SSB
Tip B antigena Sjögrenovog sindroma (SS-B) znan i kao lupusni La protein jest protein koji je kod ljudi kodiran genom SSB sa hromosoma 2.[5]
Amiokiselininska sekvenca
urediDužina polipeptidnog lanca je 408 aminokiselina, a molekulska težina 46.837 Da.[6]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MAENGDNEKM | AALEAKICHQ | IEYYFGDFNL | PRDKFLKEQI | KLDEGWVPLE | ||||
| IMIKFNRLNR | LTTDFNVIVE | ALSKSKAELM | EISEDKTKIR | RSPSKPLPEV | ||||
| TDEYKNDVKN | RSVYIKGFPT | DATLDDIKEW | LEDKGQVLNI | QMRRTLHKAF | ||||
| KGSIFVVFDS | IESAKKFVET | PGQKYKETDL | LILFKDDYFA | KKNEERKQNK | ||||
| VEAKLRAKQE | QEAKQKLEED | AEMKSLEEKI | GCLLKFSGDL | DDQTCREDLH | ||||
| ILFSNHGEIK | WIDFVRGAKE | GIILFKEKAK | EALGKAKDAN | NGNLQLRNKE | ||||
| VTWEVLEGEV | EKEALKKIIE | DQQESLNKWK | SKGRRFKGKG | KGNKAAQPGS | ||||
| GKGKVQFQGK | KTKFASDDEH | DEHDENGATG | PVKRAREETD | KEEPASKQQK | ||||
| TENGAGDQ |
Funkcija
urediLa je uključen u različite aspekte metabolizma RNK, uključujući vezivanje i zaštitu 3-prim UUU (OH) elemenata nove RNK-polimeraze III-transkribirane RNK, prerađivanje 5' i 3' krajeva prekursora pre-tRNK, djeluje kao RNK šaperon i vezuje virusne RNK, povezane s virusom hepatitisa C. La protein je prvobitno definiran njegovom reaktivnošću sa autoantitelima pacijenata sa Sjögrenovim sindromom i sistemskim eritemskim lupusom.[5][7]
Interakcije
urediPokazalo se da antigen B Sjogrenovog sindroma ima reakcije sa nukleolinom.[8]
Također pogledajte
urediReference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000138385 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000068882 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: SSB Sjögren's syndrome antigen B (autoantigen La)".
- ^ "UniProt, P05455" (jezik: engleski). Pristupljeno 19. 11. 2021.
- ^ Teplova M, Yuan YR, Phan AT, Malinina L, Ilin S, Teplov A, Patel DJ (januar 2006). "Structural basis for recognition and sequestration of UUU(OH) 3' temini of nascent RNA polymerase III transcripts by La, a rheumatic disease autoantigen". Molecular Cell. 21 (1): 75–85. doi:10.1016/j.molcel.2005.10.027. PMC 4689297. PMID 16387655.
- ^ Fouraux MA, Bouvet P, Verkaart S, van Venrooij WJ, Pruijn GJ (juli 2002). "Nucleolin associates with a subset of the human Ro ribonucleoprotein complexes". Journal of Molecular Biology. 320 (3): 475–88. doi:10.1016/S0022-2836(02)00518-1. PMID 12096904.
Dopunska literatura
uredi- Kohsaka H, Yamamoto K, Fujii H, Miura H, Miyasaka N, Nishioka K, Miyamoto T (maj 1990). "Fine epitope mapping of the human SS-B/La protein. Identification of a distinct autoepitope homologous to a viral gag polyprotein". The Journal of Clinical Investigation. 85 (5): 1566–74. doi:10.1172/JCI114606. PMC 296607. PMID 1692037.
- Sturgess AD, Peterson MG, McNeilage LJ, Whittingham S, Coppel RL (maj 1988). "Characteristics and epitope mapping of a cloned human autoantigen La". Journal of Immunology. 140 (9): 3212–8. PMID 2452201.
- Rauh AJ, Hornig H, Lührmann R (decembar 1988). "At least three distinct B cell epitopes reside in the C-terminal half of La protein, as determined by a recombinant DNA approach". European Journal of Immunology. 18 (12): 2049–57. doi:10.1002/eji.1830181227. PMID 2464497. S2CID 7014818.
- Chan EK, Sullivan KF, Tan EM (mart 1989). "Ribonucleoprotein SS-B/La belongs to a protein family with consensus sequences for RNA-binding". Nucleic Acids Research. 17 (6): 2233–44. doi:10.1093/nar/17.6.2233. PMC 317593. PMID 2468131.
- Gottlieb E, Steitz JA (mart 1989). "Function of the mammalian La protein: evidence for its action in transcription termination by RNA polymerase III". The EMBO Journal. 8 (3): 851–61. doi:10.1002/j.1460-2075.1989.tb03446.x. PMC 400884. PMID 2470590.
- Chambers JC, Kenan D, Martin BJ, Keene JD (decembar 1988). "Genomic structure and amino acid sequence domains of the human La autoantigen". The Journal of Biological Chemistry. 263 (34): 18043–51. doi:10.1016/S0021-9258(19)81321-2. PMID 3192525.
- Chambers JC, Keene JD (april 1985). "Isolation and analysis of cDNA clones expressing human lupus La antigen". Proceedings of the National Academy of Sciences of the United States of America. 82 (7): 2115–9. Bibcode:1985PNAS...82.2115C. doi:10.1073/pnas.82.7.2115. PMC 397503. PMID 3856888.
- Svitkin YV, Pause A, Sonenberg N (novembar 1994). "La autoantigen alleviates translational repression by the 5' leader sequence of the human immunodeficiency virus type 1 mRNA". Journal of Virology. 68 (11): 7001–7. doi:10.1128/jvi.68.11.7001-7007.1994. PMC 237137. PMID 7933082.
- Tröster H, Metzger TE, Semsei I, Schwemmle M, Winterpacht A, Zabel B, Bachmann M (decembar 1994). "One gene, two transcripts: isolation of an alternative transcript encoding for the autoantigen La/SS-B from a cDNA library of a patient with primary Sjögrens' syndrome". The Journal of Experimental Medicine. 180 (6): 2059–67. doi:10.1084/jem.180.6.2059. PMC 2191769. PMID 7964483.
- Fan H, Sakulich AL, Goodier JL, Zhang X, Qin J, Maraia RJ (mart 1997). "Phosphorylation of the human La antigen on serine 366 can regulate recycling of RNA polymerase III transcription complexes". Cell. 88 (5): 707–15. doi:10.1016/S0092-8674(00)81913-3. PMID 9054510. S2CID 2223069.
- McLaren RS, Caruccio N, Ross J (juni 1997). "Human La protein: a stabilizer of histone mRNA". Molecular and Cellular Biology. 17 (6): 3028–36. doi:10.1128/mcb.17.6.3028. PMC 232155. PMID 9154801.
- Grölz D, Bachmann M (april 1997). "The nuclear autoantigen La/SS-associated antigen B: one gene, three functional mRNAs". The Biochemical Journal. 323 ( Pt 1) (1): 151–8. doi:10.1042/bj3230151. PMC 1218288. PMID 9173875.
- Helsloot J, Sturgess A (decembar 1997). "T cell reactivity to Sjögren's syndrome related antigen La(SSB)". The Journal of Rheumatology. 24 (12): 2340–7. PMID 9415639.
- Broekhuis CH, Neubauer G, van der Heijden A, Mann M, Proud CG, van Venrooij WJ, Pruijn GJ (mart 2000). "Detailed analysis of the phosphorylation of the human La (SS-B) autoantigen. (De)phosphorylation does not affect its subcellular distribution". Biochemistry. 39 (11): 3023–33. doi:10.1021/bi992308c. PMID 10715123.
- Spångberg K, Wiklund L, Schwartz S (septembar 2000). "HuR, a protein implicated in oncogene and growth factor mRNA decay, binds to the 3' ends of hepatitis C virus RNA of both polarities". Virology. 274 (2): 378–90. doi:10.1006/viro.2000.0461. PMID 10964780.
- Intine RV, Sakulich AL, Koduru SB, Huang Y, Pierstorff E, Goodier JL, Phan L, Maraia RJ (august 2000). "Control of transfer RNA maturation by phosphorylation of the human La antigen on serine 366". Molecular Cell. 6 (2): 339–48. doi:10.1016/S1097-2765(00)00034-4. PMID 10983981.
- Nashimoto M, Nashimoto C, Tamura M, Kaspar RL, Ochi K (oktobar 2001). "The inhibitory effect of the autoantigen La on in vitro 3' processing of mammalian precursor tRNAs". Journal of Molecular Biology. 312 (5): 975–84. doi:10.1006/jmbi.2001.5026. PMID 11580243.
- De Nova-Ocampo M, Villegas-Sepúlveda N, del Angel RM (april 2002). "Translation elongation factor-1alpha, La, and PTB interact with the 3' untranslated region of dengue 4 virus RNA". Virology. 295 (2): 337–47. doi:10.1006/viro.2002.1407. PMID 12033793.
- Intine RV, Dundr M, Misteli T, Maraia RJ (maj 2002). "Aberrant nuclear trafficking of La protein leads to disordered processing of associated precursor tRNAs". Molecular Cell. 9 (5): 1113–23. doi:10.1016/S1097-2765(02)00533-6. PMID 12049746.
- Fouraux MA, Bouvet P, Verkaart S, van Venrooij WJ, Pruijn GJ (juli 2002). "Nucleolin associates with a subset of the human Ro ribonucleoprotein complexes". Journal of Molecular Biology. 320 (3): 475–88. doi:10.1016/S0022-2836(02)00518-1. PMID 12096904.