Aminokiselinska sekvenca
uredi
Dužina polipeptidnog lanca je 1.123 aminokiseline , а molekulska težina 128.644 Da .[ 8] .
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MWGDSRPANR TGPFRGSQEE RFAPGWNRDY PPPPLKSHAQ ERHSGNFPGR
DSLPFDFQGH SGPPFANVEE HSFSYGARDG PHGDYRGGEG PGHDFRGGDF
SSSDFQSRDS SQLDFRGRDI HSGDFRDREG PPMDYRGGDG TSMDYRGREA
PHMNYRDRDA HAVDFRGRDA PPSDFRGRGT YDLDFRGRDG SHADFRGRDL
SDLDFRAREQ SRSDFRNRDV SDLDFRDKDG TQVDFRGRGS GTTDLDFRDR
DTPHSDFRGR HRSRTDQDFR GREMGSCMEF KDREMPPVDP NILDYIQPST
QDREHSGMNV NRREESTHDH TIERPAFGIQ KGEFEHSETR EGETQGVAFE
HESPADFQNS QSPVQDQDKS QLSGREEQSS DAGLFKEEGG LDFLGRQDTD
YRSMEYRDVD HRLPGSQMFG YGQSKSFPEG KTARDAQRDL QDQDYRTGPS
EEKPSRLIRL SGVPEDATKE EILNAFRTPD GMPVKNLQLK EYNTGYDYGY
VCVEFSLLED AIGCMEANQG TLMIQDKEVT LEYVSSLDFW YCKRCKANIG
GHRSSCSFCK NPREVTEAKQ ELITYPQPQK TSIPAPLEKQ PNQPLRPADK
EPEPRKREEG QESRLGHQKR EAERYLPPSR REGPTFRRDR ERESWSGETR
QDGESKTIML KRIYRSTPPE VIVEVLEPYV RLTTANVRII KNRTGPMGHT
YGFIDLDSHA EALRVVKILQ NLDPPFSIDG KMVAVNLATG KRRNDSGDHS
DHMHYYQGKK YFRDRRGGGR NSDWSSDTNR QGQQSSSDCY IYDSATGYYY
DPLAGTYYDP NTQQEVYVPQ DPGLPEEEEI KEKKPTSQGK SSSKKEMSKR
DGKEKKDRGV TRFQENASEG KAPAEDVFKK PLPPTVKKEE SPPPPKVVNP
LIGLLGEYGG DSDYEEEEEE EQTPPPQPRT AQPQKREEQT KKENEEDKLT
DWNKLACLLC RRQFPNKEVL IKHQQLSDLH KQNLEIHRKI KQSEQELAYL
ERREREGKFK GRGNDRREKL QSFDSPERKR IKYSRETDSD RKLVDKEDID
TSSKGGCVQQ ATGWRKGTGL GYGHPGLASS EEAEGRMRGP SVGASGRTSK
RQSNETYRDA VRRVMFARYK ELD
^ a b c GRCh38: Ensembl release 89: ENSG00000004534 - Ensembl , maj 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032582 - Ensembl , maj 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Timmer T, Terpstra P, van den Berg A, Veldhuis PM, Ter Elst A, Voutsinas G, Hulsbeek MM, Draaijers TG, Looman MW, Kok K, Naylor SL, Buys CH (Aug 1999). "A comparison of genomic structures and expression patterns of two closely related flanking genes in a critical lung cancer region at 3p21.3" . Eur J Hum Genet . 7 (4): 478–86. doi :10.1038/sj.ejhg.5200334 . PMID 10352938 .
^ "Entrez Gene: RBM6 RNA binding motif protein 6" .
^ "OrthoMaM phylogenetic marker: RBM6 coding sequence" . Arhivirano s originala , 3. 3. 2016. Pristupljeno 5. 11. 2021 .
^ "UniProt, P78332" (jezik: engleski). Pristupljeno 5. 11. 2021 .
Dopunska literatura
uredi
Güre AO, Altorki NK, Stockert E, et al. (1998). "Human lung cancer antigens recognized by autologous antibodies: definition of a novel cDNA derived from the tumor suppressor gene locus on chromosome 3p21.3". Cancer Res . 58 (5): 1034–41. PMID 9500467 .
Drabkin HA, West JD, Hotfilder M, et al. (1999). "DEF-3(g16/NY-LU-12), an RNA binding protein from the 3p21.3 homozygous deletion region in SCLC" . Oncogene . 18 (16): 2589–97. doi :10.1038/sj.onc.1202601 . PMID 10353602 .
Timmer T, Terpstra P, van den Berg A, et al. (1999). "An evolutionary rearrangement of the Xp11.3-11.23 region in 3p21.3, a region frequently deleted in a variety of cancers". Genomics . 60 (2): 238–40. doi :10.1006/geno.1999.5878 . PMID 10486216 .
Lerman MI, Minna JD (2000). "The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium". Cancer Res . 60 (21): 6116–33. PMID 11085536 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 . PMID 14702039 .
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proc. Natl. Acad. Sci. U.S.A . 101 (33): 12130–5. doi :10.1073/pnas.0404720101 . PMC 514446 . PMID 15302935 .
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization" . Nat. Biotechnol . 24 (10): 1285–92. doi :10.1038/nbt1240 . PMID 16964243 . S2CID 14294292 .
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48. doi :10.1016/j.cell.2006.09.026 . PMID 17081983 . S2CID 7827573 .
Gu TL, Mercher T, Tyner JW, et al. (2007). "A novel fusion of RBM6 to CSF1R in acute megakaryoblastic leukemia" . Blood . 110 (1): 323–33. doi :10.1182/blood-2006-10-052282 . PMC 1896120 . PMID 17360941 .
Wang K, Ubriaco G, Sutherland LC (2007). "RBM6-RBM5 transcription-induced chimeras are differentially expressed in tumours" . BMC Genomics . 8 : 348. doi :10.1186/1471-2164-8-348 . PMC 2174484 . PMID 17908320 .