KIF1B

KIF1B
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2EH0
Identifikatori
Aliasi	KIF1B
Vanjski ID-jevi	OMIM: 605995 MGI: 108426 HomoloGene: 99835 GeneCards: KIF1B
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	10,381,603 bp
Lokacija gena (miš)
Hrom.	Hromosom 4 (miš)
Kraj	149,392,150 bp
Ontologija gena
Molekularna funkcija	• microtubule motor activity; • nucleotide binding; • microtubule binding; • ATPase activity; • GO:0001948, GO:0016582 vezivanje za proteine; • kinesin binding; • ATP binding; • kinase binding; • scaffold protein binding; • plus-end-directed microtubule motor activity;
Ćelijska komponenta	• citoplazma; • Kinezin; • microtubule associated complex; • mitohondrija; • neuron projection; • Mikrotubula; • citoskelet; • cytoplasmic vesicle membrane; • GO:0016023 citoplazmatska vezikula; • axon cytoplasm; • membrana; • Akson; • dendrit;
Biološki proces	• cytoskeleton-dependent intracellular transport; • neuron-neuron synaptic transmission; • anterograde axonal transport; • microtubule-based movement; • neuromuscular synaptic transmission; • mitochondrion transport along microtubule; • GO:0097285 apoptoza; • GO:1901313 positive regulation of gene expression; • transport along microtubule; • lysosome localization; • response to rotenone; • cellular response to nerve growth factor stimulus; • protein localization to cell periphery; • anterograde neuronal dense core vesicle transport; • retrograde neuronal dense core vesicle transport; • vesicle-mediated transport;
	Izvori:Amigo / QuickGO
Ortolozi
	23095
	16561
	ENSG00000054523
	ENSMUSG00000063077
	O60333
	Q60575
	NM_183416; NM_015074; NM_001365951; NM_001365952; NM_001365953
	NM_001290995; NM_008441; NM_207682
	NP_055889; NP_904325; NP_001352880; NP_001352881; NP_001352882
	NP_001277924; NP_032467; NP_997565
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Kinezinoliki protein KIF1B jest protein koji je kod ljudi kodiran genom KIF1B sa hromosoma 1.^[5]^[6]^[7]

Aminokiselinska sekvenca uredi

Dužina polipeptidnog lanca je 1.816 aminokiselina, a molekulska težina 204.476 Da.^[8].

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MSGASVKVAV	RVRPFNSRET	SKESKCIIQM	QGNSTSIINP	KNPKEAPKSF
SFDYSYWSHT	SPEDPCFASQ	NRVYNDIGKE	MLLHAFEGYN	VCIFAYGQTG
AGKSYTMMGK	QEESQAGIIP	QLCEELFEKI	NDNCNEEMSY	SVEVSYMEIY
CERVRDLLNP	KNKGNLRVRE	HPLLGPYVED	LSKLAVTSYT	DIADLMDAGN
KARTVAATNM	NETSSRSHAV	FTIVFTQKKH	DNETNLSTEK	VSKISLVDLA
GSERADSTGA	KGTRLKEGAN	INKSLTTLGK	VISALAEVDN	CTSKSKKKKK
TDFIPYRDSV	LTWLLRENLG	GNSRTAMVAA	LSPADINYDE	TLSTLRYADR
AKQIKCNAVI	NEDPNAKLVR	ELKEEVTRLK	DLLRAQGLGD	IIDIDPLIDD
YSGSGSKYLK	DFQNNKHRYL	LASENQRPGH	FSTASMGSLT	SSPSSCSLSS
QVGLTSVTSI	QERIMSTPGG	EEAIERLKES	EKIIAELNET	WEEKLRKTEA
IRMEREALLA	EMGVAIREDG	GTLGVFSPKK	TPHLVNLNED	PLMSECLLYY
IKDGITRVGQ	ADAERRQDIV	LSGAHIKEEH	CIFRSERSNS	GEVIVTLEPC
ERSETYVNGK	RVSQPVQLRS	GNRIIMGKNH	VFRFNHPEQA	RAEREKTPSA
ETPSEPVDWT	FAQRELLEKQ	GIDMKQEMEK	RLQEMEILYK	KEKEEADLLL
EQQRLDYESK	LQALQKQVET	RSLAAETTEE	EEEEEEVPWT	QHEFELAQWA
FRKWKSHQFT	SLRDLLWGNA	VYLKEANAIS	VELKKKVQFQ	FVLLTDTLYS
PLPPELLPTE	MEKTHEDRPF	PRTVVAVEVQ	DLKNGATHYW	SLEKLKQRLD
LMREMYDRAG	EMASSAQDES	ETTVTGSDPF	YDRFHWFKLV	GSSPIFHGCV
NERLADRTPS	PTFSTADSDI	TELADEQQDE	MEDFDDEAFV	DDAGSDAGTE
EGSDLFSDGH	DPFYDRSPWF	ILVGRAFVYL	SNLLYPVPLI	HRVAIVSEKG
EVRGFLRVAV	QAIAADEEAP	DYGSGIRQSG	TAKISFDNEY	FNQSDFSSVA
MTRSGLSLEE	LRIVEGQGQS	SEVITPPEEI	SRINDLDLKS	STLLDGKMVM
EGFSEEIGNH	LKLGSAFTFR	VTVLQASGIL	PEYADIFCQF	NFLHRHDEAF
STEPLKNNGR	GSPLAFYHVQ	NIAVEITESF	VDYIKTKPIV	FEVFGHYQQH
PLHLQGQELN	SPPQPCRRFF	PPPMPLSKPV	PATKLNTMSK	TSLGQSMSKY
DLLVWFEISE	LEPTGEYIPA	VVDHTAGLPC	QGTFLLHQGI	QRRITVTIIH
EKGSELHWKD	VRELVVGRIR	NKPEVDEAAV	DAILSLNIIS	AKYLKSSHNS
SRTFYRFEAV	WDSSLHNSLL	LNRVTPYGEK	IYMTLSAYLE	LDHCIQPAVI
TKDVCMVFYS	RDAKISPPRS	LRSLFGSGYS	KSPDSNRVTG	IYELSLCKMS
DTGSPGMQRR	RRKILDTSVA	YVRGEENLAG	WRPRGDSLIL	EHQWELEKLE
LLHEVEKTRH	FLLLRERLGD	SIPKSLSDSL	SPSLSSGTLS	TSTSISSQIS
TTTFESAITP	SESSGYDSGD	IESLVDREKE	LATKCLQLLT	HTFNREFSQV
HGSVSDCKLS	DISPIGRDPS	ESSFSSATLT	PSSTCPSLVD	SRSNSLDQKT
PEANSRASSP	CPEFEQFQIV	PAVETPYLAR	AGKNEFLNLV	PDIEEIRPSS
VVSKKGYLHF	KEPLYSNWAK	HFVVVRRPYV	FIYNSDKDPV	ERGIINLSTA
QVEYSEDQQA	MVKTPNTFAV	CTKHRGVLLQ	ALNDKDMNDW	LYAFNPLLAG
TIRSKLSRRC	PSQSKY

Klinički značaj uredi

Ovaj protein povezuje se sa Charcot–Marie–Toothovom bolešću, tip 2A1.^[7]

Interakcije uredi

Pokazano je da je KIF1B u interakciji sa GIPC1.^[9]

Reference uredi

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000054523 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000063077 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zhao C, Takita J, Tanaka Y, Setou M, Nakagawa T, Takeda S, Yang HW, Terada S, Nakata T, Takei Y, Saito M, Tsuji S, Hayashi Y, Hirokawa N (Jun 2001). "Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta". Cell. 105 (5): 587–97. doi:10.1016/S0092-8674(01)00363-4. PMID 11389829. S2CID 17303998.
^ Nagai M, Ichimiya S, Ozaki T, Seki N, Mihara M, Furuta S, Ohira M, Tomioka N, Nomura N, Sakiyama S, Kubo O, Takakura K, Hori T, Nakagawara A (maj 2000). "Identification of the full-length KIAA0591 gene encoding a novel kinesin-related protein which is mapped to the neuroblastoma suppressor gene locus at 1p36.2". Int J Oncol. 16 (5): 907–16. doi:10.3892/ijo.16.5.907. PMID 10762626.
^ ^a ^b "Entrez Gene: KIF1B kinesin family member 1B".
^ "UniProt, O60333" (jezik: eng.). Pristupljeno 29. 11. 2021.CS1 održavanje: nepoznati jezik (link)
^ Bunn, R C; Jensen M A; Reed B C (Apr 1999). "Protein Interactions with the Glucose Transporter Binding Protein GLUT1CBP That Provide a Link between GLUT1 and the Cytoskeleton". Mol. Biol. Cell. 10 (4): 819–32. doi:10.1091/mbc.10.4.819. ISSN 1059-1524. PMC 25204. PMID 10198040.

Dopunska literatura uredi

Nangaku M, Sato-Yoshitake R, Okada Y, et al. (1995). "KIF1B, a novel microtubule plus end-directed monomeric motor protein for transport of mitochondria". Cell. 79 (7): 1209–20. doi:10.1016/0092-8674(94)90012-4. PMID 7528108. S2CID 38430180.
Gong TL, Burmeister M, Lomax MI (1997). "The novel gene D4Mil1e maps to mouse chromosome 4 and human chromosome 1p36". Mamm. Genome. 7 (10): 790–1. doi:10.1007/s003359900237. PMID 8854876. S2CID 40174732.
Saito M, Hayashi Y, Suzuki T, et al. (1998). "Linkage mapping of the gene for Charcot-Marie-Tooth disease type 2 to chromosome 1p (CMT2A) and the clinical features of CMT2A". Neurology. 49 (6): 1630–5. doi:10.1212/wnl.49.6.1630. PMID 9409358. S2CID 32002103.
Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
Bunn RC, Jensen MA, Reed BC (1999). "Protein Interactions with the Glucose Transporter Binding Protein GLUT1CBP That Provide a Link between GLUT1 and the Cytoskeleton". Mol. Biol. Cell. 10 (4): 819–32. doi:10.1091/mbc.10.4.819. PMC 25204. PMID 10198040.
Conforti L, Buckmaster EA, Tarlton A, et al. (1999). "The major brain isoform of kif1b lacks the putative mitochondria-binding domain". Mamm. Genome. 10 (6): 617–22. doi:10.1007/s003359901056. PMID 10341097. S2CID 24223913.
Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
Yang HW, Chen YZ, Takita J, et al. (2001). "Genomic structure and mutational analysis of the human KIF1B gene which is homozygously deleted in neuroblastoma at chromosome 1p36.2". Oncogene. 20 (36): 5075–83. doi:10.1038/sj.onc.1204456. PMID 11526494.
Mok H, Shin H, Kim S, et al. (2002). "Association of the kinesin superfamily motor protein KIF1Balpha with postsynaptic density-95 (PSD-95), synapse-associated protein-97, and synaptic scaffolding molecule PSD-95/discs large/zona occludens-1 proteins". J. Neurosci. 22 (13): 5253–8. doi:10.1523/JNEUROSCI.22-13-05253.2002. PMC 6758229. PMID 12097473.
Nakamura N, Miyake Y, Matsushita M, et al. (2003). "KIF1Bbeta2, capable of interacting with CHP, is localized to synaptic vesicles". J. Biochem. 132 (3): 483–91. doi:10.1093/oxfordjournals.jbchem.a003246. PMID 12204119.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Huang YS, Carson JH, Barbarese E, Richter JD (2003). "Facilitation of dendritic mRNA transport by CPEB". Genes Dev. 17 (5): 638–53. doi:10.1101/gad.1053003. PMC 196011. PMID 12629046.
Chen YY, Takita J, Chen YZ, et al. (2004). "Genomic structure and mutational analysis of the human KIF1Balpha gene located at 1p36.2 in neuroblastoma". Int. J. Oncol. 23 (3): 737–44. doi:10.3892/ijo.23.3.737. PMID 12888911.
Rodriguez M, Yu X, Chen J, Songyang Z (2004). "Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains". J. Biol. Chem. 278 (52): 52914–8. doi:10.1074/jbc.C300407200. PMID 14578343.
Nagaraja GM, Kandpal RP (2004). "Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins". Biochem. Biophys. Res. Commun. 313 (3): 654–65. doi:10.1016/j.bbrc.2003.12.001. PMID 14697242.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.

Vanjski linkovi uredi

GeneReviews/NCBI/NIH/UW entry on Charcot-Marie-Tooth Neuropathy Type 2

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000054523 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000063077 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11389829-5] Zhao C, Takita J, Tanaka Y, Setou M, Nakagawa T, Takeda S, Yang HW, Terada S, Nakata T, Takei Y, Saito M, Tsuji S, Hayashi Y, Hirokawa N (Jun 2001). "Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta". Cell. 105 (5): 587–97. doi:10.1016/S0092-8674(01)00363-4. PMID 11389829. S2CID 17303998.

[pmid10762626-6] Nagai M, Ichimiya S, Ozaki T, Seki N, Mihara M, Furuta S, Ohira M, Tomioka N, Nomura N, Sakiyama S, Kubo O, Takakura K, Hori T, Nakagawara A (maj 2000). "Identification of the full-length KIAA0591 gene encoding a novel kinesin-related protein which is mapped to the neuroblastoma suppressor gene locus at 1p36.2". Int J Oncol. 16 (5): 907–16. doi:10.3892/ijo.16.5.907. PMID 10762626.

[entrez-7] "Entrez Gene: KIF1B kinesin family member 1B".

[UniProt-8] "UniProt, O60333" (jezik: eng.). Pristupljeno 29. 11. 2021.CS1 održavanje: nepoznati jezik (link)

[pmid10198040-9] Bunn, R C; Jensen M A; Reed B C (Apr 1999). "Protein Interactions with the Glucose Transporter Binding Protein GLUT1CBP That Provide a Link between GLUT1 and the Cytoskeleton". Mol. Biol. Cell. 10 (4): 819–32. doi:10.1091/mbc.10.4.819. ISSN 1059-1524. PMC 25204. PMID 10198040.

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