MAN1A2
Mannozil-oligosaharidna 1,2-alfa-manozidaza IB jest enzim koji je kod ljudi kodiran genom MAN1A2 sa hromosoma 1.[5][6]
Aminokiselinska sekvenca
urediDužina polipeptidnog lanca je 641 aminokiselina, a molekulska težina 73.004 Da. [7]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MTTPALLPLS | GRRIPPLNLG | PPSFPHHRAT | LRLSEKFILL | LILSAFITLC | ||||
| FGAFFFLPDS | SKHKRFDLGL | EDVLIPHVDA | GKGAKNPGVF | LIHGPDEHRH | ||||
| REEEERLRNK | IRADHEKALE | EAKEKLRKSR | EEIRAEIQTE | KNKVVQEMKI | ||||
| KENKPLPPVP | IPNLVGIRGG | DPEDNDIREK | REKIKEMMKH | AWDNYRTYGW | ||||
| GHNELRPIAR | KGHSPNIFGS | SQMGATIVDA | LDTLYIMGLH | DEFLDGQRWI | ||||
| EDNLDFSVNS | EVSVFEVNIR | FIGGLLAAYY | LSGEEIFKIK | AVQLAEKLLP | ||||
| AFNTPTGIPW | AMVNLKSGVG | RNWGWASAGS | SILAEFGTLH | MEFIHLSYLT | ||||
| GDLTYYKKVM | HIRKLLQKMD | RPNGLYPNYL | NPRTGRWGQY | HTSVGGLGDS | ||||
| FYEYLLKAWL | MSDKTDHEAR | KMYDDAIEAI | EKHLIKKSRG | GLTFIGEWKN | ||||
| GHLEKKMGHL | ACFAGGMFAL | GADGSRADKA | GHYLELGAEI | ARTCHESYDR | ||||
| TALKLGPESF | KFDGAVEAVA | VRQAEKYYIL | RPEVIETYWY | LWRFTHDPRY | ||||
| RQWGWEAALA | IEKYCRVNGG | FSGVKDVYSS | TPTHDDVQQS | FFLAETLKYL | ||||
| YLLFSGDDLL | PLDHWVFNTE | AHPLPVLHLA | NTTLSGNPAV | R |
Reference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000198162 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000008763 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Tremblay LO, Campbell Dyke N, Herscovics A (Jul 1998). "Molecular cloning, chromosomal mapping and tissue-specific expression of a novel human alpha1,2-mannosidase gene involved in N-glycan maturation". Glycobiology. 8 (6): 585–595. doi:10.1093/glycob/8.6.585. PMID 9592125.
- ^ "Entrez Gene: MAN1A2 mannosidase, alpha, class 1A, member 2".
- ^ "UniProt, O60476" (jezik: eng.). Pristupljeno 30. 11. 2021.CS1 održavanje: nepoznati jezik (link)
Dopunska literatura
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- Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–321. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
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- Fenouillet E, Jones I, Powell B, et al. (1993). "Functional role of the glycan cluster of the human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain". J. Virol. 67 (1): 150–160. doi:10.1128/jvi.67.1.150-160.1993. PMC 237347. PMID 8093218.
- Montefiori DC, Robinson WE, Mitchell WM (1988). "Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1". Proc. Natl. Acad. Sci. U.S.A. 85 (23): 9248–9252. Bibcode:1988PNAS...85.9248M. doi:10.1073/pnas.85.23.9248. PMC 282716. PMID 3264072.
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