TARP

Protein TCR gama alternativnog okvira čitanja, znan i kao TARP, je ljudski gen.

TARP
Identifikatori
Aliasi	TARP
Vanjski ID-jevi	OMIM: 609642 HomoloGene: 128237 GeneCards: TARP
Lokacija gena (čovjek) Hrom. Hromosom 7 (čovjek) Bend 7p14.1 Početak 38,257,879 bp Kraj 38,265,678 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ortolozi
Vrste	Čovjek	Miš
Entrez	445347	n/a
Ensembl	ENSG00000211689	n/a
UniProt	Q0VGM3	n/a
RefSeq (mRNK)	NM_001003799 NM_001003806	n/a
RefSeq (bjelančevina)	NP_001003806.1	n/a
Lokacija (UCSC)	Chr 7: 38.26 – 38.27 Mb	n/a
PubMed pretraga		n/a
Wikipodaci
Pogledaj/uredi – čovjek

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 111 aminokiselina, а molekulska težina 12.847 Da.

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MKTNDTYMKF		SWLTVPEKSL		DKEHRCIVRH		ENNKNGVDQE		IIFPPIKTDV
ITMDPKDNCS		KDANDTLLLQ		LTNTSAYYMY		LLLLLKSVVY		FAIITCCLLR
RTAFCCNGEK		S

Funkcija

U nekim nelimfoidnim tkivima, eksprimiren je needitirani receptor T-ćelija gama (TRG@). Rezultirajući transkript sadrži podskup segmenata gena TRG@ i kraći je od transkripata TRG@ eksprimiranih u limfoidnim tkivima.

Ovaj RefSeq zapis predstavlja neuređen transkript lokusa TRG@; kompletan TRG@ lokus predstavljen je genomskim RefSeq NG_001336. Transkript predstavljen ovim RefSeqom ima dva otvorena okvira čitanja (ORF) koji kodiraju različite proteine. Nizvodni ORF nalazi se u istom okviru kao i TRG@, a njegov proteinski proizvod sličan je TRG@ proteinima. Uzvodni ORF koristi drugačiji okvir čitanja i kodira novi protein.

Dopunska literatura

• Yoshikai Y, Toyonaga B, Koga Y, et al. (1987). "Repertoire of the human T cell gamma genes: high frequency of nonfunctional transcripts in thymus and mature T cells". Eur. J. Immunol. 17 (1): 119–26. doi:10.1002/eji.1830170120. PMID 2949984. S2CID 43458672.
• Krangel MS, Band H, Hata S, et al. (1987). "Structurally divergent human T cell receptor gamma proteins encoded by distinct C gamma genes". Science. 237 (4810): 64–7. Bibcode:1987Sci...237...64K. doi:10.1126/science.2955517. PMID 2955517.
• Tighe L, Forster A, Clark DM, et al. (1988). "Unusual forms of T cell gamma mRNA in a human T cell leukemia cell line: implications for gamma gene expression". Eur. J. Immunol. 17 (12): 1729–36. doi:10.1002/eji.1830171208. PMID 2961573. S2CID 84409741.
• Littman DR, Newton M, Crommie D, et al. (1987). "Characterization of an expressed CD3-associated Ti gamma-chain reveals C gamma domain polymorphism". Nature. 326 (6108): 85–8. Bibcode:1987Natur.326...85L. doi:10.1038/326085a0. PMID 3102973. S2CID 4260305.
• Pelicci PG, Subar M, Weiss A, et al. (1987). "Molecular diversity of the human T-gamma constant region genes". Science. 237 (4818): 1051–5. Bibcode:1987Sci...237.1051P. doi:10.1126/science.3112943. PMID 3112943.
• Essand M, Vasmatzis G, Brinkmann U, et al. (1999). "High expression of a specific T-cell receptor gamma transcript in epithelial cells of the prostate". Proc. Natl. Acad. Sci. U.S.A. 96 (16): 9287–92. Bibcode:1999PNAS...96.9287E. doi:10.1073/pnas.96.16.9287. PMC 17772. PMID 10430935.
• Wolfgang CD, Essand M, Vincent JJ, et al. (2000). "TARP: a nuclear protein expressed in prostate and breast cancer cells derived from an alternate reading frame of the T cell receptor gamma chain locus". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9437–42. Bibcode:2000PNAS...97.9437W. doi:10.1073/pnas.160270597. PMC 16882. PMID 10931945.
• Wolfgang CD, Essand M, Lee B, Pastan I (2001). "T-cell receptor gamma chain alternate reading frame protein (TARP) expression in prostate cancer cells leads to an increased growth rate and induction of caveolins and amphiregulin". Cancer Res. 61 (22): 8122–6. PMID 11719440.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Cheng WS, Giandomenico V, Pastan I, Essand M (2003). "Characterization of the androgen-regulated prostate-specific T cell receptor gamma-chain alternate reading frame protein (TARP) promoter". Endocrinology. 144 (8): 3433–40. doi:10.1210/en.2003-0121. PMID 12865322.
• Maeda H, Nagata S, Wolfgang CD, et al. (2004). "The T cell receptor gamma chain alternate reading frame protein (TARP), a prostate-specific protein localized in mitochondria". J. Biol. Chem. 279 (23): 24561–8. doi:10.1074/jbc.M402492200. PMID 15150260.