PI4K2B

PI4K2B
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	4WTV
Identifikatori
Aliasi	PI4K2B
Vanjski ID-jevi	OMIM: 612101 MGI: 1914323 HomoloGene: 32405 GeneCards: PI4K2B
Lokacija gena (čovjek)
Hrom.	Hromosom 4 (čovjek)
Kraj	25,279,204 bp
Lokacija gena (miš)
Hrom.	Hromosom 5 (miš)
Kraj	52,926,682 bp
Ontologija gena
Molekularna funkcija	• aktivnost sa transferazom; • nucleotide binding; • ATP binding; • kinase activity; • 1-phosphatidylinositol 4-kinase activity;
Ćelijska komponenta	• citosol; • membrana; • citoplazma; • lysosomal membrane; • endozom; • trans-Golđijeva mreža; • ćelijska membrana;
Biološki proces	• phosphatidylinositol biosynthetic process; • Fosforilacija; • Golgi organization; • endosome organization; • phosphatidylinositol phosphate biosynthetic process;
	Izvori:Amigo / QuickGO
Ortolozi
	55300
	67073
	ENSG00000038210
	ENSMUSG00000029186
	Q8TCG2
	Q8CBQ5
	NM_018323
	NM_025951; NM_028744
	NP_060793
	NP_080227; NP_083020
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Fosfatidilinozitolna 4-kinaza tip 2-beta jest enzim koji je kod ljudi kodiran genom PI4K2B sa hromosoma 4.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 481 aminokiselina, а molekulska težina 54.744 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MEDPSEPDRL	ASADGGSPEE	EEDGEREPLL	PRIAWAHPRR	GAPGSAVRLL
DAAGEEGEAG	DEELPLPPGD	VGVSRSSSAE	LDRSRPAVSV	TIGTSEMNAF
LDDPEFADIM	LRAEQAIEVG	IFPERISQGS	SGSYFVKDPK	RKIIGVFKPK
SEEPYGQLNP	KWTKYVHKVC	CPCCFGRGCL	IPNQGYLSEA	GAYLVDNKLH
LSIVPKTKVV	WLVSETFNYN	AIDRAKSRGK	KYALEKVPKV	GRKFHRIGLP
PKIGSFQLFV	EGYKEAEYWL	RKFEADPLPE	NIRKQFQSQF	ERLVILDYII
RNTDRGNDNW	LVRYEKQKCE	KEIDHKESKW	IDDEEFLIKI	AAIDNGLAFP
FKHPDEWRAY	PFHWAWLPQA	KVPFSEEIRN	LILPYISDMN	FVQDLCEDLY
ELFKTDKGFD	KATFESQMSV	MRGQILNLTQ	ALRDGKSPFQ	LVQIPCVIVE
RSQGGSQGRI	VHLSNSFTQT	VNCRKPFFSS	W

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000038210 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029186 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Balla A, Tuymetova G, Barshishat M, Geiszt M, Balla T (maj 2002). "Characterization of type II phosphatidylinositol 4-kinase isoforms reveals association of the enzymes with endosomal vesicular compartments". J Biol Chem. 277 (22): 20041–50. doi:10.1074/jbc.M111807200. PMID 11923287.
^ "Entrez Gene: PI4K2B phosphatidylinositol 4-kinase type 2 beta".
^ "UniProt, Q8TCG2" (jezik: engleski). Pristupljeno 30. 10. 2021.

Dopunska literatura

Griffioen M, van der Meijden ED, Slager EH, et al. (2008). "Identification of phosphatidylinositol 4-kinase type II beta as HLA class II-restricted target in graft versus leukemia reactivity". Proc. Natl. Acad. Sci. U.S.A. 105 (10): 3837–42. doi:10.1073/pnas.0712250105. PMC 2268788. PMID 18316730.
Jones DR, Bultsma Y, Keune WJ, et al. (2006). "Nuclear PtdIns5P as a transducer of stress signaling: an in vivo role for PIP4Kbeta". Mol. Cell. 23 (5): 685–95. doi:10.1016/j.molcel.2006.07.014. PMID 16949365.
Srivastava R, Sinha RK, Subrahmanyam G (2006). "Type II phosphatidylinositol 4-kinase beta associates with TCR-CD3 zeta chain in Jurkat cells". Mol. Immunol. 43 (5): 454–63. doi:10.1016/j.molimm.2005.03.009. PMID 16337488.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Wei YJ, Sun HQ, Yamamoto M, et al. (2003). "Type II phosphatidylinositol 4-kinase beta is a cytosolic and peripheral membrane protein that is recruited to the plasma membrane and activated by Rac-GTP". J. Biol. Chem. 277 (48): 46586–93. doi:10.1074/jbc.M206860200. PMID 12324459.
Mora S, Durham PL, Smith JR, et al. (2002). "NCS-1 inhibits insulin-stimulated GLUT4 translocation in 3T3L1 adipocytes through a phosphatidylinositol 4-kinase-dependent pathway". J. Biol. Chem. 277 (30): 27494–500. doi:10.1074/jbc.M203669200. PMID 12011096.
Huang C, Handlogten ME, Miller RT (2002). "Parallel activation of phosphatidylinositol 4-kinase and phospholipase C by the extracellular calcium-sensing receptor". J. Biol. Chem. 277 (23): 20293–300. doi:10.1074/jbc.M200831200. PMID 11907035.

Vanjski linkovi

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000038210 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029186 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11923287-5] Balla A, Tuymetova G, Barshishat M, Geiszt M, Balla T (maj 2002). "Characterization of type II phosphatidylinositol 4-kinase isoforms reveals association of the enzymes with endosomal vesicular compartments". J Biol Chem. 277 (22): 20041–50. doi:10.1074/jbc.M111807200. PMID 11923287.

[entrez-6] "Entrez Gene: PI4K2B phosphatidylinositol 4-kinase type 2 beta".

[UniProt-7] "UniProt, Q8TCG2" (jezik: engleski). Pristupljeno 30. 10. 2021.

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