SPAG11B

SPAG11B
Identifikatori
Aliasi	SPAG11B
Vanjski ID-jevi	OMIM: 606560 MGI: 3647173 HomoloGene: 83383 GeneCards: SPAG11B
Lokacija gena (čovjek)
Hrom.	Hromosom 8 (čovjek)
Kraj	7,463,674 bp
Lokacija gena (miš)
Hrom.	Hromosom 8 (miš)
Kraj	19,193,026 bp
Ontologija gena
Molekularna funkcija	• molekularna funkcija;
Ćelijska komponenta	• extracellular region;
Biološki proces	• Spermatogeneza; • antimicrobial humoral immune response mediated by antimicrobial peptide; • defense response; • defense response to bacterium;
	Izvori:Amigo / QuickGO
Ortolozi
	10407
	546038
	ENSG00000164871; ENSG00000274405; ENSG00000288309
	ENSMUSG00000059463
	Q08648; Q6PDA7
	Q8K4N2; Q3UW43
NM_016512; NM_058200; NM_058201; NM_058202; NM_058203;
	NM_058206; NM_058207
	NM_001034905; NM_001039563; NM_001286493
NP_057596; NP_478107; NP_478108; NP_478109; NP_478110;
	NP_478113; NP_478114; NP_001075021; NP_001350655; NP_001075021; NP_001350655
	NP_694755; NP_001030077; NP_001034652; NP_001273422
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Spermopridruženi antigen 11B je protein koji je kod ljudi kodiran genom SPAG11B.^[5]^[6]^[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 103 aminokiseline, а molekulska težina 11.431 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MRQRLLPSVT	SLLLVALLFP	GSSQARHVNH	SATEALGELR	ERAPGQGTNG
FQLLRHAVKR	DLLPPRTPPY	QVHISHREAR	GPSFRICVDF	LGPRWARGCS
TGN

Funkcija

Ovaj gen kodira nekoliko androgeno zavisnih, epididimisno specifičnih sekretornih proteina. Specifične funkcije ovih proteina nisu utvrđene, ali se smatra da su uključene u sazrijevanje spermatozoida. Neke od izoformi sadrže regije slične beta-defenzinima, porodice antimikrobnih peptida. Gen se nalazi na hromosomu 8, sekvenca p23, u blizini klastera gena za defenzin. Alternativna prerada ovog gena rezultira sa sedam varijanti transkripta koje kodiraju različite izoforme. Dvije različite N-terminalne i pet različitih C-terminalnih proteinskih sekvenci kodirane su prerađenim varijantama. Opisane su dvije dodatne varijante, ali njihove pune sekvence nisu utvrđene.^[7]

Reference

^ ^a ^b ^c ENSG00000274405, ENSG00000288309 GRCh38: Ensembl release 89: ENSG00000164871, ENSG00000274405, ENSG00000288309 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000059463 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Osterhoff C, Kirchhoff C, Krull N, Ivell R (mart 1994). "Molecular cloning and characterization of a novel human sperm antigen (HE2) specifically expressed in the proximal epididymis". Biology of Reproduction. 50 (3): 516–25. doi:10.1095/biolreprod50.3.516. PMID 8167223.
^ Kirchhoff C, Osterhoff C, Habben I, Ivell R, Kirchloff C (april 1990). "Cloning and analysis of mRNAs expressed specifically in the human epididymis". International Journal of Andrology. 13 (2): 155–67. doi:10.1111/j.1365-2605.1990.tb00972.x. PMID 1693137.
^ ^a ^b "Entrez Gene: SPAG11 sperm associated antigen 11".
^ "UniProt, Q08648" (jezik: engleski). Pristupljeno 21. 9. 2021.

Dopunska literatura

Krull N, Ivell R, Osterhoff C, Kirchhoff C (januar 1993). "Region-specific variation of gene expression in the human epididymis as revealed by in situ hybridization with tissue-specific cDNAs". Molecular Reproduction and Development. 34 (1): 16–24. doi:10.1002/mrd.1080340104. PMID 8418812. S2CID 24008790.
Hamil KG, Sivashanmugam P, Richardson RT, Grossman G, Ruben SM, Mohler JL, Petrusz P, O'Rand MG, French FS, Hall SH (mart 2000). "HE2beta and HE2gamma, new members of an epididymis-specific family of androgen-regulated proteins in the human". Endocrinology. 141 (3): 1245–53. doi:10.1210/en.141.3.1245. PMID 10698202.
Fröhlich O, Po C, Murphy T, Young LG (2000). "Multiple promoter and splicing mRNA variants of the epididymis-specific gene EP2". Journal of Andrology. 21 (3): 421–30. PMID 10819450.
Fröhlich O, Po C, Young LG (april 2001). "Organization of the human gene encoding the epididymis-specific EP2 protein variants and its relationship to defensin genes". Biology of Reproduction. 64 (4): 1072–9. doi:10.1095/biolreprod64.4.1072. PMID 11259252.
von Horsten HH, Derr P, Kirchhoff C (septembar 2002). "Novel antimicrobial peptide of human epididymal duct origin". Biology of Reproduction. 67 (3): 804–13. doi:10.1095/biolreprod.102.004564. PMID 12193388.
Légaré C, Verville N, Sullivan R (2004). "Vasectomy influences expression of HE1 but not HE2 and HE5 genes in human epididymis". Journal of Andrology. 25 (1): 30–43. doi:10.1002/j.1939-4640.2004.tb02756.x. PMID 14662784.
Avellar MC, Honda L, Hamil KG, Yenugu S, Grossman G, Petrusz P, French FS, Hall SH (novembar 2004). "Differential expression and antibacterial activity of epididymis protein 2 isoforms in the male reproductive tract of human and rhesus monkey (Macaca mulatta)". Biology of Reproduction. 71 (5): 1453–60. doi:10.1095/biolreprod.104.031740. PMID 15229135.

[refGRCh38Ensembl-1] ENSG00000274405, ENSG00000288309 GRCh38: Ensembl release 89: ENSG00000164871, ENSG00000274405, ENSG00000288309 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000059463 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8167223-5] Osterhoff C, Kirchhoff C, Krull N, Ivell R (mart 1994). "Molecular cloning and characterization of a novel human sperm antigen (HE2) specifically expressed in the proximal epididymis". Biology of Reproduction. 50 (3): 516–25. doi:10.1095/biolreprod50.3.516. PMID 8167223.

[pmid1693137-6] Kirchhoff C, Osterhoff C, Habben I, Ivell R, Kirchloff C (april 1990). "Cloning and analysis of mRNAs expressed specifically in the human epididymis". International Journal of Andrology. 13 (2): 155–67. doi:10.1111/j.1365-2605.1990.tb00972.x. PMID 1693137.

[entrez-7] "Entrez Gene: SPAG11 sperm associated antigen 11".

[UniProt-8] "UniProt, Q08648" (jezik: engleski). Pristupljeno 21. 9. 2021.

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