SGPL1
Sfingozin-1-fosfat lijaza 1 je enzim koji je kod ljudi kodiran genom SGPL1.[5][6][7]
Aminokiselinska sekvenca
urediDužina polipeptidnog lanca je 568 aminokiselina, а molekulska težina 63.524 Da.[8]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MPSTDLLMLK | AFEPYLEILE | VYSTKAKNYV | NGHCTKYEPW | QLIAWSVVWT | ||||
| LLIVWGYEFV | FQPESLWSRF | KKKCFKLTRK | MPIIGRKIQD | KLNKTKDDIS | ||||
| KNMSFLKVDK | EYVKALPSQG | LSSSAVLEKL | KEYSSMDAFW | QEGRASGTVY | ||||
| SGEEKLTELL | VKAYGDFAWS | NPLHPDIFPG | LRKIEAEIVR | IACSLFNGGP | ||||
| DSCGCVTSGG | TESILMACKA | YRDLAFEKGI | KTPEIVAPQS | AHAAFNKAAS | ||||
| YFGMKIVRVP | LTKMMEVDVR | AMRRAISRNT | AMLVCSTPQF | PHGVIDPVPE | ||||
| VAKLAVKYKI | PLHVDACLGG | FLIVFMEKAG | YPLEHPFDFR | VKGVTSISAD | ||||
| THKYGYAPKG | SSLVLYSDKK | YRNYQFFVDT | DWQGGIYASP | TIAGSRPGGI | ||||
| SAACWAALMH | FGENGYVEAT | KQIIKTARFL | KSELENIKGI | FVFGNPQLSV | ||||
| IALGSRDFDI | YRLSNLMTAK | GWNLNQLQFP | PSIHFCITLL | HARKRVAIQF | ||||
| LKDIRESVTQ | IMKNPKAKTT | GMGAIYGMAQ | TTVDRNMVAE | LSSVFLDSLY | ||||
| STDTVTQGSQ | MNGSPKPH |
Reference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000166224 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020097 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Zhou J, Saba JD (Mar 1998). "Identification of the first mammalian sphingosine phosphate lyase gene and its functional expression in yeast". Biochem Biophys Res Commun. 242 (3): 502–7. doi:10.1006/bbrc.1997.7993. PMID 9464245.
- ^ Oskouian B, Sooriyakumaran P, Borowsky AD, Crans A, Dillard-Telm L, Tam YY, Bandhuvula P, Saba JD (Nov 2006). "Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer". Proc Natl Acad Sci U S A. 103 (46): 17384–9. doi:10.1073/pnas.0600050103. PMC 1859938. PMID 17090686.
- ^ "Entrez Gene: SGPL1 sphingosine-1-phosphate lyase 1".
- ^ "UniProt, O95470". Pristupljeno 4. 9. 2021.
Dopunska literatuara
uredi- Van Veldhoven PP, Mannaerts GP (1991). "Subcellular localization and membrane topology of sphingosine-1-phosphate lyase in rat liver". J. Biol. Chem. 266 (19): 12502–7. PMID 2061324.
- Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
- Van Veldhoven PP, Gijsbers S, Mannaerts GP, et al. (2000). "Human sphingosine-1-phosphate lyase: cDNA cloning, functional expression studies and mapping to chromosome 10q22(1)". Biochim. Biophys. Acta. 1487 (2–3): 128–34. doi:10.1016/s1388-1981(00)00079-2. PMID 11018465.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Reiss U, Oskouian B, Zhou J, et al. (2004). "Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis". J. Biol. Chem. 279 (2): 1281–90. doi:10.1074/jbc.M309646200. PMID 14570870.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Zhan X, Desiderio DM (2006). "Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry". Anal. Biochem. 354 (2): 279–89. doi:10.1016/j.ab.2006.05.024. PMID 16777052.