Čvorovski modulator 1 je protein koji je kod ljudi kodiran genom NOMO1 .[ 5] [ 6] [ 7]
Ovaj gen kodira protein za koji se prvobitno mislilo da je povezan sa porodicom gena kolagenaza . Jedan je od tri vrlo slična gena u regiji duplikacije na p kraku hromosoma 16 . Ova tri gena kodiraju blisko povezane proteine koji mogu imati istu funkciju. Protein kodiran jednim od ovih gena identificiran je kao dio proteinskog kompleksa koji učestvuje u signalnom putu čvorova tokom razvoja kičmenjaka . Mutacije u ABCC6, koje se nalazi u blizini, umjesto mutacije ovog gena povezane su sa pseudoxanthoma elasticum [ 7]
Aminokiselinska sekvenca
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Dužina polipeptidnog lanca je 1.222 aminokiseline , a molekulska težina 134.324 Da [ 8]
Simboli
10 20 30 40 50 MLVGQGAGPL GPAVVTAAVV LLLSGVGPAH GSEDIVVGCG GFVKSDVEIN YSLIEIKLYT KHGTLKYQTD CAPNNGYFMI PLYDKGDFIL KIEPPLGWSF EPTTVELHVD GVSDICTKGG DINFVFTGFS VNGKVLSKGQ PLGPAGVQVS LRNTGTEAKI QSTVTQPGGK FAFFKVLPGD YEILATHPTW ALKEASTTVR VTNSNANAAS PLIVAGYNVS GSVRSDGEPM KGVKFLLFSS LVTKEDVLGC NVSPVPGFQP QDESLVYLCY TVSREDGSFS FYSLPSGGYT VIPFYRGERI TFDVAPSRLD FTVEHDSLKI EPVFHVMGFS VTGRVLNGPE GDGVPEAVVT LNNQIKVKTK ADGSFRLENI TTGTYTIHAQ KEHLYFETVT IKIAPNTPQL ADIIATGFSV CGQISIIRFP DTVKQMNKYK VVLSSQDKDK SLVTVETDAH GSFCFKAKPG TYKVQVMVPE AETRAGLTLK PQTFPLTVTN RPMMDVAFVQ FLASVSGKVS CLDTCGDLLV TLQSLSRQGE KRSLQLSGKV NAMTFTFDNV LPGKYKISIM HEDWCWKNKS LEVEVLEDDM SAVEFRQTGY MLRCSLSHAI TLEFYQDGNG RENVGIYNLS KGVNRFCLSK PGVYKVTPRS CHRFEQAFYT YDTSSPSILT LTAIRHHVLG TITTDKMMDV TVTIKSSIDS EPALVLGPLK SVQELRREQQ LAEIEARRQE REKNGNEEGE ERMTKPPVQE MVDELQGPFS YDFSYWARSG EKITVTPSSK ELLFYPPSME AVVSGESCPG KLIEIHGKAG LFLEGQIHPE LEGVEIVISE KGASSPLITV FTDDKGAYSV GPLHSDLEYT VTSQKEGYVL TAVEGTIGDF KAYALAGVSF EIKAEDDQPL PGVLLSLSGG LFRSNLLTQD NGILTFSNLS PGQYYFKPMM KEFRFEPSSQ MIEVQEGQNL KITITGYRTA YSCYGTVSSL NGEPEQGVAM EAVGQNDCSI YGEDTVTDEE GKFRLRGLLP GCVYHVQLKA EGNDHIERAL PHHRVIEVGN NDIDDVNIIV FRQINQFDLS GNVITSSEYL PTLWVKLYKS ENLDNPIQTV SLGQSLFFHF PPLLRDGENY VVLLDSTLPR SQYDYILPQV SFTAVGYHKH ITLIFNPTRK LPEQDIAQGS YIALPLTLLV LLAGYNHDKL IPLLLQLTSR LQGVRALGQA ASDNSGPEDA KRQAKKQKTR RT
^ a b c GRCh38: Ensembl release 89: ENSG00000103512 - Ensembl , maj 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030835 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Templeton NS, Rodgers LA, Levy AT, Ting KL, Krutzsch HC, Liotta LA, Stetler-Stevenson WG (Mar 1992). "Cloning and characterization of a novel human cDNA that has DNA similarity to the conserved region of the collagenase gene family" . Genomics . 12 (1): 175–6. doi :10.1016/0888-7543(92)90425-R . PMID 1310294 . ^ Haffner C, Frauli M, Topp S, Irmler M, Hofmann K, Regula JT, Bally-Cuif L, Haass C (Aug 2004). "Nicalin and its binding partner Nomo are novel Nodal signaling antagonists" . EMBO J . 23 (15): 3041–50. doi :10.1038/sj.emboj.7600307 . PMC 514924 PMID 15257293 . ^ a b "Entrez Gene: NOMO1 NODAL modulator 1" .^ "UniProt, Q15155" . Pristupljeno 8. 7. 2021 .
Dopunska literatura
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Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration" . Cell . 125 (4): 801–14. doi :10.1016/j.cell.2006.03.032 PMID 16713569 . S2CID 13709685 . Pope SN, Lee IR (2005). "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin". J. Steroid Biochem. Mol. Biol . 94 (1–3): 203–8. doi :10.1016/j.jsbmb.2005.01.007 . PMID 15862967 . S2CID 9746088 . Martin J, Han C, Gordon LA, et al. (2005). "The sequence and analysis of duplication-rich human chromosome 16" . Nature . 432 (7020): 988–94. doi :10.1038/nature03187 PMID 15616553 . Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway" . Genome Res . 14 (7): 1324–32. doi :10.1101/gr.2334104 . PMC 442148 PMID 15231748 . Lehner B, Sanderson CM (2004). "A Protein Interaction Framework for Human mRNA Degradation" . Genome Res . 14 (7): 1315–23. doi :10.1101/gr.2122004 . PMC 442147 PMID 15231747 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 . PMC 139241 PMID 12477932 . Loftus BJ, Kim UJ, Sneddon VP, et al. (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics . 60 (3): 295–308. doi :10.1006/geno.1999.5927 . PMID 10493829 . van Soest S, Swart J, Tijmes N, et al. (1997). "A Locus for Autosomal Recessive Pseudoxanthoma Elasticum, with Penetrance of Vascular Symptoms in Carriers, Maps to Chromosome 16p13.1" . Genome Res . 7 (8): 830–4. doi :10.1101/gr.7.8.830 . PMC 310666 PMID 9267806 . Matoba R, Okubo K, Hori N, et al. (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression" . Gene . 146 (2): 199–207. doi :10.1016/0378-1119(94)90293-3 . PMID 8076819 . 
