Endomucin jest protein koji je kod ljudi kodiran genom EMCN sa hromosoma 4.[5][6][7] Endomucin je marker za endolelne[8] i hematopoetske matične ćelije.[9]

EMCN
Identifikatori
AliasiEMCN
Vanjski ID-jeviOMIM: 608350 MGI: 1891716 HomoloGene: 9438 GeneCards: EMCN
Lokacija gena (čovjek)
Hromosom 4 (čovjek)
Hrom.Hromosom 4 (čovjek)[1]
Hromosom 4 (čovjek)
Genomska lokacija za EMCN
Genomska lokacija za EMCN
Bend4q24Početak100,395,341 bp[1]
Kraj100,880,126 bp[1]
Lokacija gena (miš)
Hromosom 3 (miš)
Hrom.Hromosom 3 (miš)[2]
Hromosom 3 (miš)
Genomska lokacija za EMCN
Genomska lokacija za EMCN
Bend3|3 G3Početak137,046,828 bp[2]
Kraj137,137,946 bp[2]
Obrazac RNK ekspresije
Više referentnih podataka o ekspresiji
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_001159694
NM_016242

NM_001163522
NM_016885

RefSeq (bjelančevina)

NP_001153166
NP_057326

NP_001156994
NP_058581

Lokacija (UCSC)Chr 4: 100.4 – 100.88 MbChr 3: 137.05 – 137.14 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

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Dužina polipeptidnog lanca je 261 aminokiselina, а molekulska težina 27.452 Da.[10]

1020304050
MELLQVTILFLLPSICSSNSTGVLEAANNSLVVTTTKPSITTPNTESLQK
NVVTPTTGTTPKGTITNELLKMSLMSTATFLTSKDEGLKATTTDVRKNDS
IISNVTVTSVTLPNAVSTLQSSKPKTETQSSIKTTEIPGSVLQPDASPSK
TGTLTSIPVTIPENTSQSQVIGTEGGKNASTSATSRSYSSIILPVVIALI
VITLSVFVLVGLYRMCWKADPGTPENGNDQPQSDKESVKLLTVKTISHES
GEHSAQGKTKN

Funkcija

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EMCN je mucinoliki sijaloglikoprotein koji ometa sastavljanje fokusnih adhezijskih kompleksa i inhibira interakciju između ćelija i vanćelijskog matriksa.[5][7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164035 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000054690 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Kinoshita M, Nakamura T, Ihara M, Haraguchi T, Hiraoka Y, Tashiro K, Noda M (juni 2001). "Identification of human endomucin-1 and -2 as membrane-bound O-sialoglycoproteins with anti-adhesive activity". FEBS Letters. 499 (1–2): 121–6. doi:10.1016/S0014-5793(01)02520-0. PMID 11418125. S2CID 23615506.
  6. ^ Liu C, Shao ZM, Zhang L, Beatty P, Sartippour M, Lane T, Livingston E, Nguyen M (oktobar 2001). "Human endomucin is an endothelial marker". Biochemical and Biophysical Research Communications. 288 (1): 129–36. doi:10.1006/bbrc.2001.5737. PMID 11594763.
  7. ^ a b "Entrez Gene: EMCN endomucin".
  8. ^ Liu C, et al. (2001). "Human Endomucin Is an Endothelial Marker". Biochemical and Biophysical Research Communications. 288: 129–136. doi:10.1006/bbrc.2001.5737. PMID 11594763.
  9. ^ Matsubara A.; et al. (2005). "Endomucin, a CD34-like sialomucin, marks hematopoietic stem cells throughout development". Journal of Experimental Medicine. 11 (202): 1483–1492. doi:10.1084/jem.20051325. PMC 2213340. PMID 16314436.
  10. ^ "UniProt, Q9ULC0" (jezik: engleski). Pristupljeno 25. 10. 2021.

Dopunska literatura

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