Glipikan 5

Glipikan 5
Identifikatori
Aliasi	GPC5
Vanjski ID-jevi	OMIM: 602446 MGI: 1194894 HomoloGene: 3285 GeneCards: GPC5
Lokacija gena (čovjek)
Hrom.	Hromosom 13 (čovjek)
Kraj	92,873,682 bp
Lokacija gena (miš)
Hrom.	Hromosom 14 (miš)
Kraj	116,762,591 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• heparan sulfate proteoglycan binding;
Ćelijska komponenta	• integral component of plasma membrane; • extracellular region; • membrana; • anchored component of membrane; • Golgi lumen; • ćelijska membrana; • lysosomal lumen; • Vanćelijsko; • anchored component of plasma membrane; • integral component of membrane; • collagen-containing extracellular matrix; • cell surface;
Biološki proces	• glycosaminoglycan biosynthetic process; • retinoid metabolic process; • glycosaminoglycan catabolic process; • regulation of signal transduction; • Ćelijska migracija; • positive regulation of canonical Wnt signaling pathway; • regulation of protein localization to membrane;
	Izvori:Amigo / QuickGO
Ortolozi
	2262
	103978
	ENSG00000179399
	ENSMUSG00000022112
	P78333
	Q8CAL5
	NM_004466
	NM_175500
	NP_004457
	NP_780709
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Glipikan-5 je protein koji je kod ljudi kodiran genom GPC5, koji se nalazio na hromosomu 13, sekvenca 13q31.3, raspon baznih parova 91,398.621 – 92,873,682 bp.^[5]^[6]

Heparan sulfatni proteoglikani na površini ćelije, sastoje se od proteinskog jezgra povezanog s membranom, supstituirane s promjenjivim brojem lanaca heparan-sulfata. Članovi glipikano povezane proteoglikanske porodice membrana (GRIPS) sadrže jezgreni protein usidren u citoplazmatsku membranu, preko veze glikozil-fosfatidilinositola. Ovi proteini mogu imati ulogu u kontroli diobe ćelija i regulaciji rasta.^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 572 aminokiseline, a molekulska težina 63.707 Da.^[7]

10	20	30	40	50
MDAQTWPVGF	RCLLLLALVG	SARSEGVQTC	EEVRKLFQWR	LLGAVRGLPD
SPRAGPDLQV	CISKKPTCCT	RKMEERYQIA	ARQDMQQFLQ	TSSSTLKFLI
SRNAAAFQET	LETLIKQAEN	YTSILFCSTY	RNMALEAAAS	VQEFFTDVGL
YLFGADVNPE	EFVNRFFDSL	FPLVYNHLIN	PGVTDSSLEY	SECIRMARRD
VSPFGNIPQR	VMGQMGRSLL	PSRTFLQALN	LGIEVINTTD	YLHFSKECSR
ALLKMQYCPH	CQGLALTKPC	MGYCLNVMRG	CLAHMAELNP	HWHAYIRSLE
ELSDAMHGTY	DIGHVLLNFH	LLVNDAVLQA	HLNGQKLLEQ	VNRICGRPVR
TPTQSPRCSF	DQSKEKHGMK	TTTRNSEETL	ANRRKEFINS	LRLYRSFYGG
LADQLCANEL	AAADGLPCWN	GEDIVKSYTQ	RVVGNGIKAQ	SGNPEVKVKG
IDPVINQIID	KLKHVVQLLQ	GRSPKPDKWE	LLQLGSGGGM	VEQVSGDCDD
EDGCGGSGSG	EVKRTLKITD	WMPDDMNFSD	VKQIHQTDTG	STLDTTGAGC
AVATESMTFT	LISVVMLLPG	IW

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

Također pogledajte

Glipikan

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000179399 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022112 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Veugelers M, Vermeesch J, Reekmans G, Steinfeld R, Marynen P, David G (Jun 1997). "Characterization of glypican-5 and chromosomal localization of human GPC5, a new member of the glypican gene family". Genomics. 40 (1): 24–30. doi:10.1006/geno.1996.4518. PMID 9070915.
^ ^a ^b "Entrez Gene: GPC5 glypican 5".
^ "UniProt, P78333". Pristupljeno 11. 9. 2017.

Dopunska literatura

De Cat B, David G (2001). "Developmental roles of the glypicans". Semin. Cell Dev. Biol. 12 (2): 117–25. doi:10.1006/scdb.2000.0240. PMID 11292377.
Watanabe K, Yamada H, Yamaguchi Y (1995). "K-glypican: a novel GPI-anchored heparan sulfate proteoglycan that is highly expressed in developing brain and kidney". J. Cell Biol. 130 (5): 1207–18. doi:10.1083/jcb.130.5.1207. PMC 2120559. PMID 7657705.
Saunders S, Paine-Saunders S, Lander AD (1997). "Expression of the cell surface proteoglycan glypican-5 is developmentally regulated in kidney, limb, and brain" (PDF). Dev. Biol. 190 (1): 78–93. doi:10.1006/dbio.1997.8690. PMID 9331333.
Veugelers M, De Cat B, Delande N, et al. (2002). "A 4-Mb BAC/PAC contig and complete genomic structure of the GPC5/GPC6 gene cluster on chromosome 13q32". Matrix Biol. 20 (5–6): 375–85. doi:10.1016/S0945-053X(01)00143-3. PMID 11566272.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Yu W, Inoue J, Imoto I, et al. (2004). "GPC5 is a possible target for the 13q31-q32 amplification detected in lymphoma cell lines". J. Hum. Genet. 48 (6): 331–5. doi:10.1007/s10038-003-0026-2. PMID 12721791.
Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000179399 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022112 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9070915-5] Veugelers M, Vermeesch J, Reekmans G, Steinfeld R, Marynen P, David G (Jun 1997). "Characterization of glypican-5 and chromosomal localization of human GPC5, a new member of the glypican gene family". Genomics. 40 (1): 24–30. doi:10.1006/geno.1996.4518. PMID 9070915.

[entrez-6] "Entrez Gene: GPC5 glypican 5".

[UniProt-7] "UniProt, P78333". Pristupljeno 11. 9. 2017.

[5]

[6]

[1]

[2]

[3]

[4]

[7]