NUPR1

Jedarni protein 1 je protein koji je kod ljudi kodiran genom NUPR1.

NUPR1
Identifikatori
Aliasi	NUPR1
Vanjski ID-jevi	OMIM: 614812 MGI: 1891834 HomoloGene: 8229 GeneCards: NUPR1
Lokacija gena (čovjek) Hrom. Hromosom 16 (čovjek) Bend 16p11.2 Početak 28,532,708 bp Kraj 28,539,008 bp
Lokacija gena (miš) Hrom. Hromosom 7 (miš) Bend 7|7 F3 Početak 126,222,421 bp Kraj 126,230,033 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • chromatin binding • vezivanje sa DNK • GO:0001948, GO:0016582 vezivanje za proteine • GO:0001105 transcription coactivator activity • acetyltransferase activator activity Ćelijska komponenta • jedro • citosol • protein-DNA complex • citoplazma • perinuklearno područje citoplazme Biološki proces • skeletal muscle cell differentiation • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • negative regulation of cell cycle • male gonad development • GO:0009373 regulation of transcription, DNA-templated • acute inflammatory response • negative regulation of fibroblast proliferation • regulation of female gonad development • response to toxic substance • transcription, DNA-templated • protein acetylation • positive regulation of protein modification process • positive regulation of apoptotic process • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • Ćelijska proliferacija • GO:0034622 protein-containing complex assembly • negative regulation of cell population proliferation • GO:0048554 positive regulation of catalytic activity • positive regulation of proteasomal protein catabolic process • positive regulation of nucleic acid-templated transcription • regulation of autophagy • negative regulation of autophagy • negative regulation of cardiac muscle cell apoptotic process • negative regulation of apoptotic process • negative regulation of DNA-binding transcription factor activity • positive regulation of neuron apoptotic process • negative regulation of glycolytic process • negative regulation of epithelial cell proliferation • negative regulation of programmed necrotic cell death • positive regulation of neuroinflammatory response • negative regulation of autophagosome assembly • positive regulation of oxidative phosphorylation • negative regulation of epithelial cell apoptotic process • negative regulation of type B pancreatic cell proliferation • regulation of response to endoplasmic reticulum stress • positive regulation of intrinsic apoptotic signaling pathway Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	26471	56312
Ensembl	ENSG00000176046	ENSMUSG00000030717
UniProt	O60356	Q9WTK0
RefSeq (mRNK)	NM_012385 NM_001042483	NM_019738
RefSeq (bjelančevina)	NP_001035948 NP_036517	NP_062712
Lokacija (UCSC)	Chr 16: 28.53 – 28.54 Mb	Chr 7: 126.22 – 126.23 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Popoću PCR-analize hibridnih ljudskih i glodarkih ćelijai i analizom baza podataka, gen NUPR1 mapiran je na na hromosomu 16, regija 16p11.2.

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 82 aminokiseline, a molekulska težina 8.873 Da..

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10		20		30		40		50
MATFPPATSA		PQQPPGPEDE		DSSLDESDLY		SLAHSYLGGG		GRKGRTKREA
AANTNRPSPG		GHERKLVTKL		QNSERKKRGA		RR

Dopunska literatura

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• Jiang WG, Davies G, Fodstad O (2005). "Com-1/P8 in oestrogen regulated growth of breast cancer cells, the ER-beta connection". Biochem. Biophys. Res. Commun. 330 (1): 253–62. doi:10.1016/j.bbrc.2005.02.157. PMID 15781258.
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• Valacco MP, Varone C, Malicet C, et al. (2006). "Cell growth-dependent subcellular localization of p8". J. Cell. Biochem. 97 (5): 1066–79. doi:10.1002/jcb.20682. PMID 16294328. S2CID 27764122.
• Malicet C, Hoffmeister A, Moreno S, et al. (2006). "Interaction of the stress protein p8 with Jab1 is required for Jab1-dependent p27 nuclear-to-cytoplasm translocation". Biochem. Biophys. Res. Commun. 339 (1): 284–9. doi:10.1016/j.bbrc.2005.11.018. PMID 16300740.
• Malicet C, Giroux V, Vasseur S, et al. (2006). "Regulation of apoptosis by the p8/prothymosin alpha complex". Proc. Natl. Acad. Sci. U.S.A. 103 (8): 2671–6. doi:10.1073/pnas.0508955103. PMC 1413786. PMID 16478804.
• Malicet C, Dagorn JC, Neira JL, Iovanna JL (2006). "p8 and prothymosin alpha: unity is strength". Cell Cycle. 5 (8): 829–30. doi:10.4161/cc.5.8.2686. PMID 16628001.
• Jiang WG, Davies G, Martin TA, et al. (2007). "Com-1/p8 acts as a putative tumour suppressor in prostate cancer". Int. J. Mol. Med. 18 (5): 981–6. doi:10.3892/ijmm.18.5.981. PMID 17016631.
• Ishida M, Miyamoto M, Naitoh S, et al. (2007). "The SYT-SSX fusion protein down-regulates the cell proliferation regulator COM1 in t(x;18) synovial sarcoma". Mol. Cell. Biol. 27 (4): 1348–55. doi:10.1128/MCB.00658-06. PMC 1800732. PMID 17101797.
• Goruppi S, Patten RD, Force T, Kyriakis JM (2007). "Helix-loop-helix protein p8, a transcriptional regulator required for cardiomyocyte hypertrophy and cardiac fibroblast matrix metalloprotease induction". Mol. Cell. Biol. 27 (3): 993–1006. doi:10.1128/MCB.00996-06. PMC 1800682. PMID 17116693.