SMCP

SMCP
Identifikatori
Aliasi	SMCP
Vanjski ID-jevi	OMIM: 601148 MGI: 96945 HomoloGene: 136205 GeneCards: SMCP
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	152,885,047 bp
Lokacija gena (miš)
Hrom.	Hromosom 3 (miš)
Kraj	92,496,304 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • molekularna funkcija;
Ćelijska komponenta	• citoplazma; • mitochondrial membranes; • mitohondrija; • membrana;
Biološki proces	• flagellated sperm motility; • penetration of zona pellucida; • single fertilization;
	Izvori:Amigo / QuickGO
Ortolozi
	4184
	17235
	ENSG00000163206
	ENSMUSG00000074435
	P49901
	P15265
	NM_030663
	NM_008574
	NP_109588
	NP_032600
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Šećerni transporter SWEET1, poznat i kao RAG1-aktivirajući protein 1 i protein ćelijske strome (SMSCP), jest membranski protein koji je kod ljudi kodiran genom SLC50A1 sa hromosoma 1.^[5] SWEET1 je jedini transporter iz porodice gena SLC50 (SWEET) prisutan u genomima većine životinjskih vrsta, sa izuzetkom nematode Caenorhabditis elegans, koja ima sedam^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 221 aminokiselina, a molekulska težina 25.030 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MEAGGFLDSL	IYGACVVFTL	GMFSAGLSDL	RHMRMTRSVD	NVQFLPFLTT
EVNNLGWLSY	GALKGDGILI	VVNTVGAALQ	TLYILAYLHY	CPRKRVVLLQ
TATLLGVLLL	GYGYFWLLVP	NPEARLQQLG	LFCSVFTISM	YLSPLADLAK
VIQTKSTQCL	SYPLTIATLL	TSASWCLYGF	RLRDPYIMVS	NFPGIVTSFI
RFWLFWKYPQ	EQDRNYWLLQ	T

Funkcija

SWEET1 je široko eksprimirann transporter glukoze.^[6] Kako je porodica SWEET identificirana relativno nedavno, cijeli spektar njenih funkcija kod životinja još nije jasan.^[8] Međutim, goveđi homolog SLC50A1 povezan je sa koncentracijom laktoze u mlijeku,^[9] a homolog CiRGA u morski om mlazu Ciona intestinalis neophodan je za diferencijaciju tkiva tokom embriogeneze, posebno za razvoj notohorda.^[10]

SWEET geni uobičajeni su u biljnim genomima, sa dvadesetak paraloga ^[6] koji funkcionišu i kao transporteri saharoze i heksoze, a također su povezani i sa osjetljivošću na patogene.^[6]^[11]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163206 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000074435 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Solute carrier family 50 (sugar efflux transporter), member 1".
^ ^a ^b ^c ^d Feng L, Frommer WB (2015). "Structure and function of SemiSWEET and SWEET sugar transporters". Trends in Biochemical Sciences. 40 (8): 480–486. doi:10.1016/j.tibs.2015.05.005. PMID 26071195.
^ "UniProt, Q9BRV3" (jezik: engleski). Pristupljeno 19. 12. 2021.
^ Deng D, Yan N (2016). "GLUT, SGLT, and SWEET: Structural and mechanistic investigations of the glucose transporters". Protein Science. 25 (3): 546–558. doi:10.1002/pro.2858. PMC 4815417. PMID 26650681.
^ Lopdell TJ, T iplady K, Struchalin M, Johnson TJ, Keehan M, Sherlock R, Couldrey C, Davis SR, Snell RG, Spelman RJ, Littlejohn MD (2017). "DNA and RNA-sequence based GWAS highlights membrane-transport genes as key modulators of milk lactose content". BMC Genomics. 18 (1): 968. doi:10.1186/s12864-017-4320-3. PMC 5731188. PMID 29246110. line feed character u |vauthors= na mjestu 14 (pomoć)
^ Hamada M, Wada S, Kobayashi K, Satoh N (2005). "Ci-Rga, a gene encoding an MtN3/saliva family transmembrane protein, is essential for tissue differentiation during embryogenesis of the ascidian Ciona intestinalis". Differentiation. 73 (7): 364–376. doi:10.1111/j.1432-0436.2005.00037.x. PMID 16219040.
^ Wright EM (2013). "Glucose transport families SLC5 and SLC50". Molecular Aspects of Medicine. 34 (2–3): 183–196. doi:10.1016/j.mam.2012.11.002. PMID 23506865.

Dopunska literatura

Barnhill JC, Stokes AJ, Koblan-Huberson M, Shimoda LM, Muraguchi A, Adra CN, Turner H (Mar 2004). "RGA protein associates with a TRPV ion channel during biosynthesis and trafficking". Journal of Cellular Biochemistry. 91 (4): 808–20. doi:10.1002/jcb.10775. PMID 14991772. S2CID 44629547.
Pankratz N, Beecham GW, DeStefano AL, Dawson TM, Doheny KF, Factor SA, Hamza TH, Hung AY, Hyman BT, Ivinson AJ, Krainc D, Latourelle JC, Clark LN, Marder K, Martin ER, Mayeux R, Ross OA, Scherzer CR, Simon DK, Tanner C, Vance JM, Wszolek ZK, Zabetian CP, Myers RH, Payami H, Scott WK, Foroud T (Mar 2012). "Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2". Annals of Neurology. 71 (3): 370–84. doi:10.1002/ana.22687. PMC 3354734. PMID 22451204.
Chen LQ, Hou BH, Lalonde S, Takanaga H, Hartung ML, Qu XQ, Guo WJ, Kim JG, Underwood W, Chaudhuri B, Chermak D, Antony G, White FF, Somerville SC, Mudgett MB, Frommer WB (Nov 2010). "Sugar transporters for intercellular exchange and nutrition of pathogens". Nature. 468 (7323): 527–32. Bibcode:2010Natur.468..527C. doi:10.1038/nature09606. PMC 3000469. PMID 21107422.
Tagoh H, Kishi H, Muraguchi A (Apr 1996). "Molecular cloning and characterization of a novel stromal cell-derived cDNA encoding a protein that facilitates gene activation of recombination activating gene (RAG)-1 in human lymphoid progenitors". Biochemical and Biophysical Research Communications. 221 (3): 744–9. doi:10.1006/bbrc.1996.0667. PMID 8630032.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163206 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000074435 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Solute carrier family 50 (sugar efflux transporter), member 1".

[pmid26071195-6] Feng L, Frommer WB (2015). "Structure and function of SemiSWEET and SWEET sugar transporters". Trends in Biochemical Sciences. 40 (8): 480–486. doi:10.1016/j.tibs.2015.05.005. PMID 26071195.

[UniProt-7] "UniProt, Q9BRV3" (jezik: engleski). Pristupljeno 19. 12. 2021.

[pmid26650681-8] Deng D, Yan N (2016). "GLUT, SGLT, and SWEET: Structural and mechanistic investigations of the glucose transporters". Protein Science. 25 (3): 546–558. doi:10.1002/pro.2858. PMC 4815417. PMID 26650681.

[pmid29246110-9] Lopdell TJ, T iplady K, Struchalin M, Johnson TJ, Keehan M, Sherlock R, Couldrey C, Davis SR, Snell RG, Spelman RJ, Littlejohn MD (2017). "DNA and RNA-sequence based GWAS highlights membrane-transport genes as key modulators of milk lactose content". BMC Genomics. 18 (1): 968. doi:10.1186/s12864-017-4320-3. PMC 5731188. PMID 29246110. line feed character u |vauthors= na mjestu 14 (pomoć)

[pmid16219040-10] Hamada M, Wada S, Kobayashi K, Satoh N (2005). "Ci-Rga, a gene encoding an MtN3/saliva family transmembrane protein, is essential for tissue differentiation during embryogenesis of the ascidian Ciona intestinalis". Differentiation. 73 (7): 364–376. doi:10.1111/j.1432-0436.2005.00037.x. PMID 16219040.

[pmid23506865-11] Wright EM (2013). "Glucose transport families SLC5 and SLC50". Molecular Aspects of Medicine. 34 (2–3): 183–196. doi:10.1016/j.mam.2012.11.002. PMID 23506865.

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