NUDT3
Difosfoinozitol-polifosfatna fosfohidrolaza 1 jest enzim koji je kod ljudi kodiran genom NUDT3.[5][6]
Aminokiselinska sekvenca uredi
Dužina polipeptidnog lanca je 172 aminokiseline, а molekulska težina 19.471 Da.[7].
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MMKLKSNQTR | TYDGDGYKKR | AACLCFRSES | EEEVLLVSSS | RHPDRWIVPG | ||||
| GGMEPEEEPS | VAAVREVCEE | AGVKGTLGRL | VGIFENQERK | HRTYVYVLIV | ||||
| TEVLEDWEDS | VNIGRKREWF | KIEDAIKVLQ | YHKPVQASYF | ETLRQGYSAN | ||||
| NGTPVVATTY | SVSAQSSMSG | IR |
Funkcija uredi
NUDT3 pripada porodici proteina MutT, ili Nudix. Proteini Nudix djeluju kao homeostatske kontrolne tsčke u važnim fazama metaboličkih puteva nukleozid fosfata, štiteći od povišenih razina potencijalno opasnih međuprodukata, poput 8-okso-dGTP, koji podstiče transverzije AT-u-CG (Safrany et al., 1998, prema OMIMu)[6]
Reference uredi
- ^ a b c GRCh38: Ensembl release 89: ENSG00000272325 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024213 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Safrany ST, Caffrey JJ, Yang X, Bembenek ME, Moyer MB, Burkhart WA, Shears SB (Jan 1999). "A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase". EMBO J. 17 (22): 6599–607. doi:10.1093/emboj/17.22.6599. PMC 1171006. PMID 9822604.
- ^ a b "Entrez Gene: NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3".
- ^ "UniProt, O95989" (jezik: engleski). Pristupljeno 4. 10. 2021.
Dopunska literatura uredi
- Safrany ST, Ingram SW, Cartwright JL, et al. (1999). "The diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase. Overlapping substrate specificities in a MutT-type protein". J. Biol. Chem. 274 (31): 21735–40. doi:10.1074/jbc.274.31.21735. PMID 10419486.
- Yang X, Safrany ST, Shears SB (2000). "Site-directed mutagenesis of diphosphoinositol polyphosphate phosphohydrolase, a dual specificity NUDT enzyme that attacks diadenosine polyphosphates and diphosphoinositol polyphosphates". J. Biol. Chem. 274 (50): 35434–40. doi:10.1074/jbc.274.50.35434. PMID 10585413.
- Fisher DI, Safrany ST, Strike P, et al. (2003). "Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the glycolytic activator ribose 1,5-bisphosphate". J. Biol. Chem. 277 (49): 47313–7. doi:10.1074/jbc.M209795200. PMID 12370170.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.