ERAP2

ERAP2
Dostupne strukture
PDB	Pretraga Human UniProta: PDBe RCSB
Spisak PDB ID kodova
	3SE6, 4E36, 4JBS, 5CU5, 5AB2, 5AB0
Identifikatori
Aliasi	ERAP2
Vanjski ID-jevi	OMIM: 609497 HomoloGene: 75183 GeneCards: ERAP2
Lokacija gena (čovjek)
Hrom.	Hromosom 5 (čovjek)
Kraj	96,919,703 bp
Ontologija gena
Molekularna funkcija	• aminopeptidase activity; • metallopeptidase activity; • GO:0070122 peptidase activity; • hydrolase activity; • vezivanje iona cinka; • vezivanje iona metala; • peptide binding; • metalloaminopeptidase activity; • endopeptidase activity;
Ćelijska komponenta	• integral component of membrane; • endoplasmic reticulum lumen; • endoplasmic reticulum membrane; • membrana; • Endoplazmatski retikulum; • ćelijska membrana; • citoplazma;
Biološki proces	• immune system process; • adaptive immune response; • Proteoliza; • regulation of blood pressure; • antigen processing and presentation of peptide antigen via MHC class I; • peptide catabolic process; • antigen processing and presentation of endogenous peptide antigen via MHC class I; • GO:0072468 Transdukcija signala; • cell-cell signaling;
	Izvori:Amigo / QuickGO
Ortolozi
	64167
	n/a
	ENSG00000164308
	n/a
	Q6P179
	n/a
	NM_001130140; NM_022350; NM_001329229; NM_001329233
	n/a
	NP_001123612; NP_001316158; NP_001316162; NP_071745
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek

Endoplazmatskoretikulumska aminopeptidaza 2 jest protein/enzim koji je kod ljudi kodiran genom ERAP2.^[3]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 960 aminokiselina, а molekulska težina 110.462 Da.^[4]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MFHSSAMVNS	HRKPMFNIHR	GFYCLTAILP	QICICSQFSV	PSSYHFTEDP
GAFPVATNGE	RFPWQELRLP	SVVIPLHYDL	FVHPNLTSLD	FVASEKIEVL
VSNATQFIIL	HSKDLEITNA	TLQSEEDSRY	MKPGKELKVL	SYPAHEQIAL
LVPEKLTPHL	KYYVAMDFQA	KLGDGFEGFY	KSTYRTLGGE	TRILAVTDFE
PTQARMAFPC	FDEPLFKANF	SIKIRRESRH	IALSNMPKVK	TIELEGGLLE
DHFETTVKMS	TYLVAYIVCD	FHSLSGFTSS	GVKVSIYASP	DKRNQTHYAL
QASLKLLDFY	EKYFDIYYPL	SKLDLIAIPD	FAPGAMENWG	LITYRETSLL
FDPKTSSASD	KLWVTRVIAH	ELAHQWFGNL	VTMEWWNDIW	LKEGFAKYME
LIAVNATYPE	LQFDDYFLNV	CFEVITKDSL	NSSRPISKPA	ETPTQIQEMF
DEVSYNKGAC	ILNMLKDFLG	EEKFQKGIIQ	YLKKFSYRNA	KNDDLWSSLS
NSCLESDFTS	GGVCHSDPKM	TSNMLAFLGE	NAEVKEMMTT	WTLQKGIPLL
VVKQDGCSLR	LQQERFLQGV	FQEDPEWRAL	QERYLWHIPL	TYSTSSSNVI
HRHILKSKTD	TLDLPEKTSW	VKFNVDSNGY	YIVHYEGHGW	DQLITQLNQN
HTLLRPKDRV	GLIHDVFQLV	GAGRLTLDKA	LDMTYYLQHE	TSSPALLEGL
SYLESFYHMM	DRRNISDISE	NLKRYLLQYF	KPVIDRQSWS	DKGSVWDRML
RSALLKLACD	LNHAPCIQKA	AELFSQWMES	SGKLNIPTDV	LKIVYSVGAQ
TTAGWNYLLE	QYELSMSSAE	QNKILYALST	SKHQEKLLKL	IELGMEGKVI
KTQNLAALLH	AIARRPKGQQ	LAWDFVRENW	THLLKKFDLG	SYDIRMIISG
TTAHFSSKDK	LQEVKLFFES	LEAQGSHLDI	FQTVLETITK	NIKWLEKNLP
TLRTWLMVNT

Funkcija

Aminopeptidaze hidroliziraju N-terminalne aminokiseline proteina ili peptidnog supstrata. Molekule glavnog kompleksa histokompatibilnosti (MHC) klase I oslanjaju se na aminopeptidaze, kao što su ERAP1 i LRAP, za podrezivanje prekursora antigenih peptida u endoplazmatskom retikulumu (ER), nakon cijepanja u citoplazmatskih proteina tripeptidil-peptidazom II (TPP2).^[5]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164308 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Endoplasmic reticulum amino peptidase 2".
^ "UniProt, Q6P179" (jezik: engleski). Pristupljeno 14. 10. 2021.
^ Tanioka T, Hattori A, Masuda S, Nomura Y, Nakayama H, Mizutani S, Tsujimoto M (Aug 2003). "Human leukocyte-derived arginine aminopeptidase. The third member of the oxytocinase subfamily of aminopeptidases". The Journal of Biological Chemistry. 278 (34): 32275–83. doi:10.1074/jbc.M305076200. PMID 12799365.

Dopunska literatura

Xu XR, Huang J, Xu ZG, Qian BZ, Zhu ZD, Yan Q, Cai T, Zhang X, Xiao HS, Qu J, Liu F, Huang QH, Cheng ZH, Li NG, Du JJ, Hu W, Shen KT, Lu G, Fu G, Zhong M, Xu SH, Gu WY, Huang W, Zhao XT, Hu GX, Gu JR, Chen Z, Han ZG (Dec 2001). "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver". Proceedings of the National Academy of Sciences of the United States of America. 98 (26): 15089–15094. doi:10.1073/pnas.241522398. PMC 64988. PMID 11752456.
Hill LD, Hilliard DD, York TP, Srinivas S, Kusanovic JP, Gomez R, Elovitz MA, Romero R, Strauss JF (2011). "Fetal ERAP2 variation is associated with preeclampsia in African Americans in a case-control study". BMC Medical Genetics. 12: 64. doi:10.1186/1471-2350-12-64. PMC 3103419. PMID 21569342.
Ascher DB, Polekhina G, Parker MW (Apr 2012). "Crystallization and preliminary X-ray diffraction analysis of human endoplasmic reticulum aminopeptidase 2". Acta Crystallographica Section F. 68 (Pt 4): 468–471. doi:10.1107/S1744309112006963. PMC 3325822. PMID 22505422.
Kamphausen E, Kellert C, Abbas T, Akkad N, Tenzer S, Pawelec G, Schild H, van Endert P, Seliger B (Aug 2010). "Distinct molecular mechanisms leading to deficient expression of ER-resident aminopeptidases in melanoma". Cancer Immunology, Immunotherapy. 59 (8): 1273–84. doi:10.1007/s00262-010-0856-7. PMID 20419298. S2CID 24302488.
Stratikos E, Stern LJ (Oct 2013). "Antigenic peptide trimming by ER aminopeptidases--insights from structural studies". Molecular Immunology. 55 (3–4): 212–219. doi:10.1016/j.molimm.2013.03.002. PMC 3657621. PMID 23545452.
Bjornsson HT, Albert TJ, Ladd-Acosta CM, Green RD, Rongione MA, Middle CM, Irizarry RA, Broman KW, Feinberg AP (maj 2008). "SNP-specific array-based allele-specific expression analysis". Genome Research. 18 (5): 771–779. doi:10.1101/gr.073254.107. PMC 2336807. PMID 18369178.
Mason CC, Hanson RL, Ossowski V, Bian L, Baier LJ, Krakoff J, Bogardus C (2011). "Bimodal distribution of RNA expression levels in human skeletal muscle tissue". BMC Genomics. 12: 98. doi:10.1186/1471-2164-12-98. PMC 3044673. PMID 21299892.
Haroon N, Tsui FW, Chiu B, Tsui HW, Inman RD (Sep 2010). "Serum cytokine receptors in ankylosing spondylitis: relationship to inflammatory markers and endoplasmic reticulum aminopeptidase polymorphisms". The Journal of Rheumatology. 37 (9): 1907–10. doi:10.3899/jrheum.100019. PMID 20595269. S2CID 27707315.
Qu HQ, Marchand L, Fréchette R, Bacot F, Lu Y, Polychronakos C (Mar 2007). "No association of type 1 diabetes with a functional polymorphism of the LRAP gene". Molecular Immunology. 44 (8): 2135–8. doi:10.1016/j.molimm.2006.10.015. PMID 17129607.

Vanjski linkovi

Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164308 - Ensembl, maj 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: Endoplasmic reticulum amino peptidase 2".

[UniProt-4] "UniProt, Q6P179" (jezik: engleski). Pristupljeno 14. 10. 2021.

[5] Tanioka T, Hattori A, Masuda S, Nomura Y, Nakayama H, Mizutani S, Tsujimoto M (Aug 2003). "Human leukocyte-derived arginine aminopeptidase. The third member of the oxytocinase subfamily of aminopeptidases". The Journal of Biological Chemistry. 278 (34): 32275–83. doi:10.1074/jbc.M305076200. PMID 12799365.

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