SULT4A1
Sulfotransferaza 4A1 jest enzim koji je kod ljudi kodiran genom SULT4A1 sa hromosoma 22.[5][6]
Aminokiselinska sekvenca
urediDužina polipeptidnog lanca je 284 aminokiseline, a molekulska težina 33.085 Da.[6]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MAESEAETPS | TPGEFESKYF | EFHGVRLPPF | CRGKMEEIAN | FPVRPSDVWI | ||||
| VTYPKSGTSL | LQEVVYLVSQ | GADPDEIGLM | NIDEQLPVLE | YPQPGLDIIK | ||||
| ELTSPRLIKS | HLPYRFLPSD | LHNGDSKVIY | MARNPKDLVV | SYYQFHRSLR | ||||
| TMSYRGTFQE | FCRRFMNDKL | GYGSWFEHVQ | EFWEHRMDSN | VLFLKYEDMH | ||||
| RDLVTMVEQL | ARFLGVSCDK | AQLEALTEHC | HQLVDQCCNA | EALPVGRGRV | ||||
| GLWKDIFTVS | MNEKFDLVYK | QKMGKCDLTF | DFYL |
Funkcija
urediOvaj gen kodira člana porodice sulfotransferaza. Kodirani protein je sulfotransferaza specifična za mozak za koju se vjeruje da je uključena u metabolizam neurotransmitera. Polimorfizmi u ovom genu mogu biti povezani sa osjetljivošću na shizofreniju.[6]
Reference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000130540 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018865 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Falany CN, Xie X, Wang J, Ferrer J, Falany JL (May 2000). "Molecular cloning and expression of novel sulphotransferase-like cDNAs from human and rat brain". Biochem J. 346. Pt 3 (3): 857–64. doi:10.1042/bj3460857. PMC 1220923. PMID 10698717.
- ^ a b c "Entrez Gene: SULT4A1 sulfotransferase family 4A, member 1".
Dopunska literatura
uredi- Weinshilboum RM, Otterness DM, Aksoy IA, et al. (1997). "Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes". FASEB J. 11 (1): 3–14. doi:10.1096/fasebj.11.1.9034160. PMID 9034160. S2CID 3977677.
- Glatt H, Engelke CE, Pabel U, et al. (2000). "Sulfotransferases: genetics and role in toxicology". Toxicol. Lett. 112–113 (1–3): 341–8. doi:10.1016/S0378-4274(99)00214-3. PMID 10720750.
- Glatt H (2001). "Sulfotransferases in the bioactivation of xenobiotics". Chem. Biol. Interact. 129 (1–2): 141–70. doi:10.1016/S0009-2797(00)00202-7. PMID 11154739.
- Glatt H, Boeing H, Engelke CE, et al. (2001). "Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects". Mutat. Res. 482 (1–2): 27–40. doi:10.1016/S0027-5107(01)00207-X. PMID 11535246.
- Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
- Sakakibara Y, Suiko M, Pai TG, et al. (2002). "Highly conserved mouse and human brain sulfotransferases: molecular cloning, expression, and functional characterization". Gene. 285 (1–2): 39–47. doi:10.1016/S0378-1119(02)00431-6. PMID 12039030.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Collins JE, Goward ME, Cole CG, et al. (2003). "Reevaluating human gene annotation: a second-generation analysis of chromosome 22". Genome Res. 13 (1): 27–36. doi:10.1101/gr.695703. PMC 430954. PMID 12529303.
- Liyou NE, Buller KM, Tresillian MJ, et al. (2004). "Localization of a brain sulfotransferase, SULT4A1, in the human and rat brain: an immunohistochemical study". J. Histochem. Cytochem. 51 (12): 1655–64. doi:10.1177/002215540305101209. PMID 14623933.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Brennan MD, Condra J (2006). "Transmission disequilibrium suggests a role for the sulfotransferase-4A1 gene in schizophrenia". Am. J. Med. Genet. B Neuropsychiatr. Genet. 139 (1): 69–72. doi:10.1002/ajmg.b.30222. PMID 16152568. S2CID 8927459.
- Allali-Hassani A, Pan PW, Dombrovski L, et al. (2007). "Structural and chemical profiling of the human cytosolic sulfotransferases". PLOS Biol. 5 (5): e97. doi:10.1371/journal.pbio.0050097. PMC 1847840. PMID 17425406.