FBXL7

FBXL7
Identifikatori
Aliasi	FBXL7
Vanjski ID-jevi	OMIM: 605656 MGI: 3052506 HomoloGene: 69121 GeneCards: FBXL7
Lokacija gena (čovjek)
Hrom.	Hromosom 5 (čovjek)
Kraj	15,939,795 bp
Lokacija gena (miš)
Hrom.	Hromosom 15 (miš)
Kraj	26,895,666 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0050372 aktivnost sa transferazom ubikvitina;
Ćelijska komponenta	• citoplazma; • kompleks ubikvitin-ligaze; • centar organizacije mikrotubula; • centrosom; • SCF ubiquitin ligase complex; • citoskelet; • citosol;
Biološki proces	• Ćelijska dioba; • ćelijski ciklus; • Ćelijska proliferacija; • G2/M transition of mitotic cell cycle; • protein ubiquitination; • ubiquitin-dependent protein catabolic process; • protein polyubiquitination; • SCF complex assembly; • negative regulation of G2/M transition of mitotic cell cycle; • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; • GO:0007067 Mitoza; • Posttranslacione modifikacije;
	Izvori:Amigo / QuickGO
Ortolozi
	23194
	448987
	ENSG00000183580
	ENSMUSG00000043556
	Q9UJT9
	Q5BJ29
	NM_001278317; NM_012304
	NM_176959
	NP_001265246; NP_036436
	NP_795933
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Protein 3 sa domenom kinaze FAST (FASTKD3) jest protein koji je kod ljudi kodiran genom FASTKD3 sa hromosoma 5.^[5]^[6] Ovaj protein je dio Fas-aktiviranog domens serin/]]treonin]]-kinaze (FASTKD) koja sadrži porodicu proteina, koja je poznata po regulaciji energetske ravnoteže mitohondrija pod stresom.^[7]^[8]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 662 aminokiseline, а molekulska težina Da. 75.689^[9]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MALITLRKNL	YRLSDFQMHR	ALAALKNKPL	NHVHKVVKER	LCPWLCSRQP
EPFGVKFHHA	HCKKFHSKNG	NDLHPLGGPV	FSQVSDCDRL	EQNVKNEESQ
MFYRRLSNLT	SSEEVLSFIS	TMETLPDTMA	AGALQRICEV	EKKDGDQGLP
KEILENSIFQ	ALCFQFEKEP	SQLSNTSLVT	ALQALILLHV	DPQSSLLLNL
VAECQNRLRK	GGMEVRNLCI	LGESLITLHS	SGCVTLELII	NQLQGEKLET
FTPEDIVALY	RILQACTEKV	DEHQTFLNKI	NNFSLSIVSN	LSPKLISQML
TALVVLDQSQ	AFPLIIKLGK	YVVRHVPHFT	NEELRRVLEA	FIYFGHHDTF
FTKALEHRVA	AVCLTLDPEV	VCRVMEYCSR	ELILSKPILN	AVAETFVCQT
EKFSPRQISA	LMEPFGKLNY	LPPNASALFR	KLENVLFTHF	NYFPPKSLLK
LLHSCSLNEC	HPVNFLAKIF	KPLFLQRLQG	KESHLDTLSR	AQLTQLFLAS
VLECPFYKGP	KLLPKYQVKS	FLTPCCSLET	PVDSQLYRYV	KIGLTNLLGA
RLYFAPKVLT	PYCYTIDVEI	KLDEEGFVLP	STANEDIHKR	IALCIDGPKR
FCSNSKHLLG	KEAIKQRHLQ	LLGYQVVQIP	YHEIGMLKSR	RELVEYLQRK
LFSQNTVHWL	QE

Struktura

FASTKD3 ima strukturne karakteristike porodice FASTKD, uključujući N-terminalni mitohondrijski ciljni domen i tri C-terminalna domena: dva slična FAST-kinazi (FAST_1 i FAST_2) i RNK-vezujući domen (RAP).^[7]^[8] Mitohondrijski ciljni domen usmjerava FASTKD3 na import u mitohondrije. Iako su funkcije C-terminalnih domena nepoznate, RAP vjerovatno veže RNK tokom trans-splajsinga.^[7]

Funkcija

Kao član porodice FASTKD, FASTKD3 nalazi se u mitohondrijama, kako bi modulirao njihovu energetsku ravnotežu, posebno u uvjetima stresa. Iako je sveprisutno izražen u svim tkivima, FASTKD3 se obilnije pojavljuje u skeletnim i srčanim mišićima, te drugim tkivima obogaćenim mitohondrijama. Predloženo je da FASTKD3 regulira proizvodnju energije, služeći kao protein skele koji okuplja preradu RNK/translaciju i respiratorne komponente.^[7]

Klinički značaj

Do septembra 2015., nije nađeno da je FASTKD3 povezan sa bilo kojom bolešću.

Interakcije

Pokazalo se da FASTKD3 ulazi u interakcije sa:

FASTKD2;
Proteinima okskidacijskog puta masnih kiselina (ACADVL, ECHS1, HADHA, HADHB, ACAA2);
Proteinima kataboliznog puta aminokiselina (MCCC1, MCCC2, GLUD1, HIBADH, CPS1);
Proteinima biosinteze aminokiselina (PYCR1, PYCR2, ALDH18A1, SHMT2, GLS);
Proteimima TCA-ciklusa (IDH3A, IDH2, SUCLG2, DLST);
Proteinima lanca ćelijskog disanja (NDUFS1, SDHA, ATP5A1, ETFA, ETFB);
Peoteinima prerade mitohondrijske RNK (LRPPRC, DHX30, PNPT1); and
Proteinima mitohhondrijske translacije (TUFM, GFM1, IARS2, MRPS22, TARS2, MRPS2, PTCD1, MTO1, MRPS31).^[7]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000183580 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000043556 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ UniProt: Q9NYY8
^ "Entrez Gene: FAST kinase domains 2".
^ ^a ^b ^c ^d ^e Simarro M, Gimenez-Cassina A, Kedersha N, Lazaro JB, Adelmant GO, Marto JA, Rhee K, Tisdale S, Danial N, Benarafa C, Orduña A, Anderson P (Oct 2010). "Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration". Biochemical and Biophysical Research Communications. 401 (3): 440–6. doi:10.1016/j.bbrc.2010.09.075. PMC 2963690. PMID 20869947.
^ ^a ^b Yeung KT, Das S, Zhang J, Lomniczi A, Ojeda SR, Xu CF, Neubert TA, Samuels HH (Jun 2011). "A novel transcription complex that selectively modulates apoptosis of breast cancer cells through regulation of FASTKD2". Molecular and Cellular Biology. 31 (11): 2287–98. doi:10.1128/MCB.01381-10. PMC 3133243. PMID 21444724.
^ "UniProt, Q14CZ7" (jezik: engleski). Pristupljeno 15. 10. 2021.

Dopunska kiteratura

Lai Y, Song M, Hakala K, Weintraub ST, Shiio Y (Nov 2011). "Proteomic dissection of the von Hippel-Lindau (VHL) interactome". Journal of Proteome Research. 10 (11): 5175–82. doi:10.1021/pr200642c. PMC 3208728. PMID 21942715.
Simarro M, Gimenez-Cassina A, Kedersha N, Lazaro JB, Adelmant GO, Marto JA, Rhee K, Tisdale S, Danial N, Benarafa C, Orduña A, Anderson P (Oct 2010). "Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration". Biochemical and Biophysical Research Communications. 401 (3): 440–6. doi:10.1016/j.bbrc.2010.09.075. PMC 2963690. PMID 20869947.

Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000183580 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000043556 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[uniprot-5] UniProt: Q9NYY8

[entrez-6] "Entrez Gene: FAST kinase domains 2".

[pmid20869947-7] Simarro M, Gimenez-Cassina A, Kedersha N, Lazaro JB, Adelmant GO, Marto JA, Rhee K, Tisdale S, Danial N, Benarafa C, Orduña A, Anderson P (Oct 2010). "Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration". Biochemical and Biophysical Research Communications. 401 (3): 440–6. doi:10.1016/j.bbrc.2010.09.075. PMC 2963690. PMID 20869947.

[pmid21444724-8] Yeung KT, Das S, Zhang J, Lomniczi A, Ojeda SR, Xu CF, Neubert TA, Samuels HH (Jun 2011). "A novel transcription complex that selectively modulates apoptosis of breast cancer cells through regulation of FASTKD2". Molecular and Cellular Biology. 31 (11): 2287–98. doi:10.1128/MCB.01381-10. PMC 3133243. PMID 21444724.

[UniProt-9] "UniProt, Q14CZ7" (jezik: engleski). Pristupljeno 15. 10. 2021.

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