NUPR1

Jedarni protein 1 je protein koji je kod ljudi kodiran genom NUPR1.^[5]^[6]^[7]^[8]

NUPR1

Identifikatori

Vanjski ID-jevi

OMIM: 614812 MGI: 1891834 HomoloGene: 8229 GeneCards: NUPR1

Lokacija gena (čovjek)

Hrom.	Hromosom 16 (čovjek)^[1]

Bend	16p11.2	Početak	28,532,708 bp^[1]
Bend	16p11.2	Kraj	28,539,008 bp^[1]

Lokacija gena (miš)

Hrom.	Hromosom 7 (miš)^[2]

Bend	7\|7 F3	Početak	126,222,421 bp^[2]
Bend	7\|7 F3	Kraj	126,230,033 bp^[2]

Obrazac RNK ekspresije

Više referentnih podataka o ekspresiji

Ontologija gena
Molekularna funkcija	• chromatin binding • vezivanje sa DNK • GO:0001948, GO:0016582 vezivanje za proteine • GO:0001105 transcription coactivator activity • acetyltransferase activator activity
Ćelijska komponenta	• jedro • citosol • protein-DNA complex • citoplazma • perinuklearno područje citoplazme
Biološki proces	• skeletal muscle cell differentiation • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • negative regulation of cell cycle • male gonad development • GO:0009373 regulation of transcription, DNA-templated • acute inflammatory response • negative regulation of fibroblast proliferation • regulation of female gonad development • response to toxic substance • transcription, DNA-templated • protein acetylation • positive regulation of protein modification process • positive regulation of apoptotic process • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • Ćelijska proliferacija • GO:0034622 protein-containing complex assembly • negative regulation of cell population proliferation • GO:0048554 positive regulation of catalytic activity • positive regulation of proteasomal protein catabolic process • positive regulation of nucleic acid-templated transcription • regulation of autophagy • negative regulation of autophagy • negative regulation of cardiac muscle cell apoptotic process • negative regulation of apoptotic process • negative regulation of DNA-binding transcription factor activity • positive regulation of neuron apoptotic process • negative regulation of glycolytic process • negative regulation of epithelial cell proliferation • negative regulation of programmed necrotic cell death • positive regulation of neuroinflammatory response • negative regulation of autophagosome assembly • positive regulation of oxidative phosphorylation • negative regulation of epithelial cell apoptotic process • negative regulation of type B pancreatic cell proliferation • regulation of response to endoplasmic reticulum stress • positive regulation of intrinsic apoptotic signaling pathway
Izvori:Amigo / QuickGO

Vrste

Čovjek

Miš


26471


56312


ENSG00000176046


ENSMUSG00000030717


O60356


Q9WTK0

RefSeq (mRNK)


NM_012385 NM_001042483


NM_019738

RefSeq (bjelančevina)


NP_001035948 NP_036517


NP_062712

Lokacija (UCSC)

Chr 16: 28.53 – 28.54 Mb

Chr 7: 126.22 – 126.23 Mb

PubMed pretraga

^[3]

^[4]

Pogledaj/uredi – čovjek

Pogledaj/uredi – miš

Popoću PCR-analize hibridnih ljudskih i glodarkih ćelijai i analizom baza podataka, gen NUPR1 mapiran je na na hromosomu 16, regija 16p11.2.

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 82 aminokiseline, a molekulska težina 8.873 Da.^[9].

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10		20		30		40		50
MATFPPATSA		PQQPPGPEDE		DSSLDESDLY		SLAHSYLGGG		GRKGRTKREA
AANTNRPSPG		GHERKLVTKL		QNSERKKRGA		RR

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000176046 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030717 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mallo GV, Fiedler F, Calvo EL, Ortiz EM, Vasseur S, Keim V, Morisset J, Iovanna JL (Jan 1998). "Cloning and expression of the rat p8 cDNA, a new gene activated in pancreas during the acute phase of pancreatitis, pancreatic development, and regeneration, and which promotes cellular growth". J Biol Chem. 272 (51): 32360–9. doi:10.1074/jbc.272.51.32360. PMID 9405444.
^ Ree AH, Tvermyr M, Engebraaten O, Rooman M, Rosok O, Hovig E, Meza-Zepeda LA, Bruland OS, Fodstad O (Oct 1999). "Expression of a novel factor in human breast cancer cells with metastatic potential". Cancer Res. 59 (18): 4675–80. PMID 10493524.
^ Vasseur S, Vidal Mallo G, Fiedler F, Bodeker H, Canepa E, Moreno S, Iovanna JL (Apr 1999). "Cloning and expression of the human p8, a nuclear protein with mitogenic activity". Eur J Biochem. 259 (3): 670–5. doi:10.1046/j.1432-1327.1999.00092.x. PMID 10092851.
^ "Entrez Gene: NUPR1 nuclear protein 1".
^ "UniProt, O60356". Pristupljeno 8. 7. 2021.

Dopunska literatura

Loftus BJ, Kim UJ, Sneddon VP, et al. (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.
Hoffmeister A, Ropolo A, Vasseur S, et al. (2002). "The HMG-I/Y-related protein p8 binds to p300 and Pax2 trans-activation domain-interacting protein to regulate the trans-activation activity of the Pax2A and Pax2B transcription factors on the glucagon gene promoter". J. Biol. Chem. 277 (25): 22314–9. doi:10.1074/jbc.M201657200. PMID 11940591.
Ree AH, Bratland A, Kroes RA, et al. (2002). "Clinical and cell line specific expression profiles of a human gene identified in experimental central nervous system metastases". Anticancer Res. 22 (4): 1949–57. PMID 12174869.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Jiang WG, Davies G, Fodstad O (2005). "Com-1/P8 in oestrogen regulated growth of breast cancer cells, the ER-beta connection". Biochem. Biophys. Res. Commun. 330 (1): 253–62. doi:10.1016/j.bbrc.2005.02.157. PMID 15781258.
Mao Y, Zhao Y, Zhou LF, et al. (2006). "A novel gene mutation (1292 deletion) in a Chinese family with cerebral cavernous malformations". Neurosurgery. 56 (5): 1149–53, discussion 1149–53. doi:10.1227/01.NEU.0000157967.67963.7A. PMID 15854263. S2CID 6398096.
Ito Y, Yoshida H, Motoo Y, et al. (2005). "Expression of p8 protein in medullary thyroid carcinoma". Anticancer Res. 25 (5): 3419–23. PMID 16101158.
Valacco MP, Varone C, Malicet C, et al. (2006). "Cell growth-dependent subcellular localization of p8". J. Cell. Biochem. 97 (5): 1066–79. doi:10.1002/jcb.20682. PMID 16294328. S2CID 27764122.
Malicet C, Hoffmeister A, Moreno S, et al. (2006). "Interaction of the stress protein p8 with Jab1 is required for Jab1-dependent p27 nuclear-to-cytoplasm translocation". Biochem. Biophys. Res. Commun. 339 (1): 284–9. doi:10.1016/j.bbrc.2005.11.018. PMID 16300740.
Malicet C, Giroux V, Vasseur S, et al. (2006). "Regulation of apoptosis by the p8/prothymosin alpha complex". Proc. Natl. Acad. Sci. U.S.A. 103 (8): 2671–6. doi:10.1073/pnas.0508955103. PMC 1413786. PMID 16478804.
Malicet C, Dagorn JC, Neira JL, Iovanna JL (2006). "p8 and prothymosin alpha: unity is strength". Cell Cycle. 5 (8): 829–30. doi:10.4161/cc.5.8.2686. PMID 16628001.
Jiang WG, Davies G, Martin TA, et al. (2007). "Com-1/p8 acts as a putative tumour suppressor in prostate cancer". Int. J. Mol. Med. 18 (5): 981–6. doi:10.3892/ijmm.18.5.981. PMID 17016631.
Ishida M, Miyamoto M, Naitoh S, et al. (2007). "The SYT-SSX fusion protein down-regulates the cell proliferation regulator COM1 in t(x;18) synovial sarcoma". Mol. Cell. Biol. 27 (4): 1348–55. doi:10.1128/MCB.00658-06. PMC 1800732. PMID 17101797.
Goruppi S, Patten RD, Force T, Kyriakis JM (2007). "Helix-loop-helix protein p8, a transcriptional regulator required for cardiomyocyte hypertrophy and cardiac fibroblast matrix metalloprotease induction". Mol. Cell. Biol. 27 (3): 993–1006. doi:10.1128/MCB.00996-06. PMC 1800682. PMID 17116693.

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