RPL23A

RPL23A
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	4UG0, 4V6X, 5AJ0, 3J7R, 4V5Z, 4UJD, 3J7P, 4D67, 3J92, 4D5Y, 3J7Q, 4UJE, 3J7O, 4UJC
Identifikatori
Aliasi	RPL23A
Vanjski ID-jevi	OMIM: 602326 MGI: 3040672 HomoloGene: 133569 GeneCards: RPL23A
Lokacija gena (čovjek)
Hrom.	Hromosom 17 (čovjek)
Kraj	28,724,359 bp
Lokacija gena (miš)
Hrom.	Hromosom 11 (miš)
Kraj	78,074,410 bp
Ontologija gena
Molekularna funkcija	• rRNA binding; • structural constituent of ribosome; • GO:0001948, GO:0016582 vezivanje za proteine; • cadherin binding; • vezivanje sa RNK; • TORC2 complex binding; • large ribosomal subunit rRNA binding;
Ćelijska komponenta	• citoplazma; • citosol; • ribozom; • intracellular anatomical structure; • Jedarce; • cytosolic large ribosomal subunit; • Egzosom; • jedro; • TORC2 complex;
Biološki proces	• viral transcription; • SRP-dependent cotranslational protein targeting to membrane; • ribosomal large subunit assembly; • translational initiation; • Nonsens-posredovano propadanje iRNK; • Ćelijska proliferacija; • Biosinteza bjelančevina; • rRNA processing;
	Izvori:Amigo / QuickGO
Ortolozi
	6147
	268449
	ENSG00000198242
	ENSMUSG00000058546
	P62750
	P62751
	NM_000984
	NM_207523
	NP_000975
	NP_997406
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

60S ribosomski protein L23a je protein koji je kod ljudi kodirtan genom RPL23A.^[5]

Dužina polipeptidnog lanca je 156 aminokiselina, a molekulska težina 17.695^[6].

Aminokiselinska sekvenca

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10	20	30	40	50
MAPKAKKEAP	APPKAEAKAK	ALKAKKAVLK	GVHSHKKKKI	RTSPTFRRPK
TLRLRRQPKY	PRKSAPRRNK	LDHYAIIKFP	LTTESAMKKI	EDNNTLVFIV
DVKANKHQIK	QAVKKLYDID	VAKVNTLIRP	DGEKKAYVRL	APDYDALDVA
NKIGII

Funkcija

Ribosomi, organele koji kataliziraju sintezu proteina, sastoje se od male 40S i velike 60S podjedinice. Zajedno sastoje se od četiri tipa RNK i približno 80 strukturno različitih proteina. Ovaj gen kodira ribosomski protein koji je komponenta 60S podjedinice. Protein pripada porodici ribosomskih proteina L23P. Nalazi se u citoplazmi. Može biti jedna od ciljnih molekula koje su uključene u posredovanje u inhibiciji rasta pomoću interferona. U kvascima se odgovarajući protein veže na određeno mjesto na 26S rRNK. Ovaj gen je ko-transkribiran sa genima U42A, U42B, U101A i U101B malče nukleolusne RNK, koji se nalaze svoj treći, prvi, drugi i četvrti intron. Kao što je tipski za gene koji kodiraju ribosomske proteine, postoji više prerađenih pseudogena ovog gena raspršenih širom genoma.^[7]

Klinički značaj

L23a je identificiran kao autoimunska meta koja uzrokuje oblik reumatoidni artritis kod miševa i koji također uzrokuje reakciju T-ćelija i autoantitijela kod pacijenata sa reumatoidnim artritisom.^[8]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198242 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000058546 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Fan W, Christensen M, Eichler E, Zhang X, Lennon G (Feb 1998). "Cloning, sequencing, gene organization, and localization of the human ribosomal protein RPL23A gene". Genomics. 46 (2): 234–9. doi:10.1006/geno.1997.5038. PMID 9417910.
^ "UniProt, P62750". Pristupljeno June 11 2021. Provjerite vrijednost datuma u parametru: |access-date= (pomoć)
^ "Entrez Gene: RPL23A ribosomal protein L23a".
^ Ito Y, Hashimoto M, Hirota K, Ohkura N, Morikawa H, Nishikawa H, Tanaka A, Furu M, Ito H, Fujii T, Nomura T, Yamazaki S, Morita A, Vignali DA, Kappler JW, Matsuda S, Mimori T, Sakaguchi N, Sakaguchi S (2014). "Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease". Science. 346 (6207): 363–8. Bibcode:2014Sci...346..363I. doi:10.1126/science.1259077. PMC 5554397. PMID 25324392.

Dopunska literatura

Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
Fan W, Cai W, Parimoo S, Schwarz DC, Lennon GG, Weissman SM (1996). "Identification of seven new human MHC class I region genes around the HLA-F locus". Immunogenetics. 44 (2): 97–103. doi:10.1007/BF02660056. PMID 8662070. S2CID 21628804.
Jiang H, Lin JJ, Tao J, Fisher PB (1997). "Suppression of human ribosomal protein L23A expression during cell growth inhibition by interferon-beta". Oncogene. 14 (4): 473–80. doi:10.1038/sj.onc.1200858. PMID 9053844.
Jäkel S, Görlich D (1998). "Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells". EMBO J. 17 (15): 4491–502. doi:10.1093/emboj/17.15.4491. PMC 1170780. PMID 9687515.
Rogan S, Heaphy S (2001). "The vaccinia virus E3L protein interacts with SUMO-1 and ribosomal protein L23a in a yeast two hybrid assay". Virus Genes. 21 (3): 193–5. doi:10.1023/A:1008139514123. PMID 11129635. S2CID 8941317.
Uechi T, Tanaka T, Kenmochi N (2001). "A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders". Genomics. 72 (3): 223–30. doi:10.1006/geno.2000.6470. PMID 11401437.
Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Vanjski linkovi

PDBe-KB provides an overview of all the structure information available in the PDB for Human 60S ribosomal protein L23a

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000198242 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000058546 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9417910-5] Fan W, Christensen M, Eichler E, Zhang X, Lennon G (Feb 1998). "Cloning, sequencing, gene organization, and localization of the human ribosomal protein RPL23A gene". Genomics. 46 (2): 234–9. doi:10.1006/geno.1997.5038. PMID 9417910.

[UniProt-6] "UniProt, P62750". Pristupljeno June 11 2021. Provjerite vrijednost datuma u parametru: |access-date= (pomoć)

[entrez-7] "Entrez Gene: RPL23A ribosomal protein L23a".

[Ito_2014-8] Ito Y, Hashimoto M, Hirota K, Ohkura N, Morikawa H, Nishikawa H, Tanaka A, Furu M, Ito H, Fujii T, Nomura T, Yamazaki S, Morita A, Vignali DA, Kappler JW, Matsuda S, Mimori T, Sakaguchi N, Sakaguchi S (2014). "Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease". Science. 346 (6207): 363–8. Bibcode:2014Sci...346..363I. doi:10.1126/science.1259077. PMC 5554397. PMID 25324392.

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