FAM19A1

FAM19A1
Identifikatori
Aliasi	TAFA1
Vanjski ID-jevi	OMIM: 617495 MGI: 2443695 HomoloGene: 45655 GeneCards: TAFA1
Lokacija gena (čovjek)
Hrom.	Hromosom 3 (čovjek)
Kraj	68,545,621 bp
Lokacija gena (miš)
Hrom.	Hromosom 6 (miš)
Kraj	96,634,159 bp
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • receptor ligand activity;
Ćelijska komponenta	• Endoplazmatski retikulum; • extracellular region; • Vanćelijsko;
Biološki proces	• regulation of signaling receptor activity; • neuroblast differentiation; • regulation of neuroblast proliferation; • GO:0072468 Transdukcija signala;
	Izvori:Amigo / QuickGO
Ortolozi
	407738
	320265
	ENSG00000183662
	ENSMUSG00000059187
	Q7Z5A9
	Q7TPG8
	NM_213609; NM_001252216
	NM_182808
	NP_001239145; NP_998774
	NP_877960
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Protein FAM19A1 jest protein koji je kod ljudi kodiran genom FAM19A1 sa hromosoma 3.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 133 aminokiselina, а molekulska težina 14.901 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MAMVSAMSWV	LYLWISACAM	LLCHGSLQHT	FQQHHLHRPE	GGTCEVIAAH
RCCNKNRIEE	RSQTVKCSCL	PGKVAGTTRN	RPSCVDASIV	IGKWWCEMEP
CLEGEECKTL	PDNSGWMCAT	GNKIKTTRIH	PRT

Funkcija

Ovaj gen je član porodice TAFA koja se sastoji od pet visoko homolognih gena koji kodiraju male izlučene proteine. Ovi proteini sadrže konzervirane cisteinske ostatke na fiksnim pozicijama i udaljeni su srodnici sa MIP-1 alfa, članom porodice CC-hemokina. TAFA proteini su pretežno eksprimirani u specifičnim regijama mozga, a pretpostavlja se da funkcioniraju kao hemokini specifični za mozak ili neurokini koji djeluju kao regulatori imunskih i nervnih ćelija.^[6]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000183662 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000059187 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tom Tang Y, Emtage P, Funk WD, Hu T, Arterburn M, Park EE, Rupp F (Mar 2004). "TAFA: a novel secreted family with conserved cysteine residues and restricted expression in the brain". Genomics. 83 (4): 727–34. doi:10.1016/j.ygeno.2003.10.006. PMID 15028294.
^ ^a ^b "Entrez Gene: FAM19A1 family with sequence similarity 19 (chemokine (C-C motif)-like), member A1".
^ "UniProt, Q7Z5A9" (jezik: engleski). Pristupljeno 3. 11. 2021.

Dopunska literatura

Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000183662 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000059187 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15028294-5] Tom Tang Y, Emtage P, Funk WD, Hu T, Arterburn M, Park EE, Rupp F (Mar 2004). "TAFA: a novel secreted family with conserved cysteine residues and restricted expression in the brain". Genomics. 83 (4): 727–34. doi:10.1016/j.ygeno.2003.10.006. PMID 15028294.

[entrez-6] "Entrez Gene: FAM19A1 family with sequence similarity 19 (chemokine (C-C motif)-like), member A1".

[UniProt-7] "UniProt, Q7Z5A9" (jezik: engleski). Pristupljeno 3. 11. 2021.

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