GPA33

GPA33
Identifikatori
Aliasi	GPA33
Vanjski ID-jevi	OMIM: 602171 MGI: 1891703 HomoloGene: 4245 GeneCards: GPA33
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	167,166,479 bp
Lokacija gena (miš)
Hrom.	Hromosom 1 (miš)
Kraj	165,994,079 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ortolozi
	10223
	59290
	ENSG00000143167
	ENSMUSG00000000544
	Q99795
	Q9JKA5
	NM_005814
	NM_021610; NM_001360925; NM_001360926
	NP_005805
	NP_067623; NP_001347854; NP_001347855
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Ćelijskopovršinski antigen A33 jest protein koji je kod ljudi kodiran genom GPA33 sa hromosoma 1.^[5]^[6]^[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 319 aminokiselina, a molekulska težina 35.632 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MVGKMWPVLW	TLCAVRVTVD	AISVETPQDV	LRASQGKSVT	LPCTYHTSTS
SREGLIQWDK	LLLTHTERVV	IWPFSNKNYI	HGELYKNRVS	ISNNAEQSDA
SITIDQLTMA	DNGTYECSVS	LMSDLEGNTK	SRVRLLVLVP	PSKPECGIEG
ETIIGNNIQL	TCQSKEGSPT	PQYSWKRYNI	LNQEQPLAQP	ASGQPVSLKN
ISTDTSGYYI	CTSSNEEGTQ	FCNITVAVRS	PSMNVALYVG	IAVGVVAALI
IIGIIIYCCC	CRGKDDNTED	KEDARPNREA	YEEPPEQLRE	LSREREEEDD
YRQEEQRSTG	RESPDHLDQ

Funkcija

Glikoprotein kodiran ovim genom je antigen ćelijske površine koji je eksprimiran u više od 95% ljudskih karcinom debelog crijeva. Otvoreni okvir čitanja kodira polipeptid od 319 aminokiselina koji ima navodnu sekretornu signalnu sekvencu i tri potencijalna mjesta glikozilacije. Predviđeni zreli protein ima vanćelijsku regiju od 213 aminokiselina, jedan transmembranski domen i unutarćelijski rep od 62 aminokiseline. Sekvenca vanćelijskog regiona sadrži dva domena karakteristična za CD2 podgrupu natporodice imunoglobulina (Ig).^[7]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143167 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000000544 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Heath JK, White SJ, Johnstone CN, Catimel B, Simpson RJ, Moritz RL, Tu GF, Ji H, Whitehead RH, Groenen LC, Scott AM, Ritter G, Cohen L, Welt S, Old LJ, Nice EC, Burgess AW (Mar 1997). "The human A33 antigen is a transmembrane glycoprotein and a novel member of the immunoglobulin superfamily". Proc Natl Acad Sci U S A. 94 (2): 469–74. Bibcode:1997PNAS...94..469H. doi:10.1073/pnas.94.2.469. PMC 19536. PMID 9012807.
^ Ritter G, Cohen LS, Nice EC, Catimel B, Burgess AW, Moritz RL, Ji H, Heath JK, White SJ, Welt S, Old LJ, Simpson RJ (Sep 1997). "Characterization of posttranslational modifications of human A33 antigen, a novel palmitoylated surface glycoprotein of human gastrointestinal epithelium". Biochem Biophys Res Commun. 236 (3): 682–6. doi:10.1006/bbrc.1997.6966. PMID 9245713.
^ ^a ^b "Entrez Gene: GPA33 glycoprotein A33 (transmembrane)".
^ "UniProt, Q99795" (jezik: en.). Pristupljeno 11. 12. 2021.CS1 održavanje: nepoznati jezik (link)

Dopunska literatura

Hwang SH, Sohn YH, Oh HB, et al. (2007). "Human leukocyte antigen alleles and haplotypes associated with chronicity of hepatitis B virus infection in Koreans". Arch. Pathol. Lab. Med. 131 (1): 117–21. doi:10.5858/2007-131-117-HLAAAH. PMID 17227111.^{[mrtav link]}
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Mao Z, Song S, Zhu Y, et al. (2003). "Transcriptional regulation of A33 antigen expression by gut-enriched Krüppel-like factor". Oncogene. 22 (28): 4434–43. doi:10.1038/sj.onc.1206508. PMID 12853980. S2CID 38283384.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Johnstone CN, White SJ, Tebbutt NC, et al. (2002). "Analysis of the regulation of the A33 antigen gene reveals intestine-specific mechanisms of gene expression". J. Biol. Chem. 277 (37): 34531–9. doi:10.1074/jbc.M204865200. PMID 12114523. S2CID 36386508.
Moritz RL, Ritter G, Catimel B, et al. (1998). "Micro-sequencing strategies for the human A33 antigen, a novel surface glycoprotein of human gastrointestinal epithelium". Journal of Chromatography A. 798 (1–2): 91–101. doi:10.1016/S0021-9673(97)01031-5. PMID 9542130.

Vanjski linkovi

GPA33 lokacija ljudskog genoma UCSC Genome Browser.

GPA33 detalji ljudskog genoma u UCSC Genome Browser.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143167 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000000544 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9012807-5] Heath JK, White SJ, Johnstone CN, Catimel B, Simpson RJ, Moritz RL, Tu GF, Ji H, Whitehead RH, Groenen LC, Scott AM, Ritter G, Cohen L, Welt S, Old LJ, Nice EC, Burgess AW (Mar 1997). "The human A33 antigen is a transmembrane glycoprotein and a novel member of the immunoglobulin superfamily". Proc Natl Acad Sci U S A. 94 (2): 469–74. Bibcode:1997PNAS...94..469H. doi:10.1073/pnas.94.2.469. PMC 19536. PMID 9012807.

[pmid9245713-6] Ritter G, Cohen LS, Nice EC, Catimel B, Burgess AW, Moritz RL, Ji H, Heath JK, White SJ, Welt S, Old LJ, Simpson RJ (Sep 1997). "Characterization of posttranslational modifications of human A33 antigen, a novel palmitoylated surface glycoprotein of human gastrointestinal epithelium". Biochem Biophys Res Commun. 236 (3): 682–6. doi:10.1006/bbrc.1997.6966. PMID 9245713.

[entrez-7] "Entrez Gene: GPA33 glycoprotein A33 (transmembrane)".

[UniProt-8] "UniProt, Q99795" (jezik: en.). Pristupljeno 11. 12. 2021.CS1 održavanje: nepoznati jezik (link)

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