PPIP5K2

PPIP5K2
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	3T54, 3T7A, 3T99, 3T9A, 3T9B, 3T9C, 3T9D, 3T9E, 3T9F, 4HN2, 4NZM, 4NZN, 4NZO, 4Q4C, 4Q4D, 5BYA, 5BYB
Identifikatori
Aliasi	PPIP5K2
Vanjski ID-jevi	OMIM: 611648 MGI: 2142810 HomoloGene: 49409 GeneCards: PPIP5K2
Lokacija gena (čovjek)
Hrom.	Hromosom 5 (čovjek)
Kraj	103,212,799 bp
Lokacija gena (miš)
Hrom.	Hromosom 1 (miš)
Kraj	97,770,411 bp
Ontologija gena
Molekularna funkcija	• inositol hexakisphosphate 5-kinase activity; • aktivnost sa transferazom; • inositol hexakisphosphate 1-kinase activity; • nucleotide binding; • diphosphoinositol-pentakisphosphate kinase activity; • inositol-1,3,4,5,6-pentakisphosphate kinase activity; • inositol hexakisphosphate 3-kinase activity; • kinase activity; • inositol hexakisphosphate kinase activity; • ATP binding; • inositol heptakisphosphate kinase activity; • 5-diphosphoinositol pentakisphosphate 3-kinase activity;
Ćelijska komponenta	• citoplazma; • citosol;
Biološki proces	• inositol phosphate metabolic process; • Fosforilacija; • inositol phosphate biosynthetic process; • inositol metabolic process;
	Izvori:Amigo / QuickGO
Ortolozi
	23262
	227399
	ENSG00000145725
	ENSMUSG00000040648
	O43314
	Q6ZQB6
NM_001276277; NM_001281471; NM_015216; NM_001345871; NM_001345872;
	NM_001345873; NM_001345874; NM_001345875; NM_001345876; NM_001345877; NM_001345878
	NM_173760
NP_001263206; NP_001268400; NP_001332800; NP_001332801; NP_001332802;
	NP_001332803; NP_001332804; NP_001332805; NP_001332806; NP_001332807; NP_056031
NP_776121; NP_001392387; NP_001392388; NP_001392389; NP_001392390;
	NP_001392391; NP_001392392; NP_001392393; NP_001392394; NP_001392395; NP_001392396; NP_001392397; NP_001392398; NP_001392399; NP_001392400; NP_001392401; NP_001392402
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Difosfoinozitol-pentakisfosfatna kinaza 2 jest protein/enzim koji je kod ljudi kodiran genom PPIP5K2 sa hromosoma 5.^[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 1.243 aminokiseline, а molekulska težina 140.407 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MSEAPRFFVG	PEDTEINPGN	YRHFFHHADE	DDEEEDDSPP	ERQIVVGICS
MAKKSKSKPM	KEILERISLF	KYITVVVFEE	EVILNEPVEN	WPLCDCLISF
HSKGFPLDKA	VAYAKLRNPF	VINDLNMQYL	IQDRREVYSI	LQAEGILLPR
YAILNRDPNN	PKECNLIEGE	DHVEVNGEVF	QKPFVEKPVS	AEDHNVYIYY
PTSAGGGSQR	LFRKIGSRSS	VYSPESNVRK	TGSYIYEEFM	PTDGTDVKVY
TVGPDYAHAE	ARKSPALDGK	VERDSEGKEV	RYPVILNARE	KLIAWKVCLA
FKQTVCGFDL	LRANGQSYVC	DVNGFSFVKN	SMKYYDDCAK	ILGNIVMREL
APQFHIPWSI	PLEAEDIPIV	PTTSGTMMEL	RCVIAVIRHG	DRTPKQKMKM
EVRHQKFFDL	FEKCDGYKSG	KLKLKKPKQL	QEVLDIARQL	LMELGQNNDS
EIEENKPKLE	QLKTVLEMYG	HFSGINRKVQ	LTYLPHGCPK	TSSEEEDSRR
EEPSLLLVLK	WGGELTPAGR	VQAEELGRAF	RCMYPGGQGD	YAGFPGCGLL
RLHSTYRHDL	KIYASDEGRV	QMTAAAFAKG	LLALEGELTP	ILVQMVKSAN
MNGLLDSDSD	SLSSCQQRVK	ARLHEILQKD	RDFTAEDYEK	LTPSGSISLI
KSMHLIKNPV	KTCDKVYSLI	QSLTSQIRHR	MEDPKSSDIQ	LYHSETLELM
LRRWSKLEKD	FKTKNGRYDI	SKIPDIYDCI	KYDVQHNGSL	KLENTMELYR
LSKALADIVI	PQEYGITKAE	KLEIAKGYCT	PLVRKIRSDL	QRTQDDDTVN
KLHPVYSRGV	LSPERHVRTR	LYFTSESHVH	SLLSILRYGA	LCNESKDEQW
KRAMDYLNVV	NELNYMTQIV	IMLYEDPNKD	LSSEERFHVE	LHFSPGAKGC
EEDKNLPSGY	GYRPASRENE	GRRPFKIDND	DEPHTSKRDE	VDRAVILFKP
MVSEPIHIHR	KSPLPRSRKT	ATNDEESPLS	VSSPEGTGTW	LHYTSGVGTG
RRRRRSGEQI	TSSPVSPKSL	AFTSSIFGSW	QQVVSENANY	LRTPRTLVEQ
KQNPTVGSHC	AGLFSTSVLG	GSSSAPNLQD	YARTHRKKLT	SSGCIDDATR
GSAVKRFSIS	FARHPTNGFE	LYSMVPSICP	LETLHNALSL	KQVDEFLASI
ASPSSDVPRK	TAEISSTALR	SSPIMRKKVS	LNTYTPAKIL	PTPPATLKST
KASSKPATSG	PSSAVVPNTS	SRKKNITSKT	ETHEHKKNTG	KKK

Funkcija

Inozitol-fosfati (IP) i difosfoinozitol-fosfati (PP-IP), poznati i kao inozitol-pirofosfati, djeluju kao molekule ćelijske signalizacije.

HISPPD1 ima aktivnosti IP6 kinaza (EC: 2.7.4.21) i PP-IP5 (također zvane IP7) kinaze (EC: 2.7.4.24) koje proizvode visokoenergetske pirofosfate PP-IP5 i PP2 -IP4 (naziva se i IP8) (Fridy et al., 2007 PubMed 17690096]).

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000145725 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040648 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Diphosphoinositol pentakisphosphate kinase 2". Pristupljeno 21. 3. 2017.
^ "UniProt, O43314" (jezik: engleski). Pristupljeno 19. 10. 2021.

Dopunska literatura

Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
Wang H, Falck JR, Hall TM, Shears SB (2011). "Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding". Nat. Chem. Biol. 8 (1): 111–6. doi:10.1038/nchembio.733. PMC 3923263. PMID 22119861.
Weaver JD, Wang H, Shears SB (2013). "The kinetic properties of a human PPIP5K reveal that its kinase activities are protected against the consequences of a deteriorating cellular bioenergetic environment". Biosci. Rep. 33 (2): e00022. doi:10.1042/BSR20120115. PMC 3564036. PMID 23240582.
Yong ST, Nguyen HN, Choi JH, Bortner CD, Williams J, Pulloor NK, Krishnan MN, Shears SB (2015). "Identification of a functional nuclear translocation sequence in hPPIP5K2". BMC Cell Biol. 16: 17. doi:10.1186/s12860-015-0063-7. PMC 4472268. PMID 26084399.

Vanjski linkovi

Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000145725 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040648 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Diphosphoinositol pentakisphosphate kinase 2". Pristupljeno 21. 3. 2017.

[UniProt-6] "UniProt, O43314" (jezik: engleski). Pristupljeno 19. 10. 2021.

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