RLF (gen)
Protein Rlf cinkovog prsta jest protein koji je kod ljudi kodiran genom RLF sa hromosoma 1 .[5][6]
Aminokiselinska sekvenca
urediDužina polipeptidnog lanca je 1.914 aminokiselina, a molekulska težina 217.953 Da.[7]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MADGKGDAAA | VAGAGAEAPA | VAGAGDGVET | ESMVRGHRPV | SPAPGASGLR | ||||
| PCLWQLETEL | REQEVSEVSS | LNYCRSFCQT | LLQYASNKNA | SEHIVYLLEV | ||||
| YRLAIQSFAS | ARPYLTTECE | DVLLVLGRLV | LSCFELLLSV | SESELPCEVW | ||||
| LPFLQSLQES | HDALLEFGNN | NLQILVHVTK | EGVWKNPVLL | KILSQQPVET | ||||
| EEVNKLIAQE | GPSFLQMRIK | HLLKSNCIPQ | ATALSKLCAE | SKEISNVSSF | ||||
| QQAYITCLCS | MLPNEDAIKE | IAKVDCKEVL | DIICNLESEG | QDNTAFVLCT | ||||
| TYLTQQLQTA | SVYCSWELTL | FWSKLQRRID | PSLDTFLERC | RQFGVIAKTQ | ||||
| QHLFCLIRVI | QTEAQDAGLG | VSILLCVRAL | QLRSSEDEEM | KASVCKTIAC | ||||
| LLPEDLEVRR | ACQLTEFLIE | PSLDGFNMLE | ELYLQPDQKF | DEENAPVPNS | ||||
| LRCELLLALK | AHWPFDPEFW | DWKTLKRHCH | QLLGQEASDS | DDDLSGYEMS | ||||
| INDTDVLESF | LSDYDEGKED | KQYRRRDLTD | QHKEKRDKKP | IGSSERYQRW | ||||
| LQYKFFCLLC | KRECIEARIL | HHSKMHMEDG | IYTCPVCIKK | FKRKEMFVPH | ||||
| VMEHVKMPPS | RRDRSKKKLL | LKGSQKGICP | KSPSAIPEQN | HSLNDQAKGE | ||||
| SHEYVTFSKL | EDCHLQDRDL | YPCPGTDCSR | VFKQFKYLSV | HLKAEHQNND | ||||
| ENAKHYLDMK | NRREKCTYCR | RHFMSAFHLR | EHEQVHCGPQ | PYMCVSIDCY | ||||
| ARFGSVNELL | NHKQKHDDLR | YKCELNGCNI | VFSDLGQLYH | HEAQHFRDAS | ||||
| YTCNFLGCKK | FYYSKIEYQN | HLSMHNVENS | NGDIKKSVKL | EESATGEKQD | ||||
| CINQPHLLNQ | TDKSHLPEDL | FCAESANSQI | DTETAENLKE | NSDSNSSDQL | ||||
| SHSSSASMNE | ELIDTLDHSE | TMQDVLLSNE | KVFGPSSLKE | KCSSMAVCFD | ||||
| GTKFTCGFDG | CGSTYKNARG | MQKHLRKVHP | YHFKPKKIKT | KDLFPSLGNE | ||||
| HNQTTEKLDA | EPKPCSDTNS | DSPDEGLDHN | IHIKCKREHQ | GYSSESSICA | ||||
| SKRPCTEDTM | LELLLRLKHL | SLKNSITHGS | FSGSLQGYPS | SGAKSLQSVS | ||||
| SISDLNFQNQ | DENMPSQYLA | QLAAKPFFCE | LQGCKYEFVT | REALLMHYLK | ||||
| KHNYSKEKVL | QLTMFQHRYS | PFQCHICQRS | FTRKTHLRIH | YKNKHQIGSD | ||||
| RATHKLLDNE | KCDHEGPCSV | DRLKGDCSAE | LGGDPSSNSE | KPHCHPKKDE | ||||
| CSSETDLESS | CEETESKTSD | ISSPIGSHRE | EQEGREGRGS | RRTVAKGNLC | ||||
| YILNKYHKPF | HCIHKTCNSS | FTNLKGLIRH | YRTVHQYNKE | QLCLEKDKAR | ||||
| TKRELVKCKK | IFACKYKECN | KRFLCSKALA | KHCSDSHNLD | HIEEPKVLSE | ||||
| AGSAARFSCN | QPQCPAVFYT | FNKLKHHLME | QHNIEGEIHS | DYEIHCDLNG | ||||
| CGQIFTHRSN | YSQHVYYRHK | DYYDDLFRSQ | KVANERLLRS | EKVCQTADTQ | ||||
| GHEHQTTRRS | FNAKSKKCGL | IKEKKAPISF | KTRAEALHMC | VEHSEHTQYP | ||||
| CMVQGCLSVV | KLESSIVRHY | KRTHQMSSAY | LEQQMENLVV | CVKYGTKIKE | ||||
| EPPSEADPCI | KKEENRSCES | ERTEHSHSPG | DSSAPIQNTD | CCHSSERDGG | ||||
| QKGCIESSSV | FDADTLLYRG | TLKCNHSSKT | TSLEQCNIVQ | PPPPCKIENS | ||||
| IPNPNGTESG | TYFTSFQLPL | PRIKESETRQ | HSSGQENTVK | NPTHVPKENF | ||||
| RKHSQPRSFD | LKTYKPMGFE | SSFLKFIQES | EEKEDDFDDW | EPSEHLTLSN | ||||
| SSQSSNDLTG | NVVANNMVND | SEPEVDIPHS | SSDSTIHENL | TAIPPLIVAE | ||||
| TTTVPSLENL | RVVLDKALTD | CGELALKQLH | YLRPVVVLER | SKFSTPILDL | ||||
| FPTKKTDELC | VGSS |
Reference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000117000 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000049878 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Makela TP, Kere J, Winqvist R, Alitalo K (Aug 1991). "Intrachromosomal rearrangements fusing L-myc and rlf in small-cell lung cancer". Mol Cell Biol. 11 (8): 4015–21. doi:10.1128/mcb.11.8.4015. PMC 361204. PMID 1649386.
- ^ "Entrez Gene: RLF rearranged L-myc fusion".
- ^ "UniProt, Q13129" (jezik: eng.). Pristupljeno 4. 12. 2021.CS1 održavanje: nepoznati jezik (link)
Dopunska literatura
uredi- Olsen JV; Blagoev B; Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
- Gregory SG; Barlow KF; McLay KE; et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
- Swick L, Kapatos G (2006). "A yeast 2-hybrid analysis of human GTP cyclohydrolase I protein interactions". J. Neurochem. 97 (5): 1447–55. doi:10.1111/j.1471-4159.2006.03836.x. PMC 2239266. PMID 16696853.
- Gerhard DS; Wagner L; Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Colland F; Jacq X; Trouplin V; et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
- Lanigan TM; Liu A; Huang YZ; et al. (2003). "Human homologue of Drosophila CNK interacts with Ras effector proteins Raf and Rlf". FASEB J. 17 (14): 2048–60. doi:10.1096/fj.02-1096com. hdl:2027.42/154294. PMID 14597674. S2CID 22523818.
- Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Shao H, Kadono-Okuda K, Finlin BS, Andres DA (1999). "Biochemical characterization of the Ras-related GTPases Rit and Rin". Arch. Biochem. Biophys. 371 (2): 207–19. doi:10.1006/abbi.1999.1448. PMID 10545207.
- Mäkelä TP; Hellsten E; Vesa J; et al. (1996). "The rearranged L-myc fusion gene (RLF) encodes a Zn-15 related zinc finger protein". Oncogene. 11 (12): 2699–704. PMID 8545128.