G6B
Protein G6b jest protein koji je kod ljudi kodiran genom G6B ili C6orf25.[5][6][7]
Aminokiselinska sekvenca uredi
Dužina polipeptidnog lanca je 241 aminokiselina, а molekulska težina 26.163 Da.[8]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MAVFLQLLPL | LLSRAQGNPG | ASLDGRPGDR | VNLSCGGVSH | PIRWVWAPSF | ||||
| PACKGLSKGR | RPILWASSSG | TPTVPPLQPF | VGRLRSLDSG | IRRLELLLSA | ||||
| GDSGTFFCKG | RHEDESRTVL | HVLGDRTYCK | APGPTHGSVY | PQLLIPLLGA | ||||
| GLVLGLGALG | LVWWLHRRLP | PQPIRPLPRF | APLVKTEPQR | PVKEEEPKIP | ||||
| GDLDQEPSLL | YADLDHLALS | RPRRLSTADP | ADASTIYAVV | V |
Funkcija uredi
Ovaj gen je član natporodice imunoglobulina (Ig) i nalazi se u regiji klase III glavnog kompleksa histokompatibilnosti (MHC). Protein kodiran ovim genom je glikozilirani receptor ćelijske površine vezan za plazmamembranu, ali su topljive izoforme kodirane nekim varijantama transkripta u endoplazmatskom retikulumu i Golgijevom aparatu prije izlučivanja. Za ovaj gen pronađeno je više varijanti transkripta koje kodiraju različite izoforme.[7]
Reference uredi
- ^ a b c ENSG00000224393, ENSG00000204420, ENSG00000237459, ENSG00000230060, ENSG00000228090, ENSG00000231003 GRCh38: Ensembl release 89: ENSG00000206396, ENSG00000224393, ENSG00000204420, ENSG00000237459, ENSG00000230060, ENSG00000228090, ENSG00000231003 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000073414 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Ribas G, Neville M, Wixon JL, Cheng J, Campbell RD (Jul 1999). "Genes encoding three new members of the leukocyte antigen 6 superfamily and a novel member of Ig superfamily, together with genes encoding the regulatory nuclear chloride ion channel protein (hRNCC) and an N omega-N omega-dimethylarginine dimethylaminohydrolase homologue, are found in a 30-kb segment of the MHC class III region". J Immunol. 163 (1): 278–87. PMID 10384126.
- ^ de Vet EC, Aguado B, Campbell RD (Nov 2001). "G6b, a novel immunoglobulin superfamily member encoded in the human major histocompatibility complex, interacts with SHP-1 and SHP-2". J Biol Chem. 276 (45): 42070–6. doi:10.1074/jbc.M103214200. PMID 11544253.
- ^ a b "Entrez Gene: C6orf25 chromosome 6 open reading frame 25".
- ^ "UniProt, O95866" (jezik: engleski). Zanemaren tekst "2021-10-02" (pomoć)
Dopunska literatura uredi
- Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
- Xie T, Rowen L, Aguado B, et al. (2004). "Analysis of the Gene-Dense Major Histocompatibility Complex Class III Region and Its Comparison to Mouse". Genome Res. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMC 403804. PMID 14656967.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- de Vet EC, Newland SA, Lyons PA, et al. (2005). "The cell surface receptor G6b, a member of the immunoglobulin superfamily, binds heparin". FEBS Lett. 579 (11): 2355–8. doi:10.1016/j.febslet.2005.03.032. PMID 15848171. S2CID 24445026.
- Newland SA, Macaulay IC, Floto AR, et al. (2007). "The novel inhibitory receptor G6B is expressed on the surface of platelets and attenuates platelet function in vitro". Blood. 109 (11): 4806–9. doi:10.1182/blood-2006-09-047449. PMID 17311996.
- Li J, Cadeiras M, Prinz von Bayern M, et al. (2007). "G6b-B cell surface inhibitory receptor expression is highly restricted to CD4+ T-cells and induced by interleukin-4-activated STAT6 pathway". Hum. Immunol. 68 (8): 708–14. doi:10.1016/j.humimm.2007.04.008. PMID 17678728.