OLA1

OLA1
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2OHF
Identifikatori
Aliasi	OLA1
Vanjski ID-jevi	OMIM: 611175 MGI: 1914309 HomoloGene: 5361 GeneCards: OLA1
Lokacija gena (čovjek)
Hrom.	Hromosom 2 (čovjek)
Kraj	174,248,599 bp
Lokacija gena (miš)
Hrom.	Hromosom 2 (miš)
Kraj	73,049,268 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• nucleotide binding; • GTP binding; • GO:0001948, GO:0016582 vezivanje za proteine; • hydrolase activity; • vezivanje iona metala; • ATP binding; • ATPase activity; • cadherin binding; • ribosome binding; • ribosomal large subunit binding;
Ćelijska komponenta	• centrosom; • Jedarce; • Egzosom; • membrana; • jedro; • extracellular region; • citoplazma; • citosol; • platelet alpha granule lumen;
Biološki proces	• ATP metabolic process; • platelet degranulation;
	Izvori:Amigo / QuickGO
Ortolozi
	29789
	67059
	ENSG00000138430
	ENSMUSG00000027108
	Q9NTK5
	Q9CZ30
	NM_013341; NM_001011708; NM_001328688
	NM_025942; NM_030091
	NP_001011708; NP_001315617; NP_037473
	NP_080218; NP_084367
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Obg-lika ATPaza 1 jest enzim koji je kod ljudi kodiran genom OLA1 sa hromosoma 2.^[5]^[6]

Amiokiselininska sekvenca uredi

Dužina polipeptidnog lanca je 396 aminokiselina, a molekulska težina 44.744 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MPPKKGGDGI	KPPPIIGRFG	TSLKIGIVGL	PNVGKSTFFN	VLTNSQASAE
NFPFCTIDPN	ESRVPVPDER	FDFLCQYHKP	ASKIPAFLNV	VDIAGLVKGA
HNGQGLGNAF	LSHISACDGI	FHLTRAFEDD	DITHVEGSVD	PIRDIEIIHE
ELQLKDEEMI	GPIIDKLEKV	AVRGGDKKLK	PEYDIMCKVK	SWVIDQKKPV
RFYHDWNDKE	IEVLNKHLFL	TSKPMVYLVN	LSEKDYIRKK	NKWLIKIKEW
VDKYDPGALV	IPFSGALELK	LQELSAEERQ	KYLEANMTQS	ALPKIIKAGF
AALQLEYFFT	AGPDEVRAWT	IRKGTKAPQA	AGKIHTDFEK	GFIMAEVMKY
EDFKEEGSEN	AVKAAGKYRQ	QGRNYIVEDG	DIIFFKFNTP	QQPKKK

Funkcija uredi

Ola1 pripada porodici proteina sličnih Obg GTPazama, ali definira izuzetan primjer proteina koji je evoluirao izmijenjenu nukleotidnu specifičnost i veže adenozin-trifosfat (ATP) s većim afinitetom od gvanozin-trifosfata (GTP).^[5]

Reference uredi

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138430 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027108 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Koller-Eichhorn R, Marquardt T, Gail R, Wittinghofer A, Kostrewa D, Kutay U, Kambach C (Jul 2007). "Human OLA1 defines an ATPase subfamily in the Obg family of GTP-binding proteins". J Biol Chem. 282 (27): 19928–37. doi:10.1074/jbc.M700541200. PMID 17430889.
^ "Entrez Gene: GTPBP9 GTP-binding protein 9 (putative)".
^ "UniProt, Q9NTK5" (jezik: engleski). Pristupljeno 18. 11. 2021.

Dopunska literatura uredi

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Vanjski linkovi uredi

Q9NTK5

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138430 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027108 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid17430889-5] Koller-Eichhorn R, Marquardt T, Gail R, Wittinghofer A, Kostrewa D, Kutay U, Kambach C (Jul 2007). "Human OLA1 defines an ATPase subfamily in the Obg family of GTP-binding proteins". J Biol Chem. 282 (27): 19928–37. doi:10.1074/jbc.M700541200. PMID 17430889.

[entrez-6] "Entrez Gene: GTPBP9 GTP-binding protein 9 (putative)".

[UniProt-7] "UniProt, Q9NTK5" (jezik: engleski). Pristupljeno 18. 11. 2021.

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