FUBP1
Daleki uzvodnovezujući element proteina 1 jest protein koji je kod ljudi kodiran genom FUBP1 sa hromosoma 1.[5][6]
Amiokiselininska sekvenca
urediDužina polipeptidnog lanca je 644 aminokiseline, a molekulska težina 67.560 Da.[7]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MADYSTVPPP | SSGSAGGGGG | GGGGGGVNDA | FKDALQRARQ | IAAKIGGDAG | ||||
| TSLNSNDYGY | GGQKRPLEDG | DQPDAKKVAP | QNDSFGTQLP | PMHQQQSRSV | ||||
| MTEEYKVPDG | MVGFIIGRGG | EQISRIQQES | GCKIQIAPDS | GGLPERSCML | ||||
| TGTPESVQSA | KRLLDQIVEK | GRPAPGFHHG | DGPGNAVQEI | MIPASKAGLV | ||||
| IGKGGETIKQ | LQERAGVKMV | MIQDGPQNTG | ADKPLRITGD | PYKVQQAKEM | ||||
| VLELIRDQGG | FREVRNEYGS | RIGGNEGIDV | PIPRFAVGIV | IGRNGEMIKK | ||||
| IQNDAGVRIQ | FKPDDGTTPE | RIAQITGPPD | RCQHAAEIIT | DLLRSVQAGN | ||||
| PGGPGPGGRG | RGRGQGNWNM | GPPGGLQEFN | FIVPTGKTGL | IIGKGGETIK | ||||
| SISQQSGARI | ELQRNPPPNA | DPNMKLFTIR | GTPQQIDYAR | QLIEEKIGGP | ||||
| VNPLGPPVPH | GPHGVPGPHG | PPGPPGPGTP | MGPYNPAPYN | PGPPGPAPHG | ||||
| PPAPYAPQGW | GNAYPHWQQQ | APPDPAKAGT | DPNSAAWAAY | YAHYYQQQAQ | ||||
| PPPAAPAGAP | TTTQTNGQGD | QQNPAPAGQV | DYTKAWEEYY | KKMGQAVPAP | ||||
| TGAPPGGQPD | YSAAWAEYYR | QQAAYYAQTS | PQGMPQHPPA | PQGQ |
Funkcija
urediOvaj gen kodira protein koji se vezuje za ssDNK, a koji aktivira daleko uzvodni element (FUSE) c-myc i stimulira ekspresiju c-myc u nediferenciranim ćelijama. Regulacija FUSE-a pomoću FUBP-a se događa jednolančanim vezivanjem FUBP-a za nekodirajući lanac. Pokazalo se da ovaj protein funkcionira kao ATP-ovisna DNK helikaza.[6]
Interakcije
urediPokazalo se da protein 1 koji vezuje elemente daleko uzvodno reaguje sa MAPK14[8] i SMN1.[9]
Reference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000162613 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028034 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Duncan R, Bazar L, Michelotti G, Tomonaga T, Krutzsch H, Avigan M, Levens D (april 1994). "A sequence-specific, single-strand binding protein activates the far upstream element of c-myc and defines a new DNA-binding motif". Genes Dev. 8 (4): 465–80. doi:10.1101/gad.8.4.465. PMID 8125259.
- ^ a b "Entrez Gene: FUBP1 far upstream element (FUSE) binding protein 1".
- ^ "UniProt, Q96AE4" (jezik: eng.). Pristupljeno 27. 11. 2021.CS1 održavanje: nepoznati jezik (link)
- ^ Kim, Min Jung; Park Bum-Joon; Kang Young-Sun; Kim Hyoung June; Park Jae-Hyun; Kang Jung Woo; Lee Sang Won; Han Jung Min; Lee Han-Woong; Kim Sunghoon (juli 2003). "Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation". Nat. Genet. United States. 34 (3): 330–6. doi:10.1038/ng1182. ISSN 1061-4036. PMID 12819782. S2CID 41006480.
- ^ Williams, B Y; Hamilton S L; Sarkar H K (mart 2000). "The survival motor neuron protein interacts with the transactivator FUSE binding protein from human fetal brain". FEBS Lett. NETHERLANDS. 470 (2): 207–10. doi:10.1016/S0014-5793(00)01320-X. ISSN 0014-5793. PMID 10734235. S2CID 28330997.
Dopunska literatura
uredi- Williams BY, Hamilton SL, Sarkar HK (2000). "The survival motor neuron protein interacts with the transactivator FUSE binding protein from human fetal brain". FEBS Lett. 470 (2): 207–10. doi:10.1016/S0014-5793(00)01320-X. PMID 10734235. S2CID 28330997.
- Liu J, He L, Collins I, et al. (2000). "The FBP interacting repressor targets TFIIH to inhibit activated transcription". Mol. Cell. 5 (2): 331–41. doi:10.1016/S1097-2765(00)80428-1. PMID 10882074.
- Markovtsov V, Nikolic JM, Goldman JA, et al. (2000). "Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein". Mol. Cell. Biol. 20 (20): 7463–79. doi:10.1128/MCB.20.20.7463-7479.2000. PMC 86300. PMID 11003644.
- He L, Weber A, Levens D (2000). "Nuclear targeting determinants of the far upstream element binding protein, a c-myc transcription factor". Nucleic Acids Res. 28 (22): 4558–65. doi:10.1093/nar/28.22.4558. PMC 113884. PMID 11071946.
- Vindigni A, Ochem A, Triolo G, Falaschi A (2001). "Identification of human DNA helicase V with the far upstream element-binding protein". Nucleic Acids Res. 29 (5): 1061–7. doi:10.1093/nar/29.5.1061. PMC 29729. PMID 11222755.
- Liu J, Akoulitchev S, Weber A, et al. (2001). "Defective interplay of activators and repressors with TFIH in xeroderma pigmentosum". Cell. 104 (3): 353–63. doi:10.1016/S0092-8674(01)00223-9. PMID 11239393.
- Braddock DT, Louis JM, Baber JL, et al. (2002). "Structure and dynamics of KH domains from FBP bound to single-stranded DNA". Nature. 415 (6875): 1051–6. Bibcode:2002Natur.415.1051B. doi:10.1038/4151051a. PMID 11875576. S2CID 4401103.
- Rappsilber J, Ryder U, Lamond AI, Mann M (2002). "Large-scale proteomic analysis of the human spliceosome". Genome Res. 12 (8): 1231–45. doi:10.1101/gr.473902. PMC 186633. PMID 12176931.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Kim MJ, Park BJ, Kang YS, et al. (2003). "Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation". Nat. Genet. 34 (3): 330–6. doi:10.1038/ng1182. PMID 12819782. S2CID 41006480.
- Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Kouzine F, Liu J, Sanford S, et al. (2004). "The dynamic response of upstream DNA to transcription-generated torsional stress". Nat. Struct. Mol. Biol. 11 (11): 1092–100. doi:10.1038/nsmb848. PMID 15502847. S2CID 28956216.
- Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
- Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
- Fautsch MP, Vrabel AM, Johnson DH (2006). "The identification of myocilin-associated proteins in the human trabecular meshwork". Exp. Eye Res. 82 (6): 1046–52. doi:10.1016/j.exer.2005.09.016. PMID 16289162.
- Liu J, Kouzine F, Nie Z, et al. (2006). "The FUSE/FBP/FIR/TFIIH system is a molecular machine programming a pulse of c-myc expression". EMBO J. 25 (10): 2119–30. doi:10.1038/sj.emboj.7601101. PMC 1462968. PMID 16628215.
- Ko HS, Kim SW, Sriram SR, et al. (2006). "Identification of far upstream element-binding protein-1 as an authentic Parkin substrate". J. Biol. Chem. 281 (24): 16193–6. doi:10.1074/jbc.C600041200. PMID 16672220.