Difosfoinozitol-pentakisfosfatna kinaza 2 jest protein/enzim koji je kod ljudi kodiran genom PPIP5K2 sa hromosoma 5.[5]

PPIP5K2
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

3T54, 3T7A, 3T99, 3T9A, 3T9B, 3T9C, 3T9D, 3T9E, 3T9F, 4HN2, 4NZM, 4NZN, 4NZO, 4Q4C, 4Q4D, 5BYA, 5BYB

Identifikatori
AliasiPPIP5K2
Vanjski ID-jeviOMIM: 611648 MGI: 2142810 HomoloGene: 49409 GeneCards: PPIP5K2
Lokacija gena (čovjek)
Hromosom 5 (čovjek)
Hrom.Hromosom 5 (čovjek)[1]
Hromosom 5 (čovjek)
Genomska lokacija za PPIP5K2
Genomska lokacija za PPIP5K2
Bend5q21.1Početak103,120,149 bp[1]
Kraj103,212,799 bp[1]
Lokacija gena (miš)
Hromosom 1 (miš)
Hrom.Hromosom 1 (miš)[2]
Hromosom 1 (miš)
Genomska lokacija za PPIP5K2
Genomska lokacija za PPIP5K2
Bend1|1 DPočetak97,706,048 bp[2]
Kraj97,770,411 bp[2]
Ontologija gena
Molekularna funkcija inositol hexakisphosphate 5-kinase activity
transferase activity
inositol hexakisphosphate 1-kinase activity
nucleotide binding
diphosphoinositol-pentakisphosphate kinase activity
inositol-1,3,4,5,6-pentakisphosphate kinase activity
inositol hexakisphosphate 3-kinase activity
kinase activity
inositol hexakisphosphate kinase activity
ATP binding
inositol heptakisphosphate kinase activity
5-diphosphoinositol pentakisphosphate 3-kinase activity
Ćelijska komponenta citoplazma
citosol
Biološki proces inositol phosphate metabolic process
Fosforilacija
inositol phosphate biosynthetic process
inositol metabolic process
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)
NM_001276277
NM_001281471
NM_015216
NM_001345871
NM_001345872

NM_001345873
NM_001345874
NM_001345875
NM_001345876
NM_001345877
NM_001345878

NM_173760

RefSeq (bjelančevina)
NP_001263206
NP_001268400
NP_001332800
NP_001332801
NP_001332802

NP_001332803
NP_001332804
NP_001332805
NP_001332806
NP_001332807
NP_056031

NP_776121
NP_001392387
NP_001392388
NP_001392389
NP_001392390

NP_001392391
NP_001392392
NP_001392393
NP_001392394
NP_001392395
NP_001392396
NP_001392397
NP_001392398
NP_001392399
NP_001392400
NP_001392401
NP_001392402

Lokacija (UCSC)Chr 5: 103.12 – 103.21 MbChr 1: 97.71 – 97.77 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca uredi

Dužina polipeptidnog lanca je 1.243 aminokiseline, а molekulska težina 140.407 Da.[6]

1020304050
MSEAPRFFVGPEDTEINPGNYRHFFHHADEDDEEEDDSPPERQIVVGICS
MAKKSKSKPMKEILERISLFKYITVVVFEEEVILNEPVENWPLCDCLISF
HSKGFPLDKAVAYAKLRNPFVINDLNMQYLIQDRREVYSILQAEGILLPR
YAILNRDPNNPKECNLIEGEDHVEVNGEVFQKPFVEKPVSAEDHNVYIYY
PTSAGGGSQRLFRKIGSRSSVYSPESNVRKTGSYIYEEFMPTDGTDVKVY
TVGPDYAHAEARKSPALDGKVERDSEGKEVRYPVILNAREKLIAWKVCLA
FKQTVCGFDLLRANGQSYVCDVNGFSFVKNSMKYYDDCAKILGNIVMREL
APQFHIPWSIPLEAEDIPIVPTTSGTMMELRCVIAVIRHGDRTPKQKMKM
EVRHQKFFDLFEKCDGYKSGKLKLKKPKQLQEVLDIARQLLMELGQNNDS
EIEENKPKLEQLKTVLEMYGHFSGINRKVQLTYLPHGCPKTSSEEEDSRR
EEPSLLLVLKWGGELTPAGRVQAEELGRAFRCMYPGGQGDYAGFPGCGLL
RLHSTYRHDLKIYASDEGRVQMTAAAFAKGLLALEGELTPILVQMVKSAN
MNGLLDSDSDSLSSCQQRVKARLHEILQKDRDFTAEDYEKLTPSGSISLI
KSMHLIKNPVKTCDKVYSLIQSLTSQIRHRMEDPKSSDIQLYHSETLELM
LRRWSKLEKDFKTKNGRYDISKIPDIYDCIKYDVQHNGSLKLENTMELYR
LSKALADIVIPQEYGITKAEKLEIAKGYCTPLVRKIRSDLQRTQDDDTVN
KLHPVYSRGVLSPERHVRTRLYFTSESHVHSLLSILRYGALCNESKDEQW
KRAMDYLNVVNELNYMTQIVIMLYEDPNKDLSSEERFHVELHFSPGAKGC
EEDKNLPSGYGYRPASRENEGRRPFKIDNDDEPHTSKRDEVDRAVILFKP
MVSEPIHIHRKSPLPRSRKTATNDEESPLSVSSPEGTGTWLHYTSGVGTG
RRRRRSGEQITSSPVSPKSLAFTSSIFGSWQQVVSENANYLRTPRTLVEQ
KQNPTVGSHCAGLFSTSVLGGSSSAPNLQDYARTHRKKLTSSGCIDDATR
GSAVKRFSISFARHPTNGFELYSMVPSICPLETLHNALSLKQVDEFLASI
ASPSSDVPRKTAEISSTALRSSPIMRKKVSLNTYTPAKILPTPPATLKST
KASSKPATSGPSSAVVPNTSSRKKNITSKTETHEHKKNTGKKK

Funkcija uredi

Inozitol-fosfati (IP) i difosfoinozitol-fosfati (PP-IP), poznati i kao inozitol-pirofosfati, djeluju kao molekule ćelijske signalizacije.

HISPPD1 ima aktivnosti IP6 kinaza (EC: 2.7.4.21) i PP-IP5 (također zvane IP7) kinaze (EC: 2.7.4.24) koje proizvode visokoenergetske pirofosfate PP-IP5 i PP2 -IP4 (naziva se i IP8) (Fridy et al., 2007 PubMed 17690096]).

Reference uredi

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000145725 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040648 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Diphosphoinositol pentakisphosphate kinase 2". Pristupljeno 21. 3. 2017.
  6. ^ "UniProt, O43314" (jezik: engleski). Pristupljeno 19. 10. 2021.

Dopunska literatura uredi

Vanjski linkovi uredi

Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.