STEAP4

Član 4 porodice STEAP jest protein koji je kod ljudi kodiran genom STEAP4.

STEAP4
Identifikatori
Aliasi	STEAP4
Vanjski ID-jevi	OMIM: 611098 MGI: 1923560 HomoloGene: 36422 GeneCards: STEAP4
Lokacija gena (čovjek) Hrom. Hromosom 7 (čovjek) Bend 7q21.12 Početak 88,270,892 bp Kraj 88,306,894 bp
Lokacija gena (miš) Hrom. Hromosom 5 (miš) Bend 5|5 A1 Početak 8,010,457 bp Kraj 8,032,213 bp
Ontologija gena Molekularna funkcija • oxidoreductase activity • ferric-chelate reductase (NADPH) activity • vezivanje iona metala • cupric reductase activity • electron transfer activity • heme binding • FAD binding Ćelijska komponenta • integral component of membrane • Golđijeva membrana • ćelijska membrana • Egzosom • membrana • endozom • integral component of plasma membrane • Golđijev aparat • early endosome membrane Biološki proces • iron ion homeostasis • copper ion import • ion transport • fat cell differentiation • iron ion import across cell outer membrane • GO:0015915 transport • Lanac transporta elektrona • protein homotrimerization Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	79689	117167
Ensembl	ENSG00000127954	ENSMUSG00000012428
UniProt	Q687X5	Q923B6
RefSeq (mRNK)	NM_024636 NM_001205315 NM_001205316	NM_054098
RefSeq (bjelančevina)	NP_001192244 NP_001192245 NP_078912	NP_473439
Lokacija (UCSC)	Chr 7: 88.27 – 88.31 Mb	Chr 5: 8.01 – 8.03 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 459 aminokiselina, а molekulska težina 51.981 Da..

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MEKTCIDALP		LTMNSSEKQE		TVCIFGTGDF		GRSLGLKMLQ		CGYSVVFGSR
NPQKTTLLPS		GAEVLSYSEA		AKKSGIIIIA		IHREHYDFLT		ELTEVLNGKI
LVDISNNLKI		NQYPESNAEY		LAHLVPGAHV		VKAFNTISAW		ALQSGALDAS
RQVFVCGNDS		KAKQRVMDIV		RNLGLTPMDQ		GSLMAAKEIE		KYPLQLFPMW
RFPFYLSAVL		CVFLFFYCVI		RDVIYPYVYE		KKDNTFRMAI		SIPNRIFPIT
ALTLLALVYL		PGVIAAILQL		YRGTKYRRFP		DWLDHWMLCR		KQLGLVALGF
AFLHVLYTLV		IPIRYYVRWR		LGNLTVTQAI		LKKENPFSTS		SAWLSDSYVA
LGILGFFLFV		LLGITSLPSV		SNAVNWREFR		FVQSKLGYLT		LILCTAHTLV
YGGKRFLSPS		NLRWYLPAAY		VLGLIIPCTV		LVIKFVLIMP		CVDNTLTRIR
QGWERNSKH

Funkcija

Protein kodiran ovim genom pripada porodici STEAP (eng. skr. od šestotransmembranski epitelni antigen prostate), a nalazi se u Golgijevom aparatu. Funkcionira kao metaloreduktaza koja ima sposobnost redukcije i Fe (3+) na Fe (2+) i Cu (2+) na Cu (1+), koristeći NAD (+) kao akceptor. Studije na miševima i ljudima ukazuju da ovaj gen može biti uključen u razvoj adipocita i metabolizam, te može pridonijeti normalnoj biologiji ćelija prostate, kao i progresiji kancera. Za ovaj gen pronađene su alternativno prerađene varijante transkripta koje kodiraju različite izoforme.

Dopunska literatura

• Zhang CM, Chi X, Wang B, Zhang M, Ni YH, Chen RH, Li XN, Guo XR (maj 2008). "Downregulation of STEAP4, a highly-expressed TNF-alpha-inducible gene in adipose tissue, is associated with obesity in humans". Acta Pharmacologica Sinica. 29 (5): 587–92. doi:10.1111/j.1745-7254.2008.00793.x. PMID 18430367. S2CID 20248700.
• Bi YW, Wang CM, Yan ZT, Li NF, Guo YY, Wang HM, Yao XG, Liang DP (februar 2011). "[Negative association of STAMP2 gene polymorphisms with essential hypertension in Xinjiang Uygur population]". Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics. 28 (1): 64–8. doi:10.3760/cma.j.issn.1003-9406.2011.01.015. PMID 21287513.
• Kralisch S, Sommer G, Weise S, Lipfert J, Lossner U, Kamprad M, Schröck K, Bluher M, Stumvoll M, Fasshauer M (april 2009). "Interleukin-1beta is a positive regulator of TIARP/STAMP2 gene and protein expression in adipocytes in vitro". FEBS Letters. 583 (7): 1196–200. doi:10.1016/j.febslet.2009.03.015. PMID 19289123. S2CID 31106264.
• Guo YY, Li NF, Wang CM, Yan ZT, Zhang JH, Wang HM, Zhou L, Luo WL (februar 2011). "[Genetic variation and association of STEAP4 gene with metabolic syndrome in Chinese Uygur patients]". Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics. 28 (1): 78–82. doi:10.3760/cma.j.issn.1003-9406.2011.01.018. PMID 21287516.
• Nanfang L, Yanying G, Hongmei W, Zhitao Y, Juhong Z, Ling Z, Wenli L (august 2010). "Variations of six transmembrane epithelial antigen of prostate 4 (STEAP4) gene are associated with metabolic syndrome in a female Uygur general population". Archives of Medical Research. 41 (6): 449–56. doi:10.1016/j.arcmed.2010.08.006. PMID 21044749.
• Tanaka Y, Matsumoto I, Iwanami K, Inoue A, Minami R, Umeda N, Kanamori A, Ochiai N, Miyazawa K, Sugihara M, Hayashi T, Goto D, Ito S, Sumida T (februar 2012). "Six-transmembrane epithelial antigen of prostate4 (STEAP4) is a tumor necrosis factor alpha-induced protein that regulates IL-6, IL-8, and cell proliferation in synovium from patients with rheumatoid arthritis". Modern Rheumatology. 22 (1): 128–36. doi:10.1007/s10165-011-0475-y. PMID 21633911. S2CID 21108512.
• Guo YY, Li NF, Zhou L, Yao XG, Wang HM, Zhang JH, Luo WL (juli 2011). "A common variation within the STEAP4 gene exons is associated with obesity in Uygur general population". Chinese Medical Journal. 124 (14): 2096–100. PMID 21933608.
• Wangensteen T, Akselsen H, Holmen J, Undlien D, Retterstøl L (mart 2011). "A common haplotype in NAPEPLD is associated with severe obesity in a Norwegian population-based cohort (the HUNT study)". Obesity. 19 (3): 612–7. doi:10.1038/oby.2010.219. PMID 20885390. S2CID 205528202.
• Korkmaz CG, Korkmaz KS, Kurys P, Elbi C, Wang L, Klokk TI, Hammarstrom C, Troen G, Svindland A, Hager GL, Saatcioglu F (juli 2005). "Molecular cloning and characterization of STAMP2, an androgen-regulated six transmembrane protein that is overexpressed in prostate cancer". Oncogene. 24 (31): 4934–45. doi:10.1038/sj.onc.1208677. PMID 15897894. S2CID 22999842.