CHRNA2

CHRNA2
Identifikatori
Aliasi	CHRNA2
Vanjski ID-jevi	OMIM: 118502 MGI: 87886 HomoloGene: 20193 GeneCards: CHRNA2
Lokacija gena (čovjek)
Hrom.	Hromosom 8 (čovjek)
Kraj	27,479,883 bp
Lokacija gena (miš)
Hrom.	Hromosom 14 (miš)
Kraj	66,390,397 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• acetylcholine binding; • acetylcholine receptor activity; • ion channel activity; • extracellular ligand-gated ion channel activity; • ligand-gated ion channel activity; • acetylcholine-gated cation-selective channel activity; • transmembrane signaling receptor activity;
Ćelijska komponenta	• integral component of membrane; • acetylcholine-gated channel complex; • postsynaptic membrane; • membrana; • ćelijska membrana; • sinapsa; • međućelijske veze; • cell periphery; • integral component of plasma membrane; • neuron projection;
Biološki proces	• protein heterooligomerization; • response to nicotine; • synaptic transmission, cholinergic; • ion transport; • neuromuscular synaptic transmission; • GO:0072468 Transdukcija signala; • regulation of postsynaptic membrane potential; • excitatory postsynaptic potential; • ion transmembrane transport; • chemical synaptic transmission; • regulation of membrane potential; • nervous system process; • transmembrane transport;
	Izvori:Amigo / QuickGO
Ortolozi
	1135
	110902
	ENSG00000120903
	ENSMUSG00000022041
	Q15822
	Q91X60
NM_000742; NM_001282455; NM_001347705; NM_001347706; NM_001347707;
	NM_001347708
	NM_144803
NP_000733; NP_001269384; NP_001334634; NP_001334635; NP_001334636;
	NP_001334637
	NP_659052
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Podjedinica alfa-2 receptora neuronskog acetilholina, znana i kao nAChRα2, je protein koji je kod ljudi kodiran genom CHRNA2.^[5]^[6] Protein kodiran ovim genom podjedinica je nekih nikotinskih acetilholinskih receptora (nAchR).

Aminokiselinska sekvenca uredi

Dužina polipeptidnog lanca je 529 aminokiselina, а molekulska težina 59.765 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MGPSCPVFLS	FTKLSLWWLL	LTPAGGEEAK	RPPPRAPGDP	LSSPSPTALP
QGGSHTETED	RLFKHLFRGY	NRWARPVPNT	SDVVIVRFGL	SIAQLIDVDE
KNQMMTTNVW	LKQEWSDYKL	RWNPTDFGNI	TSLRVPSEMI	WIPDIVLYNN
ADGEFAVTHM	TKAHLFSTGT	VHWVPPAIYK	SSCSIDVTFF	PFDQQNCKMK
FGSWTYDKAK	IDLEQMEQTV	DLKDYWESGE	WAIVNATGTY	NSKKYDCCAE
IYPDVTYAFV	IRRLPLFYTI	NLIIPCLLIS	CLTVLVFYLP	SDCGEKITLC
ISVLLSLTVF	LLLITEIIPS	TSLVIPLIGE	YLLFTMIFVT	LSIVITVFVL
NVHHRSPSTH	TMPHWVRGAL	LGCVPRWLLM	NRPPPPVELC	HPLRLKLSPS
YHWLESNVDA	EEREVVVEEE	DRWACAGHVA	PSVGTLCSHG	HLHSGASGPK
AEALLQEGEL	LLSPHMQKAL	EGVHYIADHL	RSEDADSSVK	EDWKYVAMVI
DRIFLWLFII	VCFLGTIGLF	LPPFLAGMI

Funkcija uredi

Nokaut ovog mišjeg gena potencira nikotinski modulirana ponašanja.^[8] Upotrebom dvije različite genetički modificirane mišje mutantne linije (Chrna2L9'S/L9'S i Chrna2KO), nalazi su upozorili da α2* nAChR-ovi utiču na hipokampusno ovisno učenje, pamćenje i sinapsnu plastičnost kod adolescentnih miševa.^[9]

Također pogledajte uredi

Receptor nikotin-acetilholina

Reference uredi

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000120903 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022041 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Anand R, Lindstrom J (Sep 1992). "Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans". Genomics. 13 (4): 962–7. doi:10.1016/0888-7543(92)90008-G. PMID 1505988.
^ "Entrez Gene: CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)".
^ "UniProt, Q15822" (jezik: engleski). Pristupljeno 15. 9. 2021.
^ Lotfipour S, Byun JS, Leach P, Fowler CD, Murphy NP, Kenny PJ, Gould TJ, Boulter J (maj 2013). "Targeted Deletion of the Mouse α2 Nicotinic Acetylcholine Receptor Subunit Gene (Chrna2) Potentiates Nicotine-Modulated Behaviors". J. Neurosci. 33 (18): 7728–41. doi:10.1523/JNEUROSCI.4731-12.2013. PMC 3831006. PMID 23637165.
^ Lotfipour S, Mojica C, Nakauchi S, Lipovsek M, Silverstein S, Cushman J, Tirtorahardjo J, Poulos A, Elgoyhen AB, Sumikawa K, Fanselow MS, Boulter J (maj 2017). "α2* Nicotinic acetylcholine receptors influence hippocampus-dependent learning and memory in adolescent mice". Learn Mem. 24 (6): 231–244. doi:10.1101/lm.045369.117. PMC 5435881. PMID 28507032.

Dopunska literatura uredi

Hogg RC, Raggenbass M, Bertrand D (2003). "Nicotinic acetylcholine receptors: from structure to brain function". Rev. Physiol. Biochem. Pharmacol. Reviews of Physiology, Biochemistry and Pharmacology. 147: 1–46. doi:10.1007/s10254-003-0005-1. ISBN 978-3-540-01365-5. PMID 12783266.
Wood S, Schertzer M, Yaremko ML (1995). "Identification of the human neuronal nicotinic cholinergic alpha 2 receptor locus, (CHRNA2), within an 8p21 mapped locus, by sequence homology with rat DNA". Somat. Cell Mol. Genet. 21 (2): 147–50. doi:10.1007/BF02255790. PMID 7570187. S2CID 28611125.
García-Colunga J, Miledi R (1995). "Effects of serotonergic agents on neuronal nicotinic acetylcholine receptors". Proc. Natl. Acad. Sci. U.S.A. 92 (7): 2919–23. Bibcode:1995PNAS...92.2919G. doi:10.1073/pnas.92.7.2919. PMC 42330. PMID 7708749.
Elliott KJ, Ellis SB, Berckhan KJ, et al. (1997). "Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits". J. Mol. Neurosci. 7 (3): 217–28. doi:10.1007/BF02736842. PMID 8906617. S2CID 45737923.
Chavez-Noriega LE, Crona JH, Washburn MS, et al. (1997). "Pharmacological characterization of recombinant human neuronal nicotinic acetylcholine receptors h alpha 2 beta 2, h alpha 2 beta 4, h alpha 3 beta 2, h alpha 3 beta 4, h alpha 4 beta 2, h alpha 4 beta 4 and h alpha 7 expressed in Xenopus oocytes". J. Pharmacol. Exp. Ther. 280 (1): 346–56. PMID 8996215.
Navaneetham D, Penn A, Howard J, Conti-Fine BM (1997). "Expression of the alpha 7 subunit of the nicotinic acetylcholine receptor in normal and myasthenic human thymuses". Cell. Mol. Biol. (Noisy-le-grand). 43 (3): 433–42. PMID 9193799.
Sato KZ, Fujii T, Watanabe Y, et al. (1999). "Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines". Neurosci. Lett. 266 (1): 17–20. doi:10.1016/S0304-3940(99)00259-1. PMID 10336173. S2CID 43548155.
Bertrand D, Picard F, Le Hellard S, et al. (2002). "How mutations in the nAChRs can cause ADNFLE epilepsy". Epilepsia. 43 Suppl 5: 112–22. doi:10.1046/j.1528-1157.43.s.5.16.x. PMID 12121305. S2CID 32858402.
Jin P, Fu GK, Wilson AD, et al. (2004). "PCR isolation and cloning of novel splice variant mRNAs from known drug target genes". Genomics. 83 (4): 566–71. doi:10.1016/j.ygeno.2003.09.023. PMID 15028279.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Nusbaum C, Mikkelsen TS, Zody MC, et al. (2006). "DNA sequence and analysis of human chromosome 8". Nature. 439 (7074): 331–5. Bibcode:2006Natur.439..331N. doi:10.1038/nature04406. PMID 16421571.
Aridon P, Marini C, Di Resta C, et al. (2006). "Increased Sensitivity of the Neuronal Nicotinic Receptor α2 Subunit Causes Familial Epilepsy with Nocturnal Wandering and Ictal Fear". Am. J. Hum. Genet. 79 (2): 342–50. doi:10.1086/506459. PMC 1559502. PMID 16826524.

Vanjski linkovi uredi

CHRNA2 protein, human na US National Library of Medicine Medical Subject Headings (MeSH)
Lokacija ljudskog genoma CHRNA2 i stranica sa detaljima o genu CHRNA2 u UCSC Genome Browseru.

Šablon:Ligandski ionski kanali

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000120903 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022041 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1505988-5] Anand R, Lindstrom J (Sep 1992). "Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans". Genomics. 13 (4): 962–7. doi:10.1016/0888-7543(92)90008-G. PMID 1505988.

[entrez-6] "Entrez Gene: CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)".

[UniProt-7] "UniProt, Q15822" (jezik: engleski). Pristupljeno 15. 9. 2021.

[pmid23637165-8] Lotfipour S, Byun JS, Leach P, Fowler CD, Murphy NP, Kenny PJ, Gould TJ, Boulter J (maj 2013). "Targeted Deletion of the Mouse α2 Nicotinic Acetylcholine Receptor Subunit Gene (Chrna2) Potentiates Nicotine-Modulated Behaviors". J. Neurosci. 33 (18): 7728–41. doi:10.1523/JNEUROSCI.4731-12.2013. PMC 3831006. PMID 23637165.

[pmid28507032-9] Lotfipour S, Mojica C, Nakauchi S, Lipovsek M, Silverstein S, Cushman J, Tirtorahardjo J, Poulos A, Elgoyhen AB, Sumikawa K, Fanselow MS, Boulter J (maj 2017). "α2* Nicotinic acetylcholine receptors influence hippocampus-dependent learning and memory in adolescent mice". Learn Mem. 24 (6): 231–244. doi:10.1101/lm.045369.117. PMC 5435881. PMID 28507032.

[5]

[6]

[1]

[2]

[3]

[4]

[7]

[8]

[9]