STAMBPL1

STAMBPL1
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2ZNR, 2ZNV
Identifikatori
Aliasi	STAMBPL1
Vanjski ID-jevi	OMIM: 612352 MGI: 1923880 HomoloGene: 23253 GeneCards: STAMBPL1
Lokacija gena (čovjek)
Hrom.	Hromosom 10 (čovjek)
Kraj	88,975,153 bp
Lokacija gena (miš)
Hrom.	Hromosom 19 (miš)
Kraj	34,217,733 bp
Ontologija gena
Molekularna funkcija	• GO:0070122 peptidase activity; • GO:0001948, GO:0016582 vezivanje za proteine; • hydrolase activity; • metallopeptidase activity; • vezivanje iona metala; • Lys63-specific deubiquitinase activity; • thiol-dependent deubiquitinase;
Ćelijska komponenta	• membrana; • citosol; • endozom;
Biološki proces	• Proteoliza; • protein deubiquitination; • protein K63-linked deubiquitination;
	Izvori:Amigo / QuickGO
Ortolozi
	57559
	76630
	ENSG00000138134
	ENSMUSG00000024776
	Q96FJ0
	Q76N33
	NM_020799
NM_029682; NM_001360716; NM_001360717; NM_001360718; NM_001360719;
	NM_001360720
	NP_065850
NP_083958; NP_001347645; NP_001347646; NP_001347647; NP_001347648;
	NP_001347649
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

AMSH-olika proteaza je enzim koji je kod ljudi kodiran genom STAMBPL1.^[5]^[6]^[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 436 aminokiselina, а molekulska težina 49.783 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MDQPFTVNSL	KKLAAMPDHT	DVSLSPEERV	RALSKLGCNI	TISEDITPRR
YFRSGVEMER	MASVYLEEGN	LENAFVLYNK	FITLFVEKLP	NHRDYQQCAV
PEKQDIMKKL	KEIAFPRTDE	LKNDLLKKYN	VEYQEYLQSK	NKYKAEILKK
LEHQRLIEAE	RKRIAQMRQQ	QLESEQFLFF	EDQLKKQELA	RGQMRSQQTS
GLSEQIDGSA	LSCFSTHQNN	SLLNVFADQP	NKSDATNYAS	HSPPVNRALT
PAATLSAVQN	LVVEGLRCVV	LPEDLCHKFL	QLAESNTVRG	IETCGILCGK
LTHNEFTITH	VIVPKQSAGP	DYCDMENVEE	LFNVQDQHDL	LTLGWIHTHP
TQTAFLSSVD	LHTHCSYQLM	LPEAIAIVCS	PKHKDTGIFR	LTNAGMLEVS
ACKKKGFHPH	TKEPRLFSIC	KHVLVKDIKI	IVLDLR

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138134 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024776 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kikuchi K, Ishii N, Asao H, Sugamura K (Jun 2003). "Identification of AMSH-LP containing a Jab1/MPN domain metalloenzyme motif". Biochem Biophys Res Commun. 306 (3): 637–43. doi:10.1016/S0006-291X(03)01009-X. PMID 12810066.
^ Kitajima K, Matsumoto K, Tahara M, Takahashi H, Nakamura T, Nakamura T (Aug 2003). "A newly identified AMSH-family protein is specifically expressed in haploid stages of testicular germ cells". Biochem Biophys Res Commun. 309 (1): 135–42. doi:10.1016/S0006-291X(03)01550-X. PMID 12943674.
^ "Entrez Gene: STAMBPL1 STAM binding protein-like 1".
^ "UniProt, Q96FJ0". Pristupljeno 5. 9. 2021.

Dopunska literatura

Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Ibarrola N, Kratchmarova I, Nakajima D, et al. (2004). "Cloning of a novel signaling molecule, AMSH-2, that potentiates transforming growth factor beta signaling". BMC Cell Biol. 5: 2. doi:10.1186/1471-2121-5-2. PMC 385422. PMID 14728725.
Li H, Seth A (2004). "An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein". Oncogene. 23 (10): 1801–8. doi:10.1038/sj.onc.1207319. PMID 14755250.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Nakamura M, Tanaka N, Kitamura N, Komada M (2006). "Clathrin anchors deubiquitinating enzymes, AMSH and AMSH-like protein, on early endosomes". Genes Cells. 11 (6): 593–606. doi:10.1111/j.1365-2443.2006.00963.x. PMID 16716190. S2CID 30077507.
Reyes-Ibarra AP, García-Regalado A, Ramírez-Rangel I, et al. (2007). "Calcium-sensing receptor endocytosis links extracellular calcium signaling to parathyroid hormone-related peptide secretion via a Rab11a-dependent and AMSH-sensitive mechanism". Mol. Endocrinol. 21 (6): 1394–407. doi:10.1210/me.2006-0523. PMID 17426287.

Vanjski linkovi

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138134 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024776 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12810066-5] Kikuchi K, Ishii N, Asao H, Sugamura K (Jun 2003). "Identification of AMSH-LP containing a Jab1/MPN domain metalloenzyme motif". Biochem Biophys Res Commun. 306 (3): 637–43. doi:10.1016/S0006-291X(03)01009-X. PMID 12810066.

[pmid12943674-6] Kitajima K, Matsumoto K, Tahara M, Takahashi H, Nakamura T, Nakamura T (Aug 2003). "A newly identified AMSH-family protein is specifically expressed in haploid stages of testicular germ cells". Biochem Biophys Res Commun. 309 (1): 135–42. doi:10.1016/S0006-291X(03)01550-X. PMID 12943674.

[entrez-7] "Entrez Gene: STAMBPL1 STAM binding protein-like 1".

[UniProt-8] "UniProt, Q96FJ0". Pristupljeno 5. 9. 2021.

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