LIMD1

Protein 1 sa LIM domenom jest protein koji je kod ljudi kodiran genom LIMD1 sa hromosoma 3.

LIMD1
Identifikatori
Aliasi	LIMD1
Vanjski ID-jevi	OMIM: 604543 MGI: 1352502 HomoloGene: 8478 GeneCards: LIMD1
Lokacija gena (čovjek) Hrom. Hromosom 3 (čovjek) Bend 3p21.31 Početak 45,555,394 bp Kraj 45,686,341 bp
Lokacija gena (miš) Hrom. Hromosom 9 (miš) Bend 9 F4|9 74.0 cM Početak 123,307,771 bp Kraj 123,350,617 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • vezivanje iona metala • GO:0001948, GO:0016582 vezivanje za proteine • GO:0001106 transcription corepressor activity • vezivanje iona cinka Ćelijska komponenta • citoplazma • RNK-inducirani kompleks utišavanja • focal adhesion • adherens junction • P-tijelo • međućelijske veze • jedro • transcription regulator complex • citosol • ćelijska membrana • cell-cell junction Biološki proces • response to hypoxia • GO:0009373 regulation of transcription, DNA-templated • Fosforilacija • negative regulation of osteoblast differentiation • transcription, DNA-templated • GO:1905618 positive regulation of gene silencing by miRNA • multicellular organism development • negative regulation of hippo signaling • gene silencing by miRNA • cytoskeleton organization • P-body assembly • regulation of cell shape • osteoblast development • Utišavanje gena • GO:0045996 negative regulation of transcription, DNA-templated • Ćelijska migracija • negative regulation of canonical Wnt signaling pathway • GO:0072468 Transdukcija signala • regulation of transcription from RNA polymerase II promoter in response to hypoxia Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	8994	29806
Ensembl	ENSG00000144791	ENSMUSG00000025239
UniProt	Q9UGP4	Q9QXD8
RefSeq (mRNK)	NM_014240	NM_013860
RefSeq (bjelančevina)	NP_055055	NP_038888
Lokacija (UCSC)	Chr 3: 45.56 – 45.69 Mb	Chr 9: 123.31 – 123.35 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 676 aminokiselina, а molekulska težina 72.190 Da.

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MDKYDDLGLE		ASKFIEDLNM		YEASKDGLFR		VDKGAGNNPE		FEETRRVFAT
KMAKIHLQQQ		QQQLLQEETL		PRGSRGPVNG		GGRLGPQARW		EVVGSKLTVD
GAAKPPLAAS		TGAPGAVTTL		AAGQPPYPPQ		EQRSRPYLHG		TRHGSQDCGS
RESLATSEMS		AFHQPGPCED		PSCLTHGDYY		DNLSLASPKW		GDKPGVSPSI
GLSVGSGWPS		SPGSDPPLPK		PCGDHPLNHR		QLSLSSSRSS		EGSLGGQNSG
IGGRSSEKPT		GLWSTASSQR		VSPGLPSPNL		ENGAPAVGPV		QPRTPSVSAP
LALSCPRQGG		LPRSNSGLGG		EVSGVMSKPN		VDPQPWFQDG		PKSYLSSSAP
SSSPAGLDGS		QQGAVPGLGP		KPGCTDLGTG		PKLSPTSLVH		PVMSTLPELS
CKEGPLGWSS		DGSLGSVLLD		SPSSPRVRLP		CQPLVPGPEL		RPSAAELKLE
ALTQRLEREM		DAHPKADYFG		ACVKCSKGVF		GAGQACQAMG		NLYHDTCFTC
AACSRKLRGK		AFYFVNGKVF		CEEDFLYSGF		QQSADRCFLC		GHLIMDMILQ
ALGKSYHPGC		FRCVICNECL		DGVPFTVDSE		NKIYCVRDYH		KVLAPKCAAC
GLPILPPEGS		DETIRVVSMD		RDYHVECYHC		EDCGLELNDE		DGHRCYPLED
HLFCHSCHVK		RLEKRPSSTA		LHQHHF

Dopunska literatura

• Jiang T, Altman S (2001). "Protein-protein interactions with subunits of human nuclear RNase P." Proc. Natl. Acad. Sci. U.S.A. 98 (3): 920–5. doi:10.1073/pnas.021561498. PMC 14685. PMID 11158571.
• Kiss H, Kedra D, Kiss C, et al. (2001). "The LZTFL1 gene is a part of a transcriptional map covering 250 kb within the common eliminated region 1 (C3CER1) in 3p21.3". Genomics. 73 (1): 10–9. doi:10.1006/geno.2000.6498. PMID 11352561.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Sharp TV, Munoz F, Bourboulia D, et al. (2004). "LIM domains-containing protein 1 (LIMD1), a tumor suppressor encoded at chromosome 3p21.3, binds pRB and represses E2F-driven transcription". Proc. Natl. Acad. Sci. U.S.A. 101 (47): 16531–6. doi:10.1073/pnas.0407123101. PMC 534532. PMID 15542589.
• Feng Y, Longmore GD (2005). "The LIM protein Ajuba influences interleukin-1-induced NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex". Mol. Cell. Biol. 25 (10): 4010–22. doi:10.1128/MCB.25.10.4010-4022.2005. PMC 1087715. PMID 15870274.
• Huggins CJ, Gill M, Andrulis IL (2007). "Identification of rare variants in the hLIMD1 gene in breast cancer". Cancer Genet. Cytogenet. 178 (1): 36–41. doi:10.1016/j.cancergencyto.2007.06.007. PMID 17889706.