Lizofosfatidilholin-aciltransferaza 1 jest protein/enzim koji je kod ljudi kodiran genom LPCAT1 sa hromosoma 5.[5]

LPCAT1
Identifikatori
AliasiLPCAT1
Vanjski ID-jeviOMIM: 610472 MGI: 2384812 HomoloGene: 9871 GeneCards: LPCAT1
EC broj2.3.1.67
Lokacija gena (čovjek)
Hromosom 5 (čovjek)
Hrom.Hromosom 5 (čovjek)[1]
Hromosom 5 (čovjek)
Genomska lokacija za LPCAT1
Genomska lokacija za LPCAT1
Bend5p15.33Početak1,456,480 bp[1]
Kraj1,523,962 bp[1]
Lokacija gena (miš)
Hromosom 13 (miš)
Hrom.Hromosom 13 (miš)[2]
Hromosom 13 (miš)
Genomska lokacija za LPCAT1
Genomska lokacija za LPCAT1
Bend13|13 C1Početak73,615,316 bp[2]
Kraj73,664,541 bp[2]
Ontologija gena
Molekularna funkcija 1-alkylglycerophosphocholine O-acyltransferase activity
vezivanje iona metala
calcium ion binding
aktivnost sa transferazom
acyltransferase activity
1-alkylglycerophosphocholine O-acetyltransferase activity
1-alkenylglycerophosphocholine O-acyltransferase activity
1-acylglycerophosphocholine O-acyltransferase activity
1-acylglycerol-3-phosphate O-acyltransferase activity
2-acylglycerol-3-phosphate O-acyltransferase activity
Ćelijska komponenta integral component of membrane
Golđijev aparat
Golđijeva membrana
membrana
Lipidna kapljica
endoplasmic reticulum membrane
Endoplazmatski retikulum
ćelijska membrana
azurophil granule membrane
Biološki proces phospholipid biosynthetic process
retina development in camera-type eye
lipid metabolism
phosphatidylglycerol acyl-chain remodeling
GO:1903364 positive regulation of protein catabolic process
phosphatidic acid biosynthetic process
metabolizam
surfactant homeostasis
negative regulation of phosphatidylcholine biosynthetic process
phosphatidylcholine acyl-chain remodeling
phospholipid metabolic process
phosphatidylcholine biosynthetic process
neutrophil degranulation
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_024830

NM_145376
NM_001368681
NM_001368682

RefSeq (bjelančevina)

NP_079106

NP_663351
NP_001355610
NP_001355611

Lokacija (UCSC)Chr 5: 1.46 – 1.52 MbChr 13: 73.62 – 73.66 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

uredi

Dužina polipeptidnog lanca je aminokiselina, а molekulska težina 59.151 Da.[6]

1020304050
MRLRGCGPRAAPASSAGASDARLLAPPGRNPFVHELRLSALQKAQVALMT
LTLFPVRLLVAAAMMLLAWPLALVASLGSAEKEPEQPPALWRKVVDFLLK
AIMRTMWFAGGFHRVAVKGRQALPTEAAILTLAPHSSYFDAIPVTMTMSS
IVMKAESRDIPIWGTLIQYIRPVFVSRSDQDSRRKTVEEIKRRAQSNGKW
PQIMIFPEGTCTNRTCLITFKPGAFIPGAPVQPVVLRYPNKLDTITWTWQ
GPGALEILWLTLCQFHNQVEIEFLPVYSPSEEEKRNPALYASNVRRVMAE
ALGVSVTDYTFEDCQLALAEGQLRLPADTCLLEFARLVRGLGLKPEKLEK
DLDRYSERARMKGGEKIGIAEFAASLEVPVSDLLEDMFSLFDESGSGEVD
LRECVVALSVVCRPARTLDTIQLAFKMYGAQEDGSVGEGDLSCILKTALG
VAELTVTDLFRAIDQEEKGKITFADFHRFAEMYPAFAEEYLYPDQTHFES
CAETSPAPIPNGFCADFSPENSDAGRKPVRKKLD

Funkcija

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Lizofosfatidilholin (LPC) aciltransferaza (LPCAT; EC 2.3.1.23) katalizira pretvorbu LPC u fosfatidilholin (PC) na putu remodeliranja biosinteze PC-a.[7]

Reference

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  1. ^ a b c ENSG00000153395 GRCh38: Ensembl release 89: ENSG00000275079, ENSG00000153395 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021608 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Lysophosphatidylcholine acyltransferase 1".
  6. ^ "UniProt, Q8NF37" (jezik: engleski). Pristupljeno 16. 10. 2021.
  7. ^ Nakanishi H, Shindou H, Hishikawa D, Harayama T, Ogasawara R, Suwabe A, Taguchi R, Shimizu T (2006). "Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1). Expression in alveolar type II cells and possible involvement in surfactant production". J. Biol. Chem. 281 (29): 20140–7. doi:10.1074/jbc.M600225200. PMID 16704971.

Vanjski linkovi

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Šablon:PAF signalizacija