RCC2

RCC2
Identifikatori
Aliasi	RCC2
Vanjski ID-jevi	OMIM: 609587 MGI: 1919784 HomoloGene: 10282 GeneCards: RCC2
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	17,439,677 bp
Lokacija gena (miš)
Hrom.	Hromosom 4 (miš)
Kraj	140,450,531 bp
Ontologija gena
Molekularna funkcija	• protein domain specific binding; • microtubule binding; • small GTPase binding; • GO:0001948, GO:0016582 vezivanje za proteine; • protein kinase binding; • vezivanje sa RNK; • guanyl-nucleotide exchange factor activity;
Ćelijska komponenta	• citoplazma; • citosol; • early endosome membrane; • membrana; • ćelijska membrana; • Diobeno vreteno; • chromosome, centromeric core domain; • hromosom; • mitotic spindle midzone; • midbody; • Jedarce; • Mikrotubula; • Primarno suženje; • citoskelet; • jedro;
Biološki proces	• regulation of cell migration; • GO:0032861, GO:0032862, GO:0032856 activation of GTPase activity; • establishment of protein localization; • Ćelijska dioba; • chromosome passenger complex localization to kinetochore; • positive regulation of attachment of spindle microtubules to kinetochore; • focal adhesion assembly; • GO:0034259 negative regulation of GTPase activity; • regulation of ruffle assembly; • integrin-mediated signaling pathway; • positive regulation of G2/M transition of mitotic cell cycle; • ćelijski ciklus; • negative regulation of substrate adhesion-dependent cell spreading; • regulation of fibroblast migration; • negative regulation of focal adhesion assembly; • sister chromatid cohesion;
	Izvori:Amigo / QuickGO
Ortolozi
	55920
	108911
	ENSG00000281540; ENSG00000179051
	ENSMUSG00000040945
	Q9P258
	Q8BK67
	NM_018715; NM_001136204
	NM_173867
	NP_001129676; NP_061185; NP_001129676.1; NP_061185.1
	NP_776292
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Protein RCC2 poznat i kao 60-kilodaltonski protein telofaznog diska (TD-60) ili RCC1-liki protein TD-60 jest protein koji je kod ljudi kodiran genom RCC2 sa hromosoma 1.^[5]^[6]^[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 522 aminokiseline, a molekulska težina 56.085 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MPRKKAAAAA	WEEPSSGNGT	ARAGPRKRGG	PAGRKRERPE	RCSSSSGGGS
SGDEDGLELD	GAPGGGKRAA	RPATAGKAGG	AAVVITEPEH	TKERVKLEGS
KCKGQLLIFG	ATNWDLIGRK	EVPKQQAAYR	NLGQNLWGPH	RYGCLAGVRV
RTVVSGSCAA	HSLLITTEGK	LWSWGRNEKG	QLGHGDTKRV	EAPRLIEGLS
HEVIVSAACG	RNHTLALTET	GSVFAFGENK	MGQLGLGNQT	DAVPSPAQIM
YNGQPITKMA	CGAEFSMIMD	CKGNLYSFGC	PEYGQLGHNS	DGKFIARAQR
IEYDCELVPR	RVAIFIEKTK	DGQILPVPNV	VVRDVACGAN	HTLVLDSQKR
VFSWGFGGYG	RLGHAEQKDE	MVPRLVKLFD	FPGRGASQIY	AGYTCSFAVS
EVGGLFFWGA	TNTSRESTMY	PKAVQDLCGW	RIRSLACGKS	SIIVAADEST
ISWGPSPTFG	ELGYGDHKPK	SSTAAQEVKT	LDGIFSEQVA	MGYSHSLVIA
RDESETEKEK	IKKLPEYNPR	TL

Funkcija

RCC2 ima strukturnu sličnost sa RCC1 i pokazalo se da ima slabu aktivnost faktora izmjene guaninskih nukleotida (GEF) na malom GTPaznom Rac-u.^[6] Takođe se pokazalo da TD-60 stupa u interakciju sa hromosomskim prolazničkim kompleksom (CPC), i da aktivira katalitsku komponentu CPC-a, Aurora B, u prisustvu mikrotubula.^[9]^[10]

Reference

^ ^a ^b ^c ENSG00000179051 GRCh38: Ensembl release 89: ENSG00000281540, ENSG00000179051 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040945 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (Sep 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
^ ^a ^b Mollinari C, Reynaud C, Martineau-Thuillier S, Monier S, Kieffer S, Garin J, Andreassen PR, Boulet A, Goud B, Kleman JP, Margolis RL (Aug 2003). "The mammalian passenger protein TD-60 is an RCC1 family member with an essential role in prometaphase to metaphase progression". Dev Cell. 5 (2): 295–307. doi:10.1016/S1534-5807(03)00205-3. PMID 12919680.
^ "Entrez Gene: RCC2 regulator of chromosome condensation 2".
^ "UniProt, Q9P258" (jezik: eng.). Pristupljeno 4. 12. 2021.CS1 održavanje: nepoznati jezik (link)
^ Gassmann R, Carvalho A, Henzing AJ, Ruchaud S, Hudson DF, Honda R, Nigg EA, Gerloff DL, Earnshaw WC (juli 2004). "Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle". J. Cell Biol. 166 (2): 179–91. doi:10.1083/jcb.200404001. PMC 2172304. PMID 15249581.
^ Rosasco-Nitcher SE, Lan W, Khorasanizadeh S, Stukenberg PT (januar 2008). "Centromeric Aurora-B activation requires TD-60, microtubules, and substrate priming phosphorylation". Science. 319 (5862): 469–72. Bibcode:2008Sci...319..469R. doi:10.1126/science.1148980. PMID 18218899. S2CID 10374348.

Dopunska literatura

Andreassen PR, Palmer DK, Wener MH, Margolis RL (1991). "Telophase disc: a new mammalian mitotic organelle that bisects telophase cells with a possible function in cytokinesis". J. Cell Sci. 99 (3): 523–34. doi:10.1242/jcs.99.3.523. PMID 1939370.
Martineau SN, Andreassen PR, Margolis RL (1995). "Delay of HeLa cell cleavage into interphase using dihydrocytochalasin B: retention of a postmitotic spindle and telophase disc correlates with synchronous cleavage recovery". J. Cell Biol. 131 (1): 191–205. doi:10.1083/jcb.131.1.191. PMC 2120587. PMID 7559776.
Martineau-Thuillier S, Andreassen PR, Margolis RL (1999). "Colocalization of TD-60 and INCENP throughout G2 and mitosis: evidence for their possible interaction in signalling cytokinesis". Chromosoma. 107 (6–7): 461–70. doi:10.1007/s004120050330. PMID 9914378. S2CID 24935187.
Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gassmann R, Carvalho A, Henzing AJ, et al. (2004). "Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle". J. Cell Biol. 166 (2): 179–91. doi:10.1083/jcb.200404001. PMC 2172304. PMID 15249581.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Rosasco-Nitcher, Sara; Lan W; Khorasanizadeh S; Stukenberg PT. (januar 2008). "Centromeric Aurora-B activation requires TD-60, microtubules, and substrate priming phosphorylation". Science. 319 (5862): 469–472. Bibcode:2008Sci...319..469R. doi:10.1126/science.1148980. PMID 18218899. S2CID 10374348.

Vanjski linkovi

Q9P258

[refGRCh38Ensembl-1] ENSG00000179051 GRCh38: Ensembl release 89: ENSG00000281540, ENSG00000179051 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040945 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10819331-5] Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (Sep 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.

[pmid12919680-6] Mollinari C, Reynaud C, Martineau-Thuillier S, Monier S, Kieffer S, Garin J, Andreassen PR, Boulet A, Goud B, Kleman JP, Margolis RL (Aug 2003). "The mammalian passenger protein TD-60 is an RCC1 family member with an essential role in prometaphase to metaphase progression". Dev Cell. 5 (2): 295–307. doi:10.1016/S1534-5807(03)00205-3. PMID 12919680.

[entrez-7] "Entrez Gene: RCC2 regulator of chromosome condensation 2".

[UniProt-8] "UniProt, Q9P258" (jezik: eng.). Pristupljeno 4. 12. 2021.CS1 održavanje: nepoznati jezik (link)

[pmid15249581-9] Gassmann R, Carvalho A, Henzing AJ, Ruchaud S, Hudson DF, Honda R, Nigg EA, Gerloff DL, Earnshaw WC (juli 2004). "Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle". J. Cell Biol. 166 (2): 179–91. doi:10.1083/jcb.200404001. PMC 2172304. PMID 15249581.

[pmid18218899-10] Rosasco-Nitcher SE, Lan W, Khorasanizadeh S, Stukenberg PT (januar 2008). "Centromeric Aurora-B activation requires TD-60, microtubules, and substrate priming phosphorylation". Science. 319 (5862): 469–72. Bibcode:2008Sci...319..469R. doi:10.1126/science.1148980. PMID 18218899. S2CID 10374348.

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