DPYSL5

DPYSL5
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	4B90, 4B91, 4B92
Identifikatori
Aliasi	DPYSL5
Vanjski ID-jevi	OMIM: 608383 MGI: 1929772 HomoloGene: 41347 GeneCards: DPYSL5
Lokacija gena (čovjek)
Hrom.	Hromosom 2 (čovjek)
Kraj	26,950,351 bp
Lokacija gena (miš)
Hrom.	Hromosom 5 (miš)
Kraj	30,956,719 bp
Ontologija gena
Molekularna funkcija	• microtubule binding; • GO:0001948, GO:0016582 vezivanje za proteine; • hydrolase activity; • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; • dihydropyrimidinase activity;
Ćelijska komponenta	• citoplazma; • citosol; • soma; • dendrit;
Biološki proces	• GO:0072468 Transdukcija signala; • nervous system development; • axon guidance; • pyrimidine nucleobase catabolic process;
	Izvori:Amigo / QuickGO
Ortolozi
	56896
	65254
	ENSG00000157851
	ENSMUSG00000029168
	Q9BPU6
	Q9EQF6
	NM_020134; NM_001253723; NM_001253724
	NM_023047; NM_001356948; NM_001356949
	NP_001240652; NP_001240653; NP_064519
	NP_075534; NP_001343877; NP_001343878
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Dihidropirimidinazi-srodni protein 5 jest enzim koji je kod ljudi kodiran genom DPYSL5 sa hromosoma 2.^[5]^[6]^[7]

Amiokiselininska sekvenca

Dužina polipeptidnog lanca je 564 aminokiseline, a molkekulska iežina 61.421 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MLANSASVRI	LIKGGKVVND	DCTHEADVYI	ENGIIQQVGR	ELMIPGGAKV
IDATGKLVIP	GGIDTSTHFH	QTFMNATCVD	DFYHGTKAAL	VGGTTMIIGH
VLPDKETSLV	DAYEKCRGLA	DPKVCCDYAL	HVGITWWAPK	VKAEMETLVR
EKGVNSFQMF	MTYKDLYMLR	DSELYQVLHA	CKDIGAIARV	HAENGELVAE
GAKEALDLGI	TGPEGIEISR	PEELEAEATH	RVITIANRTH	CPIYLVNVSS
ISAGDVIAAA	KMQGKVVLAE	TTTAHATLTG	LHYYHQDWSH	AAAYVTVPPL
RLDTNTSTYL	MSLLANDTLN	IVASDHRPFT	TKQKAMGKED	FTKIPHGVSG
VQDRMSVIWE	RGVVGGKMDE	NRFVAVTSSN	AAKLLNLYPR	KGRIIPGADA
DVVVWDPEAT	KTISASTQVQ	GGDFNLYENM	RCHGVPLVTI	SRGRVVYENG
VFMCAEGTGK	FCPLRSFPDT	VYKKLVQREK	TLKVRGVDRT	PYLGDVAVVV
HPGKKEMGTP	LADTPTRPVT	RHGGMRDLHE	SSFSLSGSQI	DDHVPKRASA
RILAPPGGRS	SGIW

Funkcija

Vjeruje se da članovi porodice CRMP, kao što je DPYSL5, imaju ulogu u konusu rasta tokom razvoja nervnog sistema (prema OMIM^[7])

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000157851 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029168 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Inatome R, Tsujimura T, Hitomi T, Mitsui N, Hermann P, Kuroda S, Yamamura H, Yanagi S (Oct 2000). "Identification of CRAM, a novel unc-33 gene family protein that associates with CRMP3 and protein-tyrosine kinase(s) in the developing rat brain". J Biol Chem. 275 (35): 27291–302. doi:10.1074/jbc.M910126199. PMID 10851247.
^ Horiuchi M, El Far O, Betz H (Nov 2000). "Ulip6, a novel unc-33 and dihydropyrimidinase related protein highly expressed in developing rat brain". FEBS Lett. 480 (2–3): 283–6. doi:10.1016/S0014-5793(00)01952-9. PMID 11034345. S2CID 42248702.
^ ^a ^b "Entrez Gene: DPYSL5 dihydropyrimidinase-like 5".
^ "UniProt, Q9BPU6" (jezik: engleski). Pristupljeno 12. 11. 2021.

Dopunska literatura

Cross SA, Salomao DR, Parisi JE, et al. (2003). "Paraneoplastic autoimmune optic neuritis with retinitis defined by CRMP-5-IgG". Ann. Neurol. 54 (1): 38–50. doi:10.1002/ana.10587. PMID 12838519. S2CID 36493404.
Fukada M, Watakabe I, Yuasa-Kawada J, et al. (2001). "Molecular characterization of CRMP5, a novel member of the collapsin response mediator protein family". J. Biol. Chem. 275 (48): 37957–65. doi:10.1074/jbc.M003277200. PMID 10956643.
Yu Z, Kryzer TJ, Griesmann GE, et al. (2001). "CRMP-5 neuronal autoantibody: marker of lung cancer and thymoma-related autoimmunity". Ann. Neurol. 49 (2): 146–54. doi:10.1002/1531-8249(20010201)49:2<146::AID-ANA34>3.0.CO;2-E. PMID 11220734.
Ricard D, Rogemond V, Charrier E, et al. (2001). "Isolation and expression pattern of human Unc-33-like phosphoprotein 6/collapsin response mediator protein 5 (Ulip6/CRMP5): coexistence with Ulip2/CRMP2 in Sema3a- sensitive oligodendrocytes". J. Neurosci. 21 (18): 7203–14. doi:10.1523/JNEUROSCI.21-18-07203.2001. PMC 6763003. PMID 11549731.
Mitsui N, Inatome R, Takahashi S, et al. (2002). "Involvement of Fes/Fps tyrosine kinase in semaphorin3A signaling". EMBO J. 21 (13): 3274–85. doi:10.1093/emboj/cdf328. PMC 125392. PMID 12093729.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Vanjski linkovi

Q9BPU6

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000157851 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029168 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10851247-5] Inatome R, Tsujimura T, Hitomi T, Mitsui N, Hermann P, Kuroda S, Yamamura H, Yanagi S (Oct 2000). "Identification of CRAM, a novel unc-33 gene family protein that associates with CRMP3 and protein-tyrosine kinase(s) in the developing rat brain". J Biol Chem. 275 (35): 27291–302. doi:10.1074/jbc.M910126199. PMID 10851247.

[pmid11034345-6] Horiuchi M, El Far O, Betz H (Nov 2000). "Ulip6, a novel unc-33 and dihydropyrimidinase related protein highly expressed in developing rat brain". FEBS Lett. 480 (2–3): 283–6. doi:10.1016/S0014-5793(00)01952-9. PMID 11034345. S2CID 42248702.

[entrez-7] "Entrez Gene: DPYSL5 dihydropyrimidinase-like 5".

[UniProt-8] "UniProt, Q9BPU6" (jezik: engleski). Pristupljeno 12. 11. 2021.

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