b "Entrez Gene: TMEM158 transmembrane protein 158".
^ "UniProt, Q8WZ71" (jezik: eng). Pristupljeno 6. 11. 2021.CS1 održavanje: nepoznati jezik (link)

Dopunska literatura

Iglesias D, Fernández-Peralta AM, Nejda N, et al. (2006). "RIS1, a gene with trinucleotide repeats, is a target in the mutator pathway of colorectal carcinogenesis". Cancer Genet. Cytogenet. 167 (2): 138–44. doi:10.1016/j.cancergencyto.2005.12.002. PMID 16737913.
Zirn B, Samans B, Wittmann S, et al. (2006). "Target genes of the WNT/beta-catenin pathway in Wilms tumors". Genes Chromosomes Cancer. 45 (6): 565–74. doi:10.1002/gcc.20319. PMID 16575872. S2CID 84406946.
Silva J, Silva JM, Barradas M, et al. (2006). "Analysis of the candidate tumor suppressor Ris-1 in primary human breast carcinomas". Mutat. Res. 594 (1–2): 78–85. doi:10.1016/j.mrfmmm.2005.07.017. PMID 16280139.
Sussan TE, Pletcher MT, Murakami Y, Reeves RH (2006). "Tumor suppressor in lung cancer 1 (TSLC1) alters tumorigenic growth properties and gene expression". Mol. Cancer. 4: 28. doi:10.1186/1476-4598-4-28. PMC 1208945. PMID 16083501.
Verlinden I, Janssens J, Raus J, Michiels L (2005). "Microdissection and SAGE as a combined tool to reveal gene expression in ductal carcinoma in situ of the breast". Mol. Carcinog. 41 (4): 197–206. doi:10.1002/mc.20055. PMID 15486950. S2CID 19850341.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000241186 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032494 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11399754-5] Hama T, Maruyama M, Katoh-Semba R, Takizawa M, Iwashima M, Nara K (Aug 2001). "Identification and molecular cloning of a novel brain-specific receptor protein that binds to brain injury-derived neurotrophic peptide. Possible role for neuronal survival". J Biol Chem. 276 (34): 31929–35. doi:10.1074/jbc.M100617200. PMID 11399754.

[pmid11822868-6] Barradas M, Gonos ES, Zebedee Z, Kolettas E, Petropoulou C, Delgado MD, Leon J, Hara E, Serrano M (Feb 2002). "Identification of a candidate tumor-suppressor gene specifically activated during Ras-induced senescence". Exp Cell Res. 273 (2): 127–37. doi:10.1006/excr.2001.5434. PMID 11822868.

[entrez-7] "Entrez Gene: TMEM158 transmembrane protein 158".

[UniProt-8] "UniProt, Q8WZ71" (jezik: eng). Pristupljeno 6. 11. 2021.CS1 održavanje: nepoznati jezik (link)

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