GBP1

Interferonski-inducirani gvanilat-vezujući protein 1 jest protein koji je kod ljudi kodiran genom GBP1 sa hromosoma 1. Pripada dinaminskoj natporodici velikih GTPaza.

GBP1
Dostupne strukture PDB Pretraga Human UniProta: PDBe RCSB Spisak PDB ID kodova 1DG3, 1F5N, 2B8W, 2B92, 2BC9, 2D4H
Identifikatori
Aliasi	GBP1
Vanjski ID-jevi	OMIM: 600411 HomoloGene: 133759 GeneCards: GBP1
Lokacija gena (čovjek) Hrom. Hromosom 1 (čovjek) Bend 1p22.2 Početak 89,051,882 bp Kraj 89,065,360 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • nucleotide binding • Hsp90 protein binding • spectrin binding • GO:0001948, GO:0016582 vezivanje za proteine • vezivanje identičnih proteina • vezivanje enzima • actin binding • hydrolase activity • GO:0019974 cytokine binding • GO:0006184 GTPase activity • GTP binding • GDP binding • protein homodimerization activity Ćelijska komponenta • citosol • membrana • Golđijeva membrana • ćelijska membrana • extracellular region • citoplazma • Golđijev aparat • vesicle membrane • actin cytoskeleton • GO:0016023 citoplazmatska vezikula Biološki proces • immune system process • interferon-gamma-mediated signaling pathway • negative regulation of T cell receptor signaling pathway • negative regulation of protein localization to plasma membrane • defense response to virus • regulation of calcium-mediated signaling • negative regulation of ERK1 and ERK2 cascade • negative regulation of substrate adhesion-dependent cell spreading • regulation of protein localization to plasma membrane • protein homooligomerization • cellular response to interferon-gamma • cellular response to interleukin-1 • cellular response to tumor necrosis factor • protein localization to vacuole Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	2633	n/a
Ensembl	ENSG00000117228	n/a
UniProt	P32455	n/a
RefSeq (mRNK)	NM_002053	n/a
RefSeq (bjelančevina)	NP_002044	n/a
Lokacija (UCSC)	Chr 1: 89.05 – 89.07 Mb	n/a
PubMed pretraga		n/a
Wikipodaci
Pogledaj/uredi – čovjek

Amiokiselininska sekvenca

Dužina polipeptidnog lanca je 592 aminokiseline, a molekulska težina 67.931 Da..

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MASEIHMTGP		MCLIENTNGR		LMANPEALKI		LSAITQPMVV		VAIVGLYRTG
KSYLMNKLAG		KKKGFSLGST		VQSHTKGIWM		WCVPHPKKPG		HILVLLDTEG
LGDVEKGDNQ		NDSWIFALAV		LLSSTFVYNS		IGTINQQAMD		QLYYVTELTH
RIRSKSSPDE		NENEVEDSAD		FVSFFPDFVW		TLRDFSLDLE		ADGQPLTPDE
YLTYSLKLKK		GTSQKDETFN		LPRLCIRKFF		PKKKCFVFDR		PVHRRKLAQL
EKLQDEELDP		EFVQQVADFC		SYIFSNSKTK		TLSGGIQVNG		PRLESLVLTY
VNAISSGDLP		CMENAVLALA		QIENSAAVQK		AIAHYEQQMG		QKVQLPTETL
QELLDLHRDS		EREAIEVFIR		SSFKDVDHLF		QKELAAQLEK		KRDDFCKQNQ
EASSDRCSAL		LQVIFSPLEE		EVKAGIYSKP		GGYRLFVQKL		QDLKKKYYEE
PRKGIQAEEI		LQTYLKSKES		MTDAILQTDQ		TLTEKEKEIE		VERVKAESAQ
ASAKMLQEMQ		RKNEQMMEQK		ERSYQEHLKQ		LTEKMENDRV		QLLKEQERTL
ALKLQEQEQL		LKEGFQKESR		IMKNEIQDLQ		TKMRRRKACT		IS

Funkcija

Gvanilatna ekspresija vezivnog proteina indukovana je interferonom. Proteini koji se vezuju za gvanilat karakteriše njihova sposobnost da specifično vežu nukleotide guanina (GMP, GDP i GTP) i razlikuju se od GTP-vezujućih proteina po prisustvu dva motiva vezivanja, a ne tri.

Dopunska literatura

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• Cheng YS, Patterson CE, Staeheli P (1991). "Interferon-induced guanylate-binding proteins lack an N(T)KXD consensus motif and bind GMP in addition to GDP and GTP". Mol. Cell. Biol. 11 (9): 4717–25. doi:10.1128/MCB.11.9.4717. PMC 361367. PMID 1715024.
• Nantais DE, Schwemmle M, Stickney JT, et al. (1996). "Prenylation of an interferon-gamma-induced GTP-binding protein: the human guanylate binding protein, huGBP1". J. Leukoc. Biol. 60 (3): 423–31. doi:10.1002/jlb.60.3.423. PMID 8830800. S2CID 33727864.
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• Prakash B, Praefcke GJ, Renault L, et al. (2000). "Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins". Nature. 403 (6769): 567–71. Bibcode:2000Natur.403..567P. doi:10.1038/35000617. PMID 10676968. S2CID 4431592.
• Kumar S, Li Q, Dua A, et al. (2001). "Messenger ribonucleic acid encoding interferon-inducible guanylate binding protein 1 is induced in human endometrium within the putative window of implantation". J. Clin. Endocrinol. Metab. 86 (6): 2420–7. doi:10.1210/jc.86.6.2420. PMID 11397834.
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• Naschberger E, Werner T, Vicente AB, et al. (2004). "Nuclear factor-kappaB motif and interferon-alpha-stimulated response element co-operate in the activation of guanylate-binding protein-1 expression by inflammatory cytokines in endothelial cells". Biochem. J. 379 (Pt 2): 409–20. doi:10.1042/BJ20031873. PMC 1224089. PMID 14741045.
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