PIP5K1A

Fosfatidilinozitol-4-fosfat 5-kinaza tip-1 alfa jest enzim koji je kod ljudi kodiran genom PIP5K1A sa hromosoma 1.

PIP5K1A
Identifikatori
Aliasi	PIP5K1A
Vanjski ID-jevi	OMIM: 603275 MGI: 107929 HomoloGene: 93492 GeneCards: PIP5K1A
Lokacija gena (čovjek) Hrom. Hromosom 1 (čovjek) Bend 1q21.3 Početak 151,197,949 bp Kraj 151,249,536 bp
Lokacija gena (miš) Hrom. Hromosom 3 (miš) Bend 3|3 F2.1 Početak 95,058,530 bp Kraj 95,106,930 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • aktivnost sa transferazom • nucleotide binding • 1-phosphatidylinositol-4-phosphate 5-kinase activity • kinase activity • kinase binding • GO:0001948, GO:0016582 vezivanje za proteine • phosphatidylinositol phosphate kinase activity • ATP binding • 1-phosphatidylinositol-3-phosphate 5-kinase activity • 1-phosphatidylinositol-5-kinase activity • phosphatidylinositol-3,4-bisphosphate 5-kinase activity • 1-phosphatidylinositol-3-phosphate 4-kinase activity Ćelijska komponenta • nuclear speck • mRNA cleavage and polyadenylation specificity factor complex • projekcija ćelije • membrana • focal adhesion • ruffle • ćelijska membrana • nukleoplazma • ruffle membrane • jedro • lamellipodium • citoplazma • citosol Biološki proces • fibroblast migration • actin cytoskeleton reorganization • phosphatidylinositol metabolic process • GO:0032861, GO:0032862, GO:0032856 activation of GTPase activity • Fosforilacija • keratinocyte differentiation • focal adhesion assembly • phospholipid biosynthetic process • Fagocitoza • cell chemotaxis • glycerophospholipid metabolic process • ruffle assembly • Ćelijska migracija • GO:0072468 Transdukcija signala • phosphatidylinositol phosphate biosynthetic process • regulation of phosphatidylinositol 3-kinase signaling • phosphatidylinositol biosynthetic process • protein localization to plasma membrane Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	8394	18720
Ensembl	ENSG00000143398	ENSMUSG00000028126
UniProt	Q99755	P70182
RefSeq (mRNK)	NM_001135636 NM_001135637 NM_001135638 NM_003557 NM_001330689	NM_001293707 NM_008847
RefSeq (bjelančevina)	NP_001129108 NP_001129109 NP_001129110 NP_001317618 NP_003548	NP_001280636 NP_032873
Lokacija (UCSC)	Chr 1: 151.2 – 151.25 Mb	Chr 3: 95.06 – 95.11 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 562 aminokiseline, a molekulska težina 62.633 Da.

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MASASSGPSS		SVGFSSFDPA		VPSCTLSSAA		SGIKRPMASE		VLEARQDSYI
SLVPYASGMP		IKKIGHRSVD		SSGETTYKKT		TSSALKGAIQ		LGITHTVGSL
STKPERDVLM		QDFYVVESIF		FPSEGSNLTP		AHHYNDFRFK		TYAPVAFRYF
RELFGIRPDD		YLYSLCSEPL		IELCSSGASG		SLFYVSSDDE		FIIKTVQHKE
AEFLQKLLPG		YYMNLNQNPR		TLLPKFYGLY		CVQAGGKNIR		IVVMNNLLPR
SVKMHIKYDL		KGSTYKRRAS		QKEREKPLPT		FKDLDFLQDI		PDGLFLDADM
YNALCKTLQR		DCLVLQSFKI		MDYSLLMSIH		NIDHAQREPL		SSETQYSVDT
RRPAPQKALY		STAMESIQGE		ARRGGTMETD		DHMGGIPARN		SKGERLLLYI
GIIDILQSYR		FVKKLEHSWK		ALVHDGDTVS		VHRPGFYAER		FQRFMCNTVF
KKIPLKPSPS		KKFRSGSSFS		RRAGSSGNSC		ITYQPSVSGE		HKAQVTTKAE
VEPGVHLGRP		DVLPQTPPLE		EISEGSPIPD		PSFSPLVGET		LQMLTTSTTL
EKLEVAESEF		TH

Dopunska literatura

• Honda A, Nogami M, Yokozeki T, et al. (1999). "Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation". Cell. 99 (5): 521–32. doi:10.1016/S0092-8674(00)81540-8. PMID 10589680. S2CID 10031591.
• Jones DH, Morris JB, Morgan CP, et al. (2000). "Type I phosphatidylinositol 4-phosphate 5-kinase directly interacts with ADP-ribosylation factor 1 and is responsible for phosphatidylinositol 4,5-bisphosphate synthesis in the golgi compartment". J. Biol. Chem. 275 (18): 13962–6. doi:10.1074/jbc.C901019199. PMID 10747863.
• Divecha N, Roefs M, Halstead JR, et al. (2000). "Interaction of the type Ialpha PIPkinase with phospholipase D: a role for the local generation of phosphatidylinositol 4, 5-bisphosphate in the regulation of PLD2 activity". EMBO J. 19 (20): 5440–9. doi:10.1093/emboj/19.20.5440. PMC 314009. PMID 11032811.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Doughman RL, Firestone AJ, Wojtasiak ML, et al. (2003). "Membrane ruffling requires coordination between type Ialpha phosphatidylinositol phosphate kinase and Rac signaling". J. Biol. Chem. 278 (25): 23036–45. doi:10.1074/jbc.M211397200. PMID 12682053.
• Chang JD, Field SJ, Rameh LE, et al. (2004). "Identification and characterization of a phosphoinositide phosphate kinase homolog". J. Biol. Chem. 279 (12): 11672–9. doi:10.1074/jbc.M309721200. PMID 14701839.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kisseleva M, Feng Y, Ward M, et al. (2005). "The LIM protein Ajuba regulates phosphatidylinositol 4,5-bisphosphate levels in migrating cells through an interaction with and activation of PIPKI alpha". Mol. Cell. Biol. 25 (10): 3956–66. doi:10.1128/MCB.25.10.3956-3966.2005. PMC 1087706. PMID 15870270.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
• Halstead JR, van Rheenen J, Snel MH, et al. (2006). "A role for PtdIns(4,5)P2 and PIP5Kalpha in regulating stress-induced apoptosis". Curr. Biol. 16 (18): 1850–6. doi:10.1016/j.cub.2006.07.066. PMID 16979564. S2CID 15282445.
• Im YJ, Perera IY, Brglez I, et al. (2007). "Increasing plasma membrane phosphatidylinositol(4,5)bisphosphate biosynthesis increases phosphoinositide metabolism in Nicotiana tabacum". Plant Cell. 19 (5): 1603–16. doi:10.1105/tpc.107.051367. PMC 1913725. PMID 17496116.