ETV5
Ets varijanta transkripcijskog faktora 5 (ETV5) (također pod nazivom ERM transkripcijski faktor) je transkripcijski faktor koji je kod ljudi kodiran gen om ETV5 sa hromosoma 3.[5] Generteaju ga Sertolijeve ćelije, koje se nalaze u sjemenicima i imaju ključnu ulogu u spermatogenezi. Njegov ortolog je povezan i sa gojaznošću i bipolarnim poremećajem.[6]
| ETS varijanta gena 5 (ETS-srodna molekula) | |||||||
|---|---|---|---|---|---|---|---|
 | |||||||
| Identifikatori | |||||||
| Simbol | ETV5 | ||||||
| Alt. simboli | ERM | ||||||
| NCBI gen | 2119 | ||||||
| HGNC | 3494 | ||||||
| OMIM | 601600 | ||||||
| RefSeq | NM_004454 | ||||||
| UniProt | P41161 | ||||||
| Ostali podaci | |||||||
| Lokus | Hrom. 3 q28 | ||||||
| |||||||
Aminokiselinska sekvenca
urediDužina polipeptidnog lanca je 510 aminokiselina, а molekulska težina 57.838 Da.[7]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MDGFYDQQVP | FMVPGKSRSE | ECRGRPVIDR | KRKFLDTDLA | HDSEELFQDL | ||||
| SQLQEAWLAE | AQVPDDEQFV | PDFQSDNLVL | HAPPPTKIKR | ELHSPSSELS | ||||
| SCSHEQALGA | NYGEKCLYNY | CAYDRKPPSG | FKPLTPPTTP | LSPTHQNPLF | ||||
| PPPQATLPTS | GHAPAAGPVQ | GVGPAPAPHS | LPEPGPQQQT | FAVPRPPHQP | ||||
| LQMPKMMPEN | QYPSEQRFQR | QLSEPCHPFP | PQPGVPGDNR | PSYHRQMSEP | ||||
| IVPAAPPPPQ | GFKQEYHDPL | YEHGVPGMPG | PPAHGFQSPM | GIKQEPRDYC | ||||
| VDSEVPNCQS | SYMRGGYFSS | SHEGFSYEKD | PRLYFDDTCV | VPERLEGKVK | ||||
| QEPTMYREGP | PYQRRGSLQL | WQFLVTLLDD | PANAHFIAWT | GRGMEFKLIE | ||||
| PEEVARRWGI | QKNRPAMNYD | KLSRSLRYYY | EKGIMQKVAG | ERYVYKFVCD | ||||
| PDALFSMAFP | DNQRPFLKAE | SECHLSEEDT | LPLTHFEDSP | AYLLDMDRCS | ||||
| SLPYAEGFAY |
Reference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000244405 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000013089 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Ets variant 5".
- ^ Williams MJ, Klockars A, Eriksson A, Voisin S, Dnyansagar R, Wiemerslage L, Kasagiannis A, Akram M, Kheder S, Ambrosi V, Hallqvist E, Fredriksson R, Schiöth HB (juni 2016). "The Drosophila ETV5 Homologue Ets96B: Molecular Link between Obesity and Bipolar Disorder". PLOS Genetics. 12 (6): e1006104. doi:10.1371/journal.pgen.1006104. PMC 4900636. PMID 27280443.
- ^ "UniProt, P41161" (jezik: engleski). Pristupljeno 7. 11. 2021.
Dopunska literatura
uredi- T'sas F, Brenner C, Mauen S, Putmans P, Monté D, Van Lint C, Moser M, Baert JL, de Launoit Y (januar 2005). "Expression of the Ets transcription factor Erm is regulated through a conventional PKC signaling pathway in the Molt4 lymphoblastic cell line". FEBS Letters. 579 (1): 66–70. doi:10.1016/j.febslet.2004.11.052. PMID 15620692. S2CID 25112599.
- Brandys MK, van Elburg AA, Loos RJ, Bauer F, Hendriks J, van der Schouw YT, Adan RA (mart 2010). "Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa?". American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics. 153B (2): 695–9. doi:10.1002/ajmg.b.31026. PMID 19746409. S2CID 45793585.
- Colas E, Muinelo-Romay L, Alonso-Alconada L, Llaurado M, Monge M, Barbazan J, Gonzalez M, Schoumacher M, Pedrola N, Ertekin T, Devis L, Ruiz A, Castellvi J, Doll A, Gil-Moreno A, Vazquez-Levin M, Lapyckyj L, Lopez-Lopez R, Robine S, Friederich E, Castro M, Reventos J, Vignjevic D, Abal M (novembar 2012). "ETV5 cooperates with LPP as a sensor of extracellular signals and promotes EMT in endometrial carcinomas". Oncogene. 31 (45): 4778–88. doi:10.1038/onc.2011.632. PMID 22266854.
- Wang X, Yeh S, Wu G, Hsu CL, Wang L, Chiang T, Yang Y, Guo Y, Chang C (novembar 2001). "Identification and characterization of a novel androgen receptor coregulator ARA267-alpha in prostate cancer cells". The Journal of Biological Chemistry. 276 (44): 40417–23. doi:10.1074/jbc.M104765200. PMID 11509567.
- Korz C, Pscherer A, Benner A, Mertens D, Schaffner C, Leupolt E, Döhner H, Stilgenbauer S, Lichter P (juni 2002). "Evidence for distinct pathomechanisms in B-cell chronic lymphocytic leukemia and mantle cell lymphoma by quantitative expression analysis of cell cycle and apoptosis-associated genes". Blood. 99 (12): 4554–61. doi:10.1182/blood.V99.12.4554. PMID 12036888.
- Chotteau-Lelièvre A, Révillion F, Lhotellier V, Hornez L, Desbiens X, Cabaret V, de Launoit Y, Peyrat JP (novembar 2004). "Prognostic value of ERM gene expression in human primary breast cancers". Clinical Cancer Research. 10 (21): 7297–303. doi:10.1158/1078-0432.CCR-04-0593. PMID 15534105.
- Planagumà J, Liljeström M, Alameda F, Bützow R, Virtanen I, Reventós J, Hukkanen M (januar 2011). "Matrix metalloproteinase-2 and matrix metalloproteinase-9 codistribute with transcription factors RUNX1/AML1 and ETV5/ERM at the invasive front of endometrial and ovarian carcinoma". Human Pathology. 42 (1): 57–67. doi:10.1016/j.humpath.2010.01.025. PMID 20970160.
- Monge M, Colas E, Doll A, Gil-Moreno A, Castellvi J, Diaz B, Gonzalez M, Lopez-Lopez R, Xercavins J, Carreras R, Alameda F, Canals F, Gabrielli F, Reventos J, Abal M (august 2009). "Proteomic approach to ETV5 during endometrial carcinoma invasion reveals a link to oxidative stress". Carcinogenesis. 30 (8): 1288–97. doi:10.1093/carcin/bgp119. PMID 19443906.
- Ng MC, Tam CH, So WY, Ho JS, Chan AW, Lee HM, Wang Y, Lam VK, Chan JC, Ma RC (maj 2010). "Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese". The Journal of Clinical Endocrinology and Metabolism. 95 (5): 2418–25. doi:10.1210/jc.2009-2077. PMID 20215397.
Vanjski linkovi
uredi- ERM protein, human na US National Library of Medicine Medical Subject Headings (MeSH)
- ETV5 protein, human na US National Library of Medicine Medical Subject Headings (MeSH)